Rui Chen, Ph.D.
I am currently Research Scientist at Stanford University. I have extensive experience in disease-related research and disease-orientated technology development, and am spearheading personalized health monitoring and preventative medicine with next-generation, high-throughput technologies. I orchestrated the first personalized health monitoring and preventative medicine proof-of-principle study with integrative omics, which was published as the only research paper in the 2012 special issue of Cell. This paper was later selected as “Genome Advance of the Month” by the National Human Genome Research Institute (National Institutes of Health), and also into Cell—Best of 2012. Beyond integrative personal omics research, I have broad expertise in cancer immunology and chemoresistance, and disease-related research such as asthma, Myelodysplastic Syndromes, as well as rare Mendelian diseases. I received my Ph.D. degree from Yale University in 2008 with the John Spangler Nicholas Prize, a prestigious award for most outstanding Ph.D. candidates in Biology,  and completed my postdoctoral training with Dr. Michael Snyder in the Department of Genetics at Stanford University.

Google Scholar Profile (Click Here)

Education:

2002 – 2008   : Doctor of Philosophy (05/2008), Master of Science (05/2005)
Graduate School of Arts and Sciences, Yale University
Department: Molecular, Cellular and Developmental Biology

1999 – 2002   :  Master of Science
School of Life Sciences, Fudan University, P. R. China
Program: Biochemistry and Molecular Biology (Entrance Exam Exempted)

1995 – 1999   :  Bachelor of Science
School of Life Sciences, Fudan University, P. R. China
Program: Biology (09/1995-07/1997); Advanced Science Class (07/1997-07/1999)

Post-Doctoral Training:

2009 – 2014:  Postdoctoral Scholar
Department: Genetics, Stanford University

2008 – 2009:  Postdoctoral Associate
Department: Molecular, Cellular and Developmental Biology, Yale University

Awards and Honors:

DeLill Nasser Award for Professional Development in Genetics from the Genetics Society of America (05/2012).

John Spangler Nicholas Prize for outstanding doctoral student in experimental zoology at the 2008 commencement of Yale University (05/2008).

SGI President’s Presenter Award and Wyeth Pharmaceuticals grant (03/2008).

Chinese Academy of Science Scholarship for Exceptional Graduate Student of Fudan University (2000~2001 academic year).

Exceptional Graduate Student Scholarship of Fudan University (1999~2000 academic year).

Accepted into Master of Science program at Fudan University with exemption from normally mandatory entrance examination due to academic excellence in 1999.

People’s Academic Scholarship of Fudan University (was awarded twice for both semesters) (1997-1998 academic year).

People’s Academic Scholarship of Fudan University (was awarded twice for both semesters) (1996-1997 academic year).

People’s Academic Scholarship of Fudan University (was awarded twice for both semesters) (1995-1996 academic year).

Elected into the Advanced Science Class of Fudan University in 1997.

Publications:

(Please click on the links below to each of my publications)







Enns GM, Shashi V, Bainbridge M, Gambello MJ, Zahir FR, Bast T, Crimian R, Schoch K, Platt J, Cox R, Bernstein JA, Scavina M, Walter RS, Bibb A, Jones M, Hegde M, Graham BH, Need AC, Oviedo A, Schaaf CP, Boyle S, Butte AJ, Chen R, et al. Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway. Genet Med. 2014. doi: 10.1038/gim.2014.22. PMID: 24651605. (Author List Error, Corrigendum Click Here)



           Highlighted as Editors’ Choice. Identified TTC7A as the causal gene for the rare Mendelian disease CID-MIA.

          Article Featured by publisher on the Wiley Life Sciences Blog (WiSci) .


Highlighted. In this study we performed the first integrative Personal Omics Profiling (iPOP) on a generally healthy individual for 14 months, by monitoring various blood components (Peripheral Blood Mononuclear Cells, serum and plasma). During the course we observed extensive, dynamic molecular changes through healthy states and 2 viral infections (Human Rhinovirus and Respiratory Syncytial Virus), as well as an unexpected onset of Type 2 Diabetes. Featured as the only research paper in the March 16th, 2012 special issue of Cell. F1000Prime RECOMMENDED.

Highlighted. In this study we compared 3 different human exome enrichment platforms from Roche Nimblegen, Agilent and Illumina. F1000Prime RECOMMENDED.





          F1000Prime RECOMMENDED. First comparison of Illumina vs Complete Genomics platforms. Served as key experimentalist and coordinator.





          F1000Prime RECOMMENDED.

Kolker E, Özdemir V, Martens L, Hancock W, Dumbill E, Anderson N, Aynacioglu S, Baranova A, Campagna S, Chen R, et al. Towards More Transparent and Reproducible Omics Studies through a Common Metadata Checklist and Data Publications. OMICS / BIG DATA (Accepted, Special Simultaneous Publication in Both Journals).