Benjamin Roche

IRD Researcher

International Center for Mathematical and Computational Modeling of Complex Systems (UMI IRD/UPMC UMMISCO)

32, Avenue Henri Varagnat

93143 Bondy Cedex


e-mail :

Phone: +


(25) Roche B., Broutin H., Choisy M., Godreuil S., Constantin de Magny G., Chevaleyre Y., Zucker J.D., Breban R., Cazelles B. Simard F. (in press) A new paradigm for optimal control of infectious diseases: Targeting the pathogen's niche. BMC Public Health.

(24) Roche B., Drake J. M., Bedford T., Stallknecht D. and Rohani P. (in press) Environmental transmission explains the difference of influenza phylodynamics between birds and humans. PLoS Biology.

(23) Moussaoui A., Auger P., Roche B. (in press) Effect of Hawk-Dove Game on the dynamics of two competing species. Acta Biotheoretica.

(22) Constantin de Magny G., Hasan N.A., Roche B. (2014) How community ecology can improve our understanding of cholera dynamics. Frontiers in Microbiology. 5:137.

(21) Garchitorena A., Roche B., Kamgang R., Ossomba J., Babonneau J., Landier J., Fontanet A., Flahault A., Eyangoh S., Guégan J.F., Marsollier L. (2014) Mycobacterium ulcerans Ecological Dynamics and Its Association with Freshwater Ecosystems and Aquatic Communities: Results from a 12-Month Environmental Survey in Cameroon. PLoS Neglected Tropical Diseases. 8(5):e2879.

(20) Vittecoq M., Roche B., Daoust S.P., Ducasse H., Missé D., Abadie J., Labrut S., Renaud F., Gauthier-Clerc M., Thomas F. (2013) Cancer: a missing link in ecosystem functioning ? Trends in Ecology and Evolution28(11):628-635.

(19) Roche B., Benbow M. E., Merritt R., Kimbirauskas R., McIntosh M., Small P. L. C., Williamson H. and Guégan J.F. (2014) Identifying the Achilles’ heel of multi-host pathogens: The concept of keystone “host” species illustrated by Mycobacterium ulcerans transmission. Environmental Research Letters.8(4): 045009.

(18) Thomas F., Fisher D., Fort P., Marie J.-P., Daoust S., Roche B., Grunau C., Cosseau C., Mitta G., Baghdiguian S., Rousset F., Lassus P., Assenat E., Grégoire D., Missé D., Lorz A., Billy F., Vainchenker W., Delhommeau F., Koscielny S., Itzykson R., Tang R., Fava F., Ballesta A., Lepoutre T., Krasinska L., Dulic V., Raynaud P., Blache P., Quittau-Prevostel C., Vignal E., Trauchessec H., Perthame B., Clairambault J., Volpert V., Solary E., Hibner U. and Hochberg M. E. (2013) Applying ecological and evolutionary theory to cancer: a long and winding road. Evolutionary Applications. 6(1):1-10

(17) Roche B., Sprouffske K., Hbid H., Missé D. and Thomas F. (2013) Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations. Evolutionary Applications. 6(1): 109-116.

(16) Constantin de Magny G., Thiaw W., Kumar V., Manga N.M., Diop B.M., Gueye L., Kamara M., Roche B., Murtugudde R., Colwell R.R. (2012) Cholera outbreak in senegal in 2005: was climate a factor? PloS one. 7 (8), e44577

Vittecoq M., Lafferty K. D. , Elguero E., Brodeur J., Gauthier-Clerc M., Miss\'e D., Roche B. and Thomas F. (2012) Cat ownership is neither a strong predictor of Toxoplamsa gondii infection nor a risk factor for brain cancer. Biology Letters. rsbl20120625

(14) Roche B., Hochberg M.E., Caulin A.F., Maley C.C., Gatenby R.A., Missé D. and Thomas F. (2012) Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 12:387.

(13) Roche B., Dobson A.P., Rohani P. and Guégan J.F. (2013)  Community organization may drive disease patterns for vector-borne pathogens. The American Naturalist. 181(1): 1-11.

(12) Thomas F., Elguero E., Brodeur J., Roche B., Missé D. and Raymond M (2012) Malignancies and high birth weight in human: which cancers could result from antagonistic pleiotropy? Journal of Evolutionary Medicine. 1: 5

(11) Roche B., Dobson A.P., Guégan J.F. and Rohani P. (2012) Community ecology and epidemiology of infectious diseases: a framework to study pathogen transmission through host communities. Philosophical Transactions of the Royal Society: Biological Sciences. 367:1604.

