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The nitty, gritty details. 

Genome:

  • +ssRNA, naked genome is infectious
  • linear, monopartite
  • 5' structural proteins
  • Replication in cytoplasm

Morphology

  • Enveloped icosahedron
  • T=3
  • 1 capsid protein

Transcription

  • 2 mRNAs: genomic and subgenomic 
    • Genomic: ORF-1 codes nonstructural genes
    • Subgenomic: ORF-2 codes structural genes 
  • mRNAs are capped and poly-adenylated

Translation

  • Polyprotein
    • protein products are cleaved from large polyprotein

 

Diagram of Replication Pathways

 Transcription

 The Big Picture of Alphavirus Replication