Publicaciones científicas



1.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. HPLC Procedure for Quantitative Determination of Pentylenetetrazol in Serum and Discrete Areas of the Rat Brain. Analytical Biochemistry, 165: 331-336, 1987.

2.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. A Rapid Method for the Determination of Benzilpenicillin in Serum by RP-HPLC. Biomedical Chromatography, 2: 177-179, 1987.

3.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Simultaneous determination of the two components of picrotoxin in serum by reversed phase chromatography and its application to pharmacokinetics studies in rats. J. Pharmac. Biomed Anal., 7: 369-375, 1989.

4.- Sierra-Paredes, G., Soto-Otero, R., Mendez-Alvarez, E., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Experimental spike and wave discharges induced by pentylenetetrazol and tolerance to repeated injections: an electrophysiological and biochemical study. Epilepsy Research, 4: 139-146, 1989.

5.- Sierra-Paredes, G., Soto-Otero, R., Mendez-Alvarez, E., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. A Quantifiable Nonconvulsive Model of Experimental Epilepsy: An Electrophysiological and Biochemical Study. Epilepsia, 29: 667, 1989

6.- Méndez-Alvarez, E., Soto-Otero, R., Sierra-Paredes, G., Aguilar-Veiga, E., Galán-Valiente, J. and Sierra-Marcuño, G. Effects of carbamazepine on the pharmacokinetics and brain levels of phenobarbital after acute and chronic administration in the rat. 2nd International Symposium on Pharmaceutical and Biomedical Analyisis. 1990.

7.-Aguilar-Veiga, E., Sierra-Paredes, G., Galán-Valiente, J., Soto-Otero, R., Méndez-Alvarez, E. y Sierra-Marcuño, G. Possible role of blood-brain barrier in the time course of ethosuximide in the brain. Epilepsia, 31, 5: 602, 1990.

8.- Méndez-Alvarez, E., Soto-Otero, R., Sierra-Paredes, G., Aguilar-Veiga, E., Galán-Valiente, J. and Sierra-Marcuño, G. Reversed-phase Liquid Chromatography Method for the Simultaneous Determination of Several Common Penicillins in Human Serum. Biomedical Chromatography, 5: 78-82, 1991.

9.- Soto-Otero, R., Méndez-Alvarez, E., Sierra-Paredes, G., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Reversed-phase HPLC method for the determination of bemegride in serum and brain tissue: pharmacokinetics and brain distribution of an intraperitoneal subconvulsive dose in rats. J. Pharmac. Biomed. Anal., 9, 2: 177-182, 1991.

10.- Aguilar-Veiga, E., Sierra-Paredes, G., Galán-Valiente, J., Soto-Otero, R., Méndez-Alvarez, E. and Sierra-Marcuño, G. Correlation between ethosuximide brain levels measured by high performance liquid chromatography and its antiepileptic potential. Research Communications in Chemical Pathology and Pharmacology, 71, 3: 351-364, 1991.

11.- Soto-Otero, R., Méndez-Alvarez, E., Galán-Valiente, J., Aguilar-Veiga, E. and Sierra-Marcuño, G. Quantitative analysis of neuroactive amino acids in brain tissue by liquid chromatography using fluorescent pre-column labelling with o-phthalaldehide and N-acetyl-L-cysteine. Biomedical Chromatography, 8:114-118, 1994.

12.- Sierra-Paredes, G. and Sierra-Marcuño, G. Effects of local perfusion of NMDA antagonists on seizures induced by picrotoxin in the rat hippocampus. Epilepsia, 34, supplement 4: 42, 1995.

13.-G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño. Transmitter amino acid levels in seizures induced by picrotoxin microperfusion in the hippocampus of freely moving rats. Epilepsia 37, suppl. 4: 135, 1996.

14.-G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño.Role of transmitter amino acid levels and NMDA receptors on the thresholds of picrotoxin-induced seizures n the hippocampus . Epilepsia 37, suppl 5: 40, 1996

15.- Sierra-Paredes, G. and Sierra-Marcuño, G. Microperfusion of picrotoxin in the hippocampus of chronic freely moving rats through microdialysis probes: A new method of induce partial and secondary generalizad seizures. Journal of Neuroscience Methods. 67: 113-120, 1996.

16.- Sierra-Paredes, G. and Sierra-Marcuño, G. Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats. Neuroscience Letters, 218: 62-66, 1996.

