• Laboratorio de Cromatina y Epigenética

       (Chromatin and Epigenetics Laboratory)

  CINVESTAV-Irapuato


 Dr. Raúl Alvarez-Venegas


 

 

    Líneas de Investigación:
  • Análisis de genes involucrados en el fenómeno de “priming”, en el frijol común (Phaseolus vulgaris L.)
  • Silenciamiento génico, mediado por RNAi, de factores epigenéticos en el frijol común (Phaseolus vulgaris L.)
  • Mecanismos de la regulación epigenética en plantas
  • Epigenética en  plantas de importancia agronómica
  • Estructura y función de genes de la familia Trithorax
  • Interacción Planta-Patógeno
    Research Topics:
  • RNAi-mediated silencing of epigenetic factors in the common bean (Phaseolus vulgaris L.)
  • Analysis of genes involved in the priming phenomenon in the common bean (Phaseolus vulgaris L.)
  • Induction of a primed state of transcription and plant immunity in the common bean
  • Epigenetic mechanisms of gene regulation in plants
  • Epigenetics in plants of agronomic importance
  • Structure and function of genes belonging to the Trithorax family of histone methyltransferases
  • Plant-Pathogen interaction

 

 

 

Dr. Raúl Alvarez-Venegas                 

Profesor Investigador

Cinvestav Unidad Irapuato

Departamento de Ingeniería Genética

Irapuato, Guanajuato, México
ralvarez@ira.cinvestav.mx

 

http://www.researcherid.com/rid/B-1086-2008

http://www.biomedexperts.com/Profile.aspx?n=Raul_Alvarez-Venegas&auid=30220

 

 

 

 

Tenemos lugares para estudiantes de posgrado. 

Contamos con becas para realizar Tesis de Licenciatura.

 

[Openings: graduate students, postdoctoral positions, undergraduate research Thesis]

 

 

Investigador Cinvestav

Investigador Nacional Nivel 2

Miembro de la Sociedad Mexicana de Bioquímica, A.C.

 

 

 

 

B.Sc., Biology, Metropolitan Autonomous University, UAM-X, México City. México.

M.Sc., Biotechnology, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), México City. México.

Ph.D., Biochemistry and Molecular Biology, Department of Biological Sciences, Purdue University, West Lafayette, IN. USA.

Post-doctoral work. (a) University of Nebraska-Lincoln, UNL, Plant Science Initiative, Lincoln NE, USA. (b) UNL, Department of Biological Sciences, Lincoln NE, USA. (c) Pioneer Hi-Bred Production Ltd., Caledon ON, Canada. 

 

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En la actualidad, las áreas de investigación de mayor interés que trabajamos en el laboratorio comprenden: primado de defensa en jitomate y frijol; estructura y función de la cromatina; CRISPR/Cas system; regulación epigenética de los mecanismos de respuesta a patógenos; función de miembros del grupo Trithorax y su relación en la respuesta a organismos patógenos; estudios de la dinámica de la expresión génica; metilación de las histonas; ARN de interferencia (RNAi): mecanismos y análisis; evolución y estudios filogenéticos.

 

 The main research areas in our lab include:  defense-priming in tomato, common bean; CRISPR/Cas system; chromatin structure and function; epigenetic regulation of the interaction plant-pathogen; histone methylation; RNA interference; evolution and phylogenetic analysis.

 

 

 

 

*Publicaciones originales (Recent publications):

 

  • Aarón Barraza, Evelia Lorena Coss-Navarrete, Juan Carlos Vizuet-de-Rueda, Keren Martínez-Aguilar, José Luis Hernández-Chávez, José Juan Ordaz-Ortiz, Robert Winkler, Axel Tiessen, and Raúl Alvarez-Venegas. 2018. Down-regulation of PvTRX1h Increases Nodule Number and Affects Auxin, Starch, and Metabolic Fingerprints in the Common Bean (Phaseolus vulgaris L.). Plant Science 274:45-58. doi: 10.1016/j.plantsci.2018.05.006. Factor de impacto: 3.437

  • Ramírez-Carrasco G, Martínez-Aguilar K and Alvarez-Venegas R. 2017. Transgenerational Defense Priming for Crop Protection Against Plant Pathogens: A Hypothesis. Front. Plant Sci. 8:696. doi: 10.3389/fpls.2017.00696

  • Martínez-Aguilar K, Ramírez-Carrasco G, Hernández-Chávez J, Barraza A, Alvarez-Venegas R. 2016. Use of BABA and INA as activators of a primed state in the common bean (Phaseolus vulgaris L.). Front. Plant Sci. 7:653. doi: 10.3389/fpls.2016.00653

  • Aarón Barraza, José Luis Cabrera-Ponce, Roberto Gamboa-Becerra, Francisco Luna-Martínez, Robert Winkler and Raúl Álvarez-Venegas. The Phaseolus vulgaris PvTRX1h gene regulates plant hormone biosynthesis in embryogenic callus from common bean. Front Plant Sci. 2015 Jul 28;6:577. doi: 10.3389/fpls.2015.00577. eCollection 2015. Research Topic: Recent Advances of Epigenetics in Crop Biotechnology.

    Aarón Barraza, Francisco Luna-Martínez, Joselyn Cristina Chávez-Fuentes, and Raúl Álvarez-Venegas. 2015. Expression profiling and down-regulation of three histone lysine methyltransferase genes (PvATXR3h, PvASHH2h, and PvTRX1h) in the common bean. Plant OMICS Journal. September 2015. ISSN: 1836-3644. 

    Napsucialy-Mendivil S, Alvarez-Venegas R, Shishkova S, and Dubrovsky, JG. 2014. ARABIDOPSIS HOMOLOG of TRITHORAX1 (ATX1) is required for cell production, patterning, and morphogenesis in root development. Journal of Experimental Botany J Exp Bot. 2014 Sep 9. pii: eru355.

    Alvarez-Venegas R. (2014). Title: “Bacterial SET domain proteins and their role in eukaryotic chromatin modification”. Frontiers in Genetics. 2014 Apr 2; 5:65. doi: 10.3389/fgene.2014.00065. eCollection 2014.

    Alvarez-Venegas, R. y Avramova, Z. 2012. Evolution of the PWWP-Domain Encoding Genes in the Plant and Animal Lineages. BMC Evolutionary Biology 12:101 doi:10.1186/1471-2148-12-101. 

    De-la-Peña, C., Rangel-Cano, A. y Alvarez-Venegas, R. 2012. Regulation of disease responsive genes mediated by epigenetic factors: interaction of Arabidopsis-Pseudomonas. Molecular Plant Pathology 13(4): 388–398. Article first published online: 24 OCT 2011 | DOI: 10.1111/j.1364-3703.2011.00757.x. 

    Quiceno-Rico, JM., Camas-Reyes, JA., y Alvarez-Venegas, R. 2012. Molecular cloning and characterization of two Trithorax-Group genes from Phaseolus vulgaris roots and symbiotic nodules. Plant OMICS Journal 5(2): 103-114. ISSN:1836-3644. 

    Valencia-Morales, MP., Camas-Reyes, JA., Cabrera-Ponce, JL., y Alvarez-Venegas, R. 2012. The Arabidopsis thaliana SET-domain-containing protein ASHH1/SDG26 interacts with itself and with distinct histone lysine methyltransferases. Journal of Plant Research 125:679–692. DOI 10.1007/s10265-012-0485-7.

    Saleh, A., Alvarez-Venegas, R., y Avramova, Z. (2008). Dynamic and stable histone H3 methylation patterns at the Arabidopsis FLC and AP1 loci. Gene 423(1): 43–47. 

    Saleh, A., Alvarez-Venegas, R., Yilmaz, M., Oahn-Le, Hou, G., Sadder, M., Al-Abdallat, A., Xia, Y., Lu, G., Ladunga, I., y Avramova, Z. (2008). The highly similar Arabidopsis homologs of trithorax ATX1 and ATX2 encode proteins with divergent biochemical functions. Plant Cell 20(3): 568-579.

    Saleh, A., Alvarez-Venegas, R., y Avramova, Z. (2008). An efficient chromatin immunoprecipitation protocol (ChIP) for studying histone modifications in Arabidopsis plants. Nature Protocols 3(6): 1018-1025.

    Saleh, A., Al-Abdallat, A., Ndamukong, I., Alvarez-Venegas, R. y Avramova, Z. (2007). The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish ‘bivalent chromatin marks’ at the silent AGAMOUS locus. Nucleic Acids Research 35(18): 6290-6296.

    Alvarez-Venegas, R., Al-Abdallat, A., Guo, M., Alfano, J., y Avramova, Z. (2007). Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways. Epigenetics 2(2): 106-117.

    Alvarez-Venegas, R., Sadder, M., Tikhonov, A., y Avramova, Z. (2007). Origin of the bacterial SET domain genes: vertical or horizontal? Molecular Biology and Evolution 24(2):482-497.

    Alvarez-Venegas, R., Yuannan Xia, Guoqing Lu, y Zoya Avramova (2006). Phosphoinositide 5-Phosphate and Phosphoinositide 4-Phosphate Trigger Distinct Specific Responses of Arabidopsis Genes; Genome-Wide Expression Analyses. Plant Signaling and Behavior 1(3): 140-151. 

    Alvarez-Venegas, R., Sadder, M., Hlavacka, A., Baluška, F., Xia, Y., Lu, G., Firsov, A., Sarath, G., Moriyama, H., Dubrovsky, J. y Avramova, Z. (2006). The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. Proceedings of the National Academy of Sciences of the USA 103 (15): 6049–6054. Factor de Impacto = 9.809

    Alvarez-Venegas, R. y Avramova, Z. 2005. Methylation patterns of histone H3 Lys 4, Lys 9 and Lys 27 in transcriptionally active and inactive Arabidopsis genes and in atx1 mutants. Nucleic Acids Research 33(16):5199-5207.

    Alvarez-Venegas, R., Pien, S., Sadder, M., Witmer, X., Grossniklaus, U. y Avramova, Z. 2003. ATX-1, an Arabidopsis Homolog of Trithorax, Activates Flower Homeotic Genes. Current Biology 13(8):627-637.

    Witmer, X., Alvarez-Venegas, R., San-Miguel, P. Danilevskaya, O., y Avramova, Z. 2003. Putative subunits of the maize origin of replication recognition complex ZmORC1-ZmORC5. Nucleic Acids Research 31(2):619-628.

    Alvarez-Venegas, R. y Avramova, Z. 2002. SET-domain genes of the Su(var)3-9, E(z), and Trithorax families. Gene 285:25-37.

    Alvarez-Venegas, R. y Avramova, Z. 2001. Two Arabidopsis homologs of the animal trithorax genes: a new structural domain is a signature feature of the trithorax gene family. Gene 271:215-221.

    Alvarez-Venegas, R., Castellanos-Molina R., Martínez-Bustos F., y Cruz-Mondragón. C. 1997. Cambios en algunos factores antifisiológicos y nutritivos de las semillas de sorgo (Sorghum bicolor (L) Moench) durante la germinación. Archivos Latinoamericanos de Nutrición. 47(2):136-40.

 

 Articulos relacionados (other publications):

 

  • Alvarez-Venegas, R., Zhang, Y., Kraling, K., y Tulsieram, L. 2010. Floración sin Vernalización en Canola de Invierno (Brassica napus): uso del silenciamiento inducido por virus (VIGS) para acelerar la ganancia genética. Revista electrónica Nova Scientia, http://nova_scientia.delasalle.edu.mx/, NÚMERO 5, Vol. 3 (1) Noviembre 2010 -Abril 2011, pp. 29-50. ISSN 2007 – 0705.

  • Alvarez-Venegas, R. (2010). Title: “Regulation by Polycomb and Trithorax Group Proteins in Arabidopsis”. In: The Arabidopsis Book. ISSN: 1543-8120. Rockville, MD, USA. Edited by: American Society of Plant Biologists (ASPB). First published on May 08, 2010; 10.1199/tab.0128, pg(s): 1–20; http://www.bioone.org/doi/pdf/10.1199/tab.0128 Section: Regulatory Processes. http:// www.aspb.org/publications/arabidopsis/

  • Alvarez-Venegas, R. (2013). Title: “A comprehensive genome-wide analysis of the SET domain protein family in plants”. In: Genomics I – Humans, Animals and Plants. Edited by: iConcept Press Ltd. (Hong Kong, China); Chapter 13 (pgs: 29); 1st edition. ISBN: 978-1-922227-03-4 (Hardcover); 978-1-477554-91-3 (Paperback). 344 pages.

  • Alvarez-Venegas, R. (2013). Title: “Chromatin Modifications and Plant Immunity in Phaseolus vulgaris L”. J Plant Biochem Physiol 1(3):112. doi:10.4172/jpbp.1000112. ISSN: 2329-9029. OMICS Publishing Group, Los Angeles CA, USA.

  • Alvarez-Venegas R. (