Faculty‎ > ‎

Joel S. Holger

Joel S. Holger, MD
Director Toxicology Research
Senior Staff, Emergency Medicine, Regions Hospital
Staff Physician: Hudson Hospital
Assistant Professor, University of Minnesota Dept of Emergency Medicine
Associate Research Director, Regions Hospital

Internal Medicine Residency: Abbott Northwestern Hospital, Minneapolis MN
Medical School: University of Minnesota Medical School
Undergraduate Education: Concordia College, Moorhead MN

Peer-Reviewed Articles:

Holger JS, Dries DJ, Barringer KW, Peake BJ, Flottemesch TJ, Marini JJ. Cardiovascular and Metabolic Effects of High-dose Insulin in a Porcine Septic Shock Model. Acad Emerg Med 2010;17:429-435.

Stellpflug SJ, Harris CR, Engebretsen KM, Cole JB, Holger JS. Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high dose insulin. Clin Tox 2010; (article in press).
Ablorth N, Nitu F, Engebretsen K, Thomas DD, Holger JS, Insulin-dependent Rescue From Cardiogenic Shock is Not Mediated By Phospholamban Phosphorylation. Clinical Toxicology 2009, 47:4 296-302.

Holger JS
, Engebretsen KE, Marini J High Dose Insulin in Toxic Cardiogenic Shock. Clinical Toxicology 2009 47:4, 303-307.

Holger JS, Engebretsen KM, Fritzlar SJ, Patten LC, Harris CR, Flottemesch TJ. Insulin Vs. Vasopressin and Epinephrine To Treat B-blocker Toxicity. J Toxicol Clin Toxicol May 2007; 45:396-401.

Johnson NC, Holger JS. Pediatric Otitis Media: The Case For Delayed Antibiotic Treatment. J Emerg Med April 2007; 32(3):279-284.

Holger JS, Engebretsen KM, Obetz CL, Kleven TL, Harris CR. A Comparison of Vasopressin and Glucagon in Beta-blocker Induced Toxicity. J Toxicol Clin Toxicol January 2006; 44:45-51.

Klee G, Holger JS, Kottke TE, Mookadam F. B-type Natriuretic Peptide (BNP) For the Diagnosis and Management of Congestive Heart Failure. Technology Assessment Report #91. Institute for Clinical Systems Improvement. September 1, 2005.

Holger JS, Satterlee PS, Beyer S. Comparison of Nursing Utilization Between Two Methods of Conscious Sedation: Midazolam vs. Propofol. Am J Emerg Med May 2005: 23(3)248-252.

Hofbauer RD, Holger JS. The Use of Cholecystokinin As an Adjunctive Treatment for Toxin Ingestion. J Toxicol Clin Toxicol 2004; 42(1):61-6.

Benjamin M, Holger JS, Carr ME. Personal Preferences Regarding Family Member Presence During Resuscitation. Acad Emerg Med Jul 2004; 11(7):750-3.

Holger JS, Wandersee SC, Hale DB. Cosmetic Outcomes Facial Lacerations Repaired With Tissue Adhesive, Absorbable and Non-absorbable Suture. Am J Emerg Med July 2004:22(4): 254-7.

Lushine KA, Harris CR, Holger JS. Methanol Ingestion: Prevention of Toxic Sequalae After Massive Ingestion. J Emerg Med 2003; 24 (4):433-436.

Holger JS, Lamon RP, Minnegan HJ. The Use of Ultrasound To Determine Ventricular Capture in Transcutaneous Pacing. Am Journal of Emerg Med 2003:21(3):227-229

Holger JS, Harris CR, Engebretsen KM. Physostigmine, Sodium Bicarbonate, or Hypertonic Saline to Treat Diphenhydramine Toxicity. Vet Hume Toxicol 2002 Feb 44(1):1-4.

HolgerJS, Minnigan HJ, Lamon RP, Gornick CG. The Utility of Ultrasound to Determine Ventricular Capture in External Cardiac Pacing. Am J of Emerg Med 2001;19:134-136.

Holger JS, Hale DP, Harris CR, et al. Sedation of Intoxicated, Agitated Patients Requiring CT to Evaluate Head Injury. Am J of Emerg Med 1999; 17:321-323. 


Morgan MW, Engebretsen KM, Stellpflug SJ, Vigesaa GS, Dillon CC, Holger JS, Anderson CP. The Addition of an Alpha-Agonist to High-Dose Insulin in the Rescue of Swine Poisoned with a Dihydropyridine Does Not Improve Outcome. Clinical Toxicology 2009, 47(7):760. Presented at NACCT, San Antonio, TX , September 2009.

Harris CR, Kinnan M, Holger JS. High-Dose Insulin Treatment Recommendations by United States Poison Centers. Acad Emerg Med, April 2009. 16 (4) Supplement 1: S218. Presented at the Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA, May, 2009.

Engebretsen K, Holger J, Morgan M. Are the Cardiovascular Effects of High Dose Insulin in Calcium Channel Blockers and Beta-Blocker Toxicity Mediated by Phopspholamban? Acad Emerg Med 2008; 15(S1) S214. Presented at SAEM Annual Meeting, Washington DC, May 2008.

Engebretsen KM, Holger JS, Harris CR. Therapeutic Misadventure of High Dose Insulin without Adverse Effects. Clinical Toxicology 2008; 46(7):604. Presented at North American Congress of Clinical Toxicology, Toronto, Ontario, CA, September 2008.

Book Chapters:

Stellpflug S, Holger JS, Smith S. What is the Role of the ECG in ACS? In Brady WJ, Truit JD, editors. Critical Decisions in Emergency and Acute Care Electrocardiography. Wiley-Blackwell 2009.

Connelly M, Holger JS, Smith S. What is a Hyperacute T Wave? In Brady, WJ, Truit JD, editors. Critical Decisions in Emergency and Acute Care Electrocardiography. Wiley-Blackwell 2009.

Connelly M, Holger JS, Bertog S. Smith S. What Further Diagnostic Adjuncts to the Standard 12-lead ECG May Help to Diagnose ACS? In Brady WJ, Truit JD, editors. Critical Decisions in Emergency and Acute Care Electrocardiongraphy. Wiley-Blackwell 2009.

Stellpflug S, Holger JS, Smith S. What Are the Electrogardiographically Silent Areas of the Heart? In Brady WJ, Truit JD, editors. Critical Decisions in Emergency and Acute Care Electrocardiography. Wiley-Blackwell 2009.