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Samuel J. Stellpflug


Samuel J Stellpflug, MD
Director, Twin Cities Medical Toxicology Fellowship
Asst. Dir.
, Regions Hospital Toxicology Eduction and Clinical Services

Faculty Physician, Emergency Medicine and Clinical Toxicology, Regions
Asst. Prof. of Emergency Medicine, University of Minnesota Medical School
Toxicologist Consultant, Hennepin Regional Poison Center

Board Certification: Medical Toxicology, Emergency Medicine
Fellowship: Medical Toxicology, Regions Hospital / Hennepin Regional Poison Center
Residency: Emergency Medicine, Regions Hospital
Medical School: University of Wisconsin
Undergraduate: Marquette University


PubMed-Indexed Journal Manuscripts:

Stellpflug SJ, Kealey SE, Hegarty CB, Janis GC. 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): Clinical Case with Unique Confirmatory Testing. J Med Toxicol 2013. [Epub ahead of print].

Stellpflug SJ
, Gardner RL, Leroy JM, Ellsworth H, Zwank MD. Hydroxocobalamin Hinders Hemodialysis. Am J Kidney Dis 2013;62:395.

Cole JB, Stellpflug SJ, Ellsworth H, Anderson CP, Engebretsen KM, Holger JS.
A Blinded, Randomized, Controlled Trial of Three Doses of High Dose Insulin in Poison-Induced Cardiogenic Shock. Clin Toxicol 2013;51:201-7.

Vang Dean B, Stellpflug SJ, Burnett A, Engebretsen KM. 2C or not 2C: Phenethylamine Designer Drug Review. J Med Toxicol 2013;9:172-8.
 
Wiegand TJ, Wax PM, Schwartz T, Finkelstein Y, Gorodetsky R, Brent J; Toxicology Investigators Consortium Case Registry Investigators. The Toxicology Investigators Consortium Case Registry--the 2011 experience. J Med Toxicol 2012;8:360-77. (no authorship on paper, database contributor).

Evens ZN, Stellpflug SJ. Holiday Plants with Toxic Misconceptions. West J Emerg Med 2012;13:538-42.

Ellsworth H, Stellpflug SJ, Cole JB, Dolan JA, Harris CR. A Life-Threatening Flecainide Overdose Treated with Intravenous Fat Emulsion. Pacing Clin Electrophysiol 2012;36:e87-9.

Cole JB, Stellpflug SJ, Gross EA, Smith SW. Response to "The First Published Case of a Pediatric Diphenhydramine Overdose Whose Electrocardiogram Shows Terminal 40-Millisecond Frontal Plane QRS Axis Deviation". Pediatr Emerg Care 2012 Aug;28(8):833.

Olives TD, Orozco BS, Stellpflug SJ. Bath Salts: The Ivory Wave of Trouble. West J Emerg Med 2011;13:58-62.

Stellpflug SJ, Cole JB, Isaacson BA, Lintner CP, Bilden EF. Massive Atropine Eye Drop Ingestion Treated with High-Dose Physostigmine to Avoid Intubation. West J Emerg Med 2011;13:77-79.

Cole JB, Stellpflug SJ, Gross EA, Smith SW. Wide Complex Tachycardia in a Pediatric Diphenhydramine Overdose Treated with Sodium Bicarbonate.  Pediatr Emerg Care 2011;12:1175-7.


Stellpflug SJ, Fritzlar SJ, Cole JB, Engebretsen KM, Holger JS. Response to Letter to the Editor on Article: Stellpflug SJ, Fritzlar SJ, Cole JB, Engebretsen KM, Holger JS. Cardiotoxic Overdose Treated with Intravenous Fat Emulsion and High-dose Insulin in the Setting of Hypertrophic Cardiomyopathy. J Med Toxicol 2011; 7(2):151-3. J Med Toxicol 2011;7:337-8.

Holger JS, Stellpflug SJ, Cole JB, Harris CR, Engebretsen KM. High Dose Insulin: A Consecutive Case Series in Toxin-Induced Cardiogenic Shock. Clin Toxicol 2011;49:653-8.
 
Cole JB, Stellpflug SJ, Lintner CP. What toxicity may result from the xenobiotic responsible for the finding on this plain film?  Answer: Reduced iron, found in heating pads and instant hand warmers, may result in elevated serum iron concentrations and subsequent iron toxicity. J Med Toxicol 2011;4:327-8.
 
