Robert Huether Ph.D.


As a cancer biologist with a strong computational and experimental biology background, my teams have worked to combine macromolecular structural analysis with population genetics to understand the functional impact of variants in somatic cancers and hereditary diseases. The promise of personalized medicine requires both a detailed understanding of changes on the molecular level leading to a clear therapy for the patient on a reasonable time scale. NGS sequencing has made it possible to identify variants but there still remains a void in classifying the impact these variants have on a patient. My interest is focused on integrating the available rich genomic, structural and functional data to prioritize, interpret, and classify the impact of variants derived from both somatic and germline sequencing projects to generate prognostic, diagnostic, and therapeutic markers for clinical care. My past work has led to the successful adaptation and application of my high throughput structural analysis methods to both somatic cancers and Mendelian diseases in a clinical environment.

Key Capabilities

• Direct teams of scientists, engineers and developers in the development of informatics tools for clinical markets

• Extensive experience in Next Generation Sequencing (NGS) technologies including gene panel and whole exome sequencing for CLIA and CAP certified clinical molecular diagnostic applications.

• Ensure delivery of products of the highest quality according to committed timelines

• Successful track record of leading teams in computational efforts and fostering productive research collaborations

• Strong record of developing and publishing on computational analyses with a focus on human disease

Education and Positions


Director Variant Science

Tempus Labs, Chicago, Il.


Senior Computational Biologist

Tempus Labs, Chicago, Il.


Computational Structural Biologist

Ambry Genetics, Aliso Viejo, Ca


Post-doctoral Training

St. Jude Chidren's Research Hospital, Deptartment of Computational Biology, Memphis, Tn.

Mentor: Jinghui Zhang, PhD.


Ph.D. Structural Biology

State University of New York at Buffalo, Department of Structural Biology (Hauptman-Woodward Institute.), Buffalo, NY

Mentor: William L. Duax, Ph.D.


M.A. Biology

State University of New York at Buffalo, Department of Biology


B.S. Biology

State University of New York at Buffalo, Department of Biology

Professional Organizations and Responsibilities




Post-doctoral representative for the Computational Biology group at St. Jude Children’s Hospital, Memphis, Tn.

American Crystallographic Association

Elected Chair for the YSSIG American Crystallographic Association



40 under 40 Chicago Scientists


Stafford Gradate Fellowship, Hauptman-Woodward Institute