17.-G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño. Effects of Dizocilpine and Diazepam on hippocampal amino acid levels during picrotoxin-induced seizures. Epilepsia, 38, suppl. 6, 1997

18.- G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño. Effects of AMPA and NMDA receptor antagonists on seizure thresholds and extracellular amino acids in seizures induced by intrahippocampal picrotoxin microperfusion. Epilepsia, 38, suppl 7, 1997

19.- Sierra-Paredes, G., Galán-Valiente, J., Vazquez-Illanes, M.D., Aguilar-Veiga, E., Soto-Otero, R., Méndez-Alvarez, E. and Sierra-Marcuño, G. Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic miceodialysis experiments. Neuroscience Letters, 248: 53-56, 1998.

20.- G. Sierra-Paredes, J. Galán-Valiente, M.D. Vazquez-Illanes, E. Aguilar-Veiga, R. Soto-Otero, E. Méndez-Alvarez and G. Sierra-Marcuño. Effects of non-NMDA receptor antagonists on extracellular amino acids concentrations in seizures induced by intrahippocampal picrotoxin microperfusion. Epilepsia, 39, suppl 6: 13, 1998

21.- G. Sierra-Paredes, A. Senra-Vidal and G. Sierra-Marcuño. Effects of glutamate and glycine intrahippocampal microperfusion on the picrotoxin seizure threshold in freely moving rats. Epilepsia, 40, suppl 7: 5, 1999.

22.- Sierra-Paredes, G, Cornes, J.M. and Sierra-Marcuño, G.Calpain inhibitor I reatrds seizure arrest in the hippocampus of freely moving rats. Neuroscience Letters, 263:165-168, 1999.

23.- Sierra-Paredes, G., Galán-Valiente, J.,.Vazquez-Illanes, M. D., Aguilar-Veiga, E. and Sierra-Marcuño, G. . Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.   Neurochemistry International, 37 (4): 377-386, 2000

24.- G. Sierra-Paredes and G. Sierra-Marcuño. In vivo microdialysis: A two way road in the search for new pharmacological targets. 2nd International Symposium on Microdialysis in Drug Research and Development, Stockholm, Sweden, June 14-17, 2000.

25.- G. Sierra-Paredes, M.T. Oreiro-García, J.M. Cornes and G. Sierra-Marcuño. Long-term decrease in picrotoxin seizure threshold induced by in vivo actin depolymerization in the rat hippocampus. Epilepsia, 41, suppl 7: 23, 2000.

26.- Sierra-Paredes, G., Senra-Vidal, A. and Sierra-Marcuño, G. Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. Brain Research, 888: 19-25. 2001.

27.- G. Sierra-Paredes, M.T. Oreiro-García, A. Núñez-Rodríguez and G. Sierra-Marcuño. Induced actin disruption: A new experimental model of epilepsy. Epilepsia, 42 (s7), 2001.

28.- G. Sierra-Paredes, A. Vázquez-López, M.T. Oreiro-García, A. Núñez-Rodríguez and G. Sierra-Marcuño. Seizures induced by perfusing glutamate and glycine in rats pretreated with latrunculin A. Epilepsia, 43, 2002.

29.- Sierra-Paredes, G. and Fuster, JM. Reversible impairment of an auditory-visual association task during cooling of prefrontal cortex. In S. Lomber, R. Galuske (eds), Virtual lesions. Examining cortical function with reversible deactivation. Oxford University Press, Oxford 2002.

30.- G. Sierra-Paredes, M.T. Oreiro-García, A. Vázquez-López, A. Núñez-Rodríguez and G. Sierra-Marcuño. Effect of novel anticonvulsant Bia 2-093 on seizures induced by picrotoxin microdialysis in the rat hippocampus. Epilepsia, 45, 2004.

31.- Araceli Vázquez-López, Germán Sierra-Paredes and Germán Sierra-Marcuño. Role of cAMP-dependent protein kinase on acute picrotoxininduced seizures. Neurochem. Res. 30 (5): 613-618, 2005 .

32.-Araceli Vázquez-López, Germán Sierra-Paredes and Germán Sierra-Marcuño. Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A. Neuroscience Letters 388: 81-85, 2005.

33.- M. Teresa Oreiro-García, M. Dolores Vázquez-Illanes, Germán Sierra-Paredes and Germán Sierra-Marcuño. Analysis of neuroactive amino acids from microdialysate samples by fluorescence detection using a modification of the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate method. Biomed. Chrom. 19, 720-724, 2005.