Cole JB, Stellpflug SJ, Ellsworth H, Harris CR.  Reversal of Quetiapine-Induced Altered Mental Status With Physostigmine.  Am J Emerg Med 2011;30:950-3.

Stellpflug SJ. Transaminitis: The Lab Test That Has Inflammation. J Med Toxicol 2011;7:252-3.
 
Stellpflug SJ, Roth EB, Richards ME.  Unique Configuration of the Four Lumen Esophagogastric Tamponade Tube (Minnesota Tube) for the Control of Massive Upper GI Bleeding.  Emerg Med J 2011;28:908.
 
Stellpflug SJ, Fritzlar SJ, Cole JB, Engebretsen KM, Holger JS. Cardiotoxic overdose treated with intravenous fat emulsion and high dose insulin in the setting of hypertrophic cardiomyopathy. J Med Toxicol 2011;7(2):151-3.
 
Engebretsen KM, Morgan M, Stellpflug SJ, Cole JB, Holger JS, Anderson C.  Addition of Phenylephrine to High-Dose Insulin in Dihydropyridine Overdose Does Not Improve Outcome.  Clin Toxicol 2010;48(8):806-812.

Stellpflug SJ
, Cole JB, Harris CR.  "I Shouldn't Have Had Dessert..."  A Moonflower Seed Ingestion.  West J Emerg Med 2010;11(2):21.


Stellpflug SJ, Roberts DJ.  Which xenobiotic(s) could be responsible for the radiographic findings below? : Answer: Any proconvulsant xenobiotic, in this case tramadol, bupropion, and nortriptyline.  J Med Toxicol 2010;6(1):72-3.

Stellpflug SJ, Harris CR, Engebretsen KM, Cole JB, Holger JS.  Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high dose insulin.  Clin Toxicol 2010;48(3):227-9.

Stellpflug SJ, Harris CR.  What Signs and Symptoms Would Be Expected After Ingestion of this Plant?  J Med Toxicol 2009;5(2):62,90-91.

Book Chapters:

Thompson S, Epter M, Stellpflug SJ.  GI Decontamination. Chapter in Kazzi and Shih et al (eds).  The AAEM/RSA Toxicology Handbook, Second Edition. United Press; 2011.

Harris CR, Stellpflug SJ.  Suspected Intoxication and Overdose.  In: Brotman DJ, McKean S, eds.  The Principles and Practice of Hospital Medicine.  New York, NY: Americal College of Physicians and McGraw Hill; 2011: ***.


Stellpflug SJ
, Holger J, Smith SW. Electrocardiographic Silent Areas of the Heart. In: Brady W, Truwit J, eds. Critical Decisions in Emergency and Acute Care Electrocardiography. Oxford, UK: Blackwell Publishing; 2009: 85-91.

Stellpflug SJ, Holger J, Smith SW. The Role of the ECG in ACS. In: Brady W, Truwit J, eds. Critical Decisions in Emergency and Acute Care Electrocardiography. Oxford, UK: Blackwell Publishing; 2009: 167-175.


Electronic Peer Reviewed Publications:

Evens Z, Stellpflug SJ. Holiday Plants With Toxic Misconceptions. ACEP Toxicology Section Newsletter, December 2011.

Laes J, Stellpflug SJ. Toxic Leukoencephalopathy. ACEP Toxicology Section Newsletter, September 2011.


Evens ZN, Stellpflug SJ. Dabigatran etexilate (Pradaxa): anticoagulant and thrombin inhibitor. ACEP Toxicology Section Newsletter, September 2011.

Cole JB, Stellpflug SJ. Physostigmine: It’s Time to Start Using it…Again. ACEP Toxicology Section Newsletter, June 2011.

Olives TD, Orozco BS, Stellpflug SJ.  Bath Salts Update: Meow Meow and MTV.  ACEP Toxicology Section Newsletter, March 2011.


Ellsworth H, Stellpflug SJ.  Déjà vu, Another Designer Drug: Synthetic Cannabinoids.  ACEP Toxicology Section Newsletter, March 2011.


Dahl EJ, Katzung KL, Gardner RL, Stellpflug SJ. Don’t Underestimate These Antidepressants…It Could Prove To Be A Devastating Mistake. ACEP Toxicology Section Newsletter, September 2011.


