Inflammation is a well-characterized phenomenon, which involves a cascade of different immune cell types, such as mast cells, neutrophils, macrophages, and T lymphocytes.

Mast cells are cells that play roles in inflammation and immediate allergic reactions, along with other immune cells such as neutrophils, macrophages, and T lymphocytes. A Feature of mast cells is that they are present in mass attached to the connective tissue and do not circulate in the blood stream as other immune cells. However, they do increase at sites of inflammation though migration to the site by the use of receptors. Other roles include involvement in cutaneous and mucosal allergy, anaphylaxis (reaction to allergens, such as nuts), and autoimmune disorders rheumatoid arthritis.

Rudraksha extracts seems to show a stabilizing effect on mast cells hence preventing asthma, a disease of the lungs characterized by shortness of breath.