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SHOW February 2011

posted Mar 6, 2012, 2:12 PM by Steven Munevar   [ updated Dec 27, 2012, 11:05 AM ]

The Development of Humanized Mouse Models for Biomedical Research

Keynote Speaker: Michael A. Brehm, Ph.D.
  • Assistant Professor in the Program of Molecular Medicine, University of Massachusetts Medical School  

January’s SHOW will focus on the development and application of humanized mouse models toward the better understanding of human diseases and therapeutics development.  The presentation will focus on a general overview of humanized mouse models, a brief description of how these invaluable research models are created, and how they are used to study human immunology.


Animal models are important to increasing our understanding of human physiology, specifically in the area of immunology. The production of “humanized mice” that possess partial or complete human physiological systems have been touted as the next generation in model systems that may help overcome current obstacles in biomedical research. Dr. Brehm’s research focuses on the development and application of humanized mouse models to study auto-immunity, allo-immunity, and infectious disease. Currently, Dr. Brehm’s lab applies this technology toward the implantation and engraftment of human cells and tissues into mice.

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