Abstracts, Conference Poster Presentations, Brief Oral Presentations

Willaert A , Orozco BS , Maslonka K , McNamara J , Cole JB , Stellpflug SJ. Surfactant administration as treatment for respiratory failure following hydrocarbon aspiration.  Clin Toxicol 2013;51:590-1. Abstract #37. Poster presentation, North American Congress of Clinical Toxicology, Atlanta, GA, 2013.

Stellpflug SJ, Floan AJ, Lee SC, Cole JB. Hydroxychloroquine overdose treated successfully with intravenous fat emulsion. Clin Toxicol 2013;51:652. Abstract #172. Poster presentation, North American Congress of Clinical Toxicology, Atlanta, GA, 2013.

Le D, Nguyen A, Stellpflug SJ, Janis G. Detection and Metabolic Characterization of the Hallucinogenic Compound 25I-NBOMe in Biological samples via LC-MS. Poster presentation at the American Society of Mass Spectrometry, Minneapolis, MN, June 9-13, 2013.

Orozco B, Evens Z, Engebretsen K, Holger JS, Stellpflug S. J Med Toxicol 2013; early online publication (abstract).  Poster presentation and oral presentation (by Dr. Orozco) at the ACMT Annual Scientific Meeting, San Juan, Puerto Rico, March 2013.

Stellpflug SJ. Ankle pain and dystrophic calcification.  Clinical Photo Competition (peer-reviewed and chosen for display). American Academy of Emergency Medicine (AAEM) Scientific Assembly, Las Vegas, NV, February 9-13, 2013.

Stellpflug SJ, Gardner RL, Leroy JM, Zwank MD. Hydroxocobalamin hinders hemodialysis. Clin Toxicol 2012:50;583. Abstract #21. Poster presentation, North American Congress of Clinical Toxicology, Las Vegas, October 1-6, 2012.

Melson T, Orozco BS, Hess JM, Cole JB, Stellpflug SJ. The role of early notification from a social networking in intentional cyanide ingestion. Clin Toxicol 2012:50;677. Abstract #230. Poster presentation, North American Congress of Clinical Toxicology, Las Vegas, October 1-6, 2012.

Orozco BS, Engebretsen KM, Stellpflug SJ, Ellsworth H. Correlatioin of osmolar gap and ethylene glycol concentration during hemodialysis. Clin Toxicol 2012:50;700. Abstract #280. Poster presentation, Northo American Congress of Clinical Toxicology, Las Vegas, October 1-6, 2012.

Ellsworth H, Faltesek KA, Gardner RL, Stellpflug SJ, Anderson CP, Subramanian AT, Holger JS. A rat model of carbon monoxide toxicity. Acad Emerg Med 2012;19:S366-S367. Poster presentation, Society of Academic Emergency Medicine, Chicago, May 9-12, 2012.

Engebretsen KM, Stellpflug SJ, Cole JB, Holger JS. Anderson CP. Comparison of Vasopressors versus Placebo in Beta Blocker Toxicity in a Porcine Model. Clin Toxicol 2012;50:363. Poster presentation, International Congress of the European Association of Poisons Centres and Clinical Toxicologists,25 May–1 June 2012, London UK.

Cole JB, Engebretsen KM, Hlavenka L, Adams AB, Ellsworth H, Anderson CP, Stellpflug SJ, Holger JS. 10 U/kg/hr of High Dose Insulin is Superior to 1 U/kg/hr in a Blinded, Randomized, Controlled Trial in Poison-Induced Cardiogenic Shock. Poster presentation. American College of Medical Toxicology Spring Meeting, San Diego, March 16-18, 2012.

Cole JB, Engebretsen KM, Hlavenka L, Adams AB, Ellsworth H, Anderson CP, Stellpflug SJ, Holger JS. 10 U/kg/hr of High Dose Insulin is Superior to 1 U/kg/hr in a Blinded, Randomized, Controlled Trial in Poison-Induced Cardiogenic Shock. Clin Toxicol 2011;49:515.  Abstract #1.  Platform presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.