34.-  G. Sierra-Paredes, M.T. Oreiro-García, A. Vázquez-López, A. Núñez-Rodríguez and G. Sierra-Marcuño. Neurochemistry of Epileptic Seizures: The role of f-Actin, Intercellular  Glutamate, and Glutamate Ionotropic Receptors Location. In: Robert Coleman (Ed), Focus on Neurochemistry Research, Nova Science Publishers, NY, USA, 2005 pp: 157-195.

35. G. Sierra-Paredes, A. Vázquez-López, and G. Sierra-Marcuño. Anticonvulsant effect of PKA and calcineurin inhibitors against seizures induced by picrotoxin microdialysis in the rat hippocampus. Epilepsia 46 (8), 10, 2005.

36. G. Sierra-Marcuño, M.T. Oreiro-García, M.D Vázquez-Illanes, and G. Sierra-Paredes. Effect of novel anticonvulsant BIA 2-093 on latrunculin A-induced seizures and extracellular glutamate concentrations in the rat hippocampus. Epilepsia 46 (8), 302, 2005.

37.-
Sierra-Paredes, G., Oreiro-García, M.T., Núñez-Rodríguez, A. Vázquez-López, A.  and Sierra-Marcuño, G. Seizures induced by in vivo latrunculin A and jasplakinolide microperfusion in the rat hippocampus. Journal of Molecular Neuroscience, 28 (2), 151-160, 2006

38. Vázquez-López A, Sierra-Paredes G, Sierra-Marcuño G. Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.Pharmacol Biochem Behav. 2006 Jul;84(3):511-6.

39. Sierra-Paredes G, Núñez-Rodriguez A, Vázquez-López A, Oreiro-García T, Sierra-Marcuño G. Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats. Epilepsy Res. 2006 Dec;72(2-3):140-6.

40. Oreiro-García MT, Vázquez-Illanes MD, Sierra-Paredes G, Sierra-Marcuño G. Changes in extracellular amino acid concentrations in the rat hippocampus after in vivo actin depolymerization with latrunculin A. Neurochem Int. 2007 Apr;50(5):734-40.

41. G. Sierra-Paredes, M. Oreiro-García, M. Vázquez-Illanes, G. Sierra-Marcuño Effect of eslicarbazepine acetate (BIA 2-093) on latrunculin A-induced seizures and extracellular amino acid concentrations in the rat hippocampus. Epilepsy Research, Volume 77, Issue 1, Pages 36-43, 2007

42. Sierra-Paredes G, Sierra-Marcuño G. Extrasynaptic GABA and glutamate receptors in epilepsy. CNS Neurol Disord Drug Targets. 2007 Aug;6(4):288-300.

43.
Sierra-Paredes G, Sierra-Marcuño G. Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants. CNS Neuroscience & Therapeutics 14 (1) , 36–46, 2008.

44. Sierra-Paredes, G. Recent advances in the neurochemistry of epilepsy. European Neurological Review, 3 (1), 96-98, 2008.

44.
G Sierra-Paredes, A Loureiro, LC Wright, G Sierra-Marcuno, P Soares-da-Silva EFFECTS OF ESLICARBAZEPINE ACETATE ON ACUTE AND CHRONIC LATRUNCULIN A-INDUCED SEIZURES AND EXTRACELLULAR AMINO ACID LEVELS IN THE MOUSE HIPPOCAMPUS EPILEPSIA (Vol. 54, pp. 153-153).

45. Sierra-Paredes, G. "SEARCHING FOR NEW PHARMACOLOGICAL MECHANISMS FOR ANTIEPILEPTIC DRUGS." EPILEPSIA (Vol. 54, pp. 4-5).

46. Antonio Dominguez-Meijide, Begoña Villar-Cheda, Pablo Garrido-Gil, German Sierrra-Paredes, Maria J Guerra, Jose L Labandeira-Garcia Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with l-DOPA Neuropharmacology 76, 156-168

47. Carmen Freire-Cobo, Germán Sierra-Paredes, Manuel Freire, Germán Sierra-Marcuño The Calcineurin Inhibitor Ascomicin Interferes with the Early Stage of the Epileptogenic Process Induced by Latrunculin A Microperfusion in Rat Hippocampus Journal of Neuroimmune Pharmacology Aug 8, 2014