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Provigil is the brand drug which has an active ingredient named Modafinil in it. Physicians prescribe to buy Provigil for treating disorders like Attention Deficit Hyperactivity Disorder (ADHD), narcolepsy, excessive daytime sleepiness, and shift work sleep disorder (SWSD). Provigil is declared under schedule IV class of drugs by the Food and Drug Administration (FDA), Drug Enforcement Administration, and two federal agencies. This category refers to the drugs that have less abuse potential compared to schedule III.

Provigil is a racemic compound and it is a white crystalline powder. This drug is not soluble in water and cyclohexane but is soluble in acetone and methanol. The inactive ingredients in Provigil are pregelatinized starch, lactose monohydrate, povidone, magnesium stearate, microcrystalline cellulose and croscarmellose sodium. Inactive ingredients are commonly known as binding materials like preservatives, dyes, and flavoring agents. It also helps the active ingredient Modafinil to smoothly work throughout the body.

How Provigil works in the central nervous system?

Provigil upgrades the levels of hypothalamic histamine that is present in the brain. During a research on Provigil, it was found that the medication has an ability to obstruct actions that are done by the dopamine transporter. This inhibition of dopamine transporter increases the extracellular activities. Another mechanism found during a research is that Provigil boosts orexin neurons which are present in different parts of the body and orexin neurons is the main reason for promoting wakefulness in the human body. So, by activating these neurons, it will automatically stimulate wakefulness.

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