Olives TD, Ellsworth H, Stellpflug SJ, Cole JB.  Surreptitious Steroid Ingestion Resulting in Factitious Cushing's Syndrome: Sometimes Sendouts Make the Diagnosis. Clin Toxicol 2011;49:530.  Abstract #34.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Stellpflug SJ, Cole JB, Isaacson BA, Lintner CP, Bilden EF. Atropine Eye Drop Ingestion Treated with High-Dose Physostigmine. Clin Toxicol 2011;49:534.  Abstract #44.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Cole JB, Ellsworth H, Engebretsen KM, Stellpflug SJ.  Failure of High Dose Insulin and Intravenous Fat Emulsion in 2 patients with Poison-Induced Cardiogenic Shock. Clin Toxicol 2011;49:537-8.  Abstract #55.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Setzer SC, Cole JB, Kwon SK, Stellpflug SJ, Ellsworth H.  Ondansetron Toxicity in a Toddler Resulting in Tachycardia, Altered Mental Status, and QTc Prolongation. Clin Toxicol 2011;49:554.  Abstract #109.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Cole JB, Lloyd RM, Ellswoth H, Stellpflug SJ, Bangh SA. Medical Child Abuse with Ipecac: a Variant of Maunchausen Syndrome by Proxy. Clin Toxicol 2011;49:554.  Abstract #110.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Moser KL, Cole JB, Bangh SA, Ellsworth H, Stellpflug SJ.  Lead Pellet Embedded in the C2 Vertebra of a Child: A Clinical Dilemma. Clin Toxicol 2011;49:557-8.  Abstract #121.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Ellsworth H, Engebretsen KM, Hlavenka LM, Kim AK, Cole JB, Harris CR, Stellpflug SJ. A Cost Comparison of Fomepizole and Hemodialysis in the Treatment of Methanol and Ethylene Glycol Toxicity. Clin Toxicol 2011;49:590-1.  Abstract #229.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.
 
Kwon SK, Ellsworth H, Lintner CP, Stellpflug SJ, Cole, JB.  Massive Amantadine Overdose Resulting in Status Epilepticus and Death. Clin Toxicol 2011;49:614-5.  Abstract #304.  Poster presentation, North American Congress of Clinical Toxicology, Washington DC, September 21-26, 2011.

Ellsworth H, Engebretsen KM, Hlavenka LM, Kim AK, Cole JB, Harris CR, Stellpflug SJ. A Cost Comparison of Fomepizole and Hemodialysis in the Treatment of Methanol and Ethylene Glycol Toxicity. Poster Presentation, SAEM Great Plains Regional Meeting, St Louis, September 10, 2011.

Cole JB, Ellsworth H, Stellpflug SJ. Same Patient, Same Overdose, Different Treatment, Different Outcome.
Poster Presentation, SAEM Great Plains Regional Meeting, St Louis, September 10, 2011.

Stellpflug SJ
, Cole JB, Lintner CP, Kwon SK, Roberts DJ. Diethylene Glycol: A Poison Center Review Of 10 Years Of Pediatric Exposures. Poster presentation, Amercian College of Medical Toxicology Spring Meeting, Clearwater Beach, March 18-20, 2011.

Stellpflug SJ
, Cole JB, Lintner CP, Kwon SK, Roberts DJ. Diethylene Glycol: A Poison Center Review Of 10 Years Of Pediatric Exposures. Clin Toxicol 2010;48(6):606.  Abstract #11. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.  Oral Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.

Stellpflug SJ
, Fritzlar SJ, Cole JB, Engebretsen KM, Holger JS. Overdose of Diltiazem, Metoprolol, and Amiodarone Treated Successfully with Intravenous Fat Emulsion and High Dose Insulin in an Awake Patient. Clin Toxicol 2010;48(6):612.  Abstract #38. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.

Stellpflug SJ
, Cole JB, Dolan JA, Setzer SC, Moser KL, Harris CR. Life-Threatening Flecainide Overdose Treated with Intravenous Fat Emulsion. Clin Toxicol 2010;48(6):612.  Abstract #41. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.

Holger JS, Engebretsen KM, Stellpflug SJ, Cole JB, Harris CR. High dose insulin case series. Clin Toxicol 2010;48(6):613.  Abstract #45. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Lintner CP, Kwon SK, Brandt R, Cole JB, Stellpflug SJ. Parachuting of Water-Extracted Dextromethorphan. Clin Toxicol 2010;48(6):617.  Abstract #61. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Cole JB, Stellpflug SJ, Karpas A, Roberts DJ. Ingestion of One Lead Fishing Sinker Resulting in Toxic Lead Levels Within Hours. Clin Toxicol 2010;48(6):622.  Abstract #86. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Lintner CP, Kwon SK, Stellpflug SJ, Cole JB. Heating Pad Ingestion with Significant Iron Level Elevation. Clin Toxicol 2010;48(6):623.  Abstract #94. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Stellpflug SJ
, Cole JB, Bangh SA, Roberts DJ. Potentially Lethal Ingestion of DMT and Syrian Rue. Clin Toxicol 2010;48(6):630.  Abstract #124. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.

