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Classes

Genetic events that lead to diversification of SH2 families


Class IA

Class IB

Class IC

Class II

Class 0

ABL

SRC

SH2B

STAP

CHN

CRK

CSK

FPS

FRK

GRB7

NCK

PIK3R

PLCG

RIN

SH2D2A

SH2D4

SH2D3

SHC

SHB

PTPN11

SOCS

STAT

JAK

VAV

GRB2

SLP76

TNS

TEC

CBL

SHIP

 

SH2D1

SLAP

SYK

SH3BP2

DAPP1

RASA1

SH2D5

SPT6

Genetic events that lead to diversification of SH2 families.

 (A) Diagram representing the events of domain gain or loss either prior to or after events of gene duplication.   (B) Classification of SH2 families on the basis of genome duplication events and domain loss or gain. Class 0, represented by the RASA1 family, do not undergo gene duplication.   Class IA, represented by the SRC family, undergoes events of complete gene duplication without domain loss or gain. Class 1B, represented by the SLP76 family, diversify by acquiring new domains and undergoing gene duplication.  Class IC, represented by the CBL family, undergoes gene duplication with domain loss.Class II, represented by the SLAP family, undergoes domain loss followed by gene duplication.

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