(10) Vittecoq M., Elguero E., Lafferty K.D., Roche B., Brodeur J., Gauthier-Clerc M., Missé D., Thomas F. (2012) Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France. Infection, Genetics and Evolution. 12:496–498 [Link]

(9) Roche B., Drake J.M. and Rohani P. (2011) The curse of the pharaoh revisited: Evolutionary bi-stability in environmentally transmitted pathogens. Ecology Letters. 14(6):569-575 [Link]

(8) Roche B., Drake J.M. and Rohani P. (2011An agent-based model to study the epidemiological and evolutionary dynamics of influenza viruses. BMC Bioinformatics. 12:87 [Link]

(7) Roche B. and Guégan J.F. (2011

Ecosystem dynamics, biological diversity and emerging infectious diseases

Comptes Rendus Biologie. 334:385-392 [Link]

(6) Ottaviani D., de la Rocque S., Khomenko S., Gilbert M., Newman S., Roche B., Schwabenbauer K., Pinto J., Slingenbergh J. (2010) HPAI H5N1 virus in Europe survives during the winter at the cold limit of the migratory waterfowl distribution. EcoHealth. 7(2):226-236 [Link]

(5) Roche B. and Rohani P. (2009) Environmental transmission scrambles coexistence patterns for Avian Influenza Viruses. Epidemics. 2(2):92-98 [Link]

(4) Roche B., Lebarbenchon C., Gauthier-Clerc M., Chang C.M., Thomas F., Renaud F., van der Werf S. and Guégan J.F. (2009). Water-borne transmission drives avian influenza dynamics in wild birds: the case of the 2005-2006 epidemics in the Camargue area  Infection, Genetics and Evolution. 9:800-805 [Link]

(3) Roche B., Guégan J.F., Bousquet F. (2008) Multi-agent systems in epidemiology: A first step for computational biology in the study of vector-borne disease transmission (2008). BMC BioInformatics. 9:435 [Link]

(2) Lefèvre T., Roche B., Poulin R., Hurd H., Renaud F. and Thomas F. (2008) Exploiting host compensatory responses: The must of manipulation? Trends in Parasitology. 24(10): 435-439 [Link]

(1) Lebarbenchon C., Van Der Werf S., Thomas F., Aubin J.T., Azebi S., Cuvelier F., Jeannin P., Roca V., Chang C.-M., Kayser Y., Roche B., Guégan J.F., Renaud F., Gauthier-Clerc M.  (2007)  Absence of detection of highly pathogenic H5N1 in migratory waterfowl in southern France in 2005-2006. Infection, Genetics and Evolution, 7(5): 604-608, September 2007. [Link]

Scientic contributions and book chapters:

Roche B. and Guégan J.F. (2010) Biodiversity and infectious diseases in Ecology and Evolution (Gauthier-Clerc M. and Thomas F.). In Press. French textbook.

Franc A., Peyrard N. and Roche B. (2008)  Infectious diseases in networks  in Introduction to quantitative epidemiology of infectious diseases (Guégan J.F. and Choisy M. eds.).French textbook.

Roche B. and Guégan J.F. (2008)  Community epidemiology: An history of mediation between ecosystems and microbes in Introduction to quantitative epidemiology of infectious diseases (Guégan J.F. and Choisy M. eds.). French textbook. 

[Roche B., Guégan J.-F., between other participants]. (2006) La biodiversité peut protéger des maladies. In: Biodiversité: Focus. CNRS, Paris, France. [PDF]



Roche B., Benbow M.E. and Guégan J.F. Modeling transmission of Mycobacterium ulcerans through local food webs. Annual meeting on Buruli Ulcer Initiative, 31 March - 2 April 2008, Geneva, International Conference Center, Switzerland. (Oral communication).

Roche B.
and Guégan J.F. Avian influenza is water-borne transmitted. Workshop ``Shared traits, extended phenotypes or GxGxE interactions'', 5 December 2007, Paris, France (Oral communication).

Roche B.
and Guégan J.F. Ecosystem dynamics may drive disease dynamics in wildlife. Seminar at NSF/NIH Fogarty Center, 27 August 2007, Washington D.C., USA (Oral communication). Invited

Roche B.
and Guégan J.F. Community structure and composition: Implications for wildlife disease dynamics. ESA Annual meeting, 5-10 August 2007, San Jose, USA (Oral communication).

Roche B. and Guégan J.-F. (2006) Spatial behavior of multi-host vector-borne diseases. Ecology and Evolution of Infectious Diseases, Penn State, USA ([posterEEID.pdf])

Roche B. and Guégan J.-F. (2006) Impact of community composition and structure on disease dynamics in wildlife. EcoHealth, Madison, USA ([presentationMadison.pdf])