Cole JB, Stellpflug SJ. Massive Venlafaxine Overdose Resulting in Abdominal Compartment Syndrome. Clin Toxicol 2010;48(6):644.  Abstract #196. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Cole JB, Stellpflug SJ, Gross EA, Smith SW. Wide Complex Tachycardia in a Pediatric Diphenhydramine Overdose Treated with Sodium Bicarbonate. Clin Toxicol 2010;48(6):655.  Abstract #249. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Cole JB, Stellpflug SJ, Moquist KL, Setzer SC, Bilden EF. Massive Hydroxyurea Overdose in a Child Treated with Gastric Lavage and Activated Charcoal. Clin Toxicol 2010;48(6):655.  Abstract #250. Poster Presentation, North American College of Clinical Toxicology, Denver, October 7-12, 2010.


Morgan M, Engebretsen KM, Stellpflug SJ, Vigesaa GS, Dillon CC, Holger JS, Anderson C.  The addition of an alpha-agonist to high-dose insulin in the rescue of swine poisoned with a dihydropyridine does not improve outcome.  Poster presentation, Amercian College of Medical Toxicology Spring Meeting, Scotsdale, March 11-14, 2010.


Stellpflug SJ
, Floan AJ, Lintner CP, Kwon SK.  Accidental Administration of Adult Dose Oxytocin to a Newborn.  Clin Toxicol 2009; 47(7):708.  Abstract #29.  Poster presentation, North American College of Clinical Toxicology, Toronto, September 21-26, 2009.

Kwon SK, Lintner CP, Stellpflug SJ, Bilden E. 15-fold edrophonium overdose. Clin Toxicol 2009; 47(7):708.  Abstract #31.  Poster presentation, North American Congress of Clinical Toxicology, Toronto, September 21-26, 2009.


Stellpflug SJ
, Lintner CP.  Loperamide Overdose in a Neonate and Subsequent Reversal with Naloxone. Clin Toxicol 2009; 47(7):749  Abstract #231.  Poster presentation, North American Congress of Clinical Toxicology, Toronto, September 21-26, 2009.

 
Morgan M, Engebretsen KM, Stellpflug SJ, Vigesaa GS, Dillon CC, Holger JS, Anderson C.  The addition of an alpha-agonist to high-dose insulin in the rescue of swine poisoned with a dihydropyridine does not improve outcome. Clin Toxicol 2009; 47(7):760 Abstract #286.  Poster presentation, North American Congress of Clinical Toxicology, Toronto, September 21-26, 2009. Honored as AAPCC Best Poster Presentation at the Congress.

Harris CR, Stellpflug SJ.  Quetiapine Overdose Resulting in Bowel Infarction, Late Charcoal Aspiration and Death.  Poster presentation, Mediterranean Emergency Medicine Congress, Valencia, Spain, September 14-17, 2009.



Accepted/Pending Publications

Stellpflug SJ, Kerns W II. Antidotes in Depth (A17): High Dose Insulin Therapy. In: Goldfrank L et al (eds) Goldfrank’s Toxicologic Emergencies (in editing for publication).

Stellpflug SJ, Harris CR. Benzodiazepines. Book chapter in Harwood-Nuss Clinical Practice of Emergency Medicine, 6th edition (accepted, in editing for publication).

Stellpflug SJ, Harris CR. Barbiturates. Book chapter in Harwood-Nuss Clinical Practice of Emergency Medicine, 6th edition (accepted, in editing for publication).

Orozco B, Stellpflug SJ. Muscle Relaxants and Other Sedative Hypnotic Agents. Book chapter in Harwood-Nuss Clinical Practice of Emergency Medicine, 6th edition (accepted, in editing for publication).

Stellpflug SJ, Kerns W III. Beta blockers. Book chapter in Hantson and Megarbane’s Poisonings with Cardiotoxicants: Epidemiology, Features, Management, and Exceptional Therapies, 1st edition (accepted, in editing for publication).

Holger JS, Stellpflug SJ, Engebretsen KM, Cole JB, Kerns W. Management of Calcium Channel Overdose (Letter to the Editor on Levine. Sept. Annals). Ann Emerg Med (accepted and pending publication).


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