Prof. Finn Werner

Principle Investigator and Senior Lecturer



Tel.: 0044 20 7679 0147
Fax: 0044 20 7679 7193


Education
-2002: PhD, Imperial College of Science, Technology and Medicine, London, UK
-1993: BSc, University of Copenhagen, Denmark 


Awards & Honors
-2011: Wellcome Trust New Investigator Awards


Workshop & Conference organisations
-2014: 76th Harden Conference: Total Transcription
-2014: XIIth Archaea UK Workshop
-2012: Gordon Conference: Molecular Biology of Archaea 3
-2011: Cold Spring Harbor Conference: Mechanism of Eukaryotic Transcription, Workshop
-2010: 69th Harden Conference: RNAP 2010


Selected publications

- Grohmann, D, Nagy J, Chakraborty A, Klose D, Fielden D, Ebright RH, Michaelis J, Werner F.  (2011). The initiation factor TFE and the elongation factor Spt4/5 compete for the RNAP clamp during transcription initiation and elongation. Mol Cell. 43(2):263-74.

- Werner F. and Grohmann D. (2010). Evolution of the RNA polymerases in the three domains of life. Nat Rev Microbiol. 9(2):85-98. 

- Grohmann D, Klose D, Klare JP, Kay CW, Steinhoff HJ, Werner F. (2010). RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. J Am Chem Soc. 132(17):5954-5.

- Hirtreiter A, Damsma GE, Cheung AC, Klose D, Grohmann D, Vojnic E, Martin AC, Cramer P, Werner F. (2010). Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. Nucleic Acids Res. 38(12):4040-51.

- Grohmann D, Hirtreiter A, Werner F. (2009). RNAP subunits F/E (RPB4/7) are stably associated with archaeal RNA polymerase: using fluorescence anisotropy to monitor RNAP assembly in vitro. Biochem J. 421(3):339-43

- Ouhammouch M, Werner F, Weinzierl RO, Geiduschek EP. (2004). A fully recombinant system for activator-dependent archaeal transcription. J Biol Chem. 279(50):51719-21.

- Werner F, Weinzierl RO. (2002). A recombinant RNA polymerase II-like enzyme capable of promoter-specific transcription. Mol Cell. 10(3):635-46.PMID: 12408830

- Todone F, Brick P, Werner F, Weinzierl RO, Onesti S. (2001). Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.  Mol Cell. 8(5):1137-43.PMID: 11741548


link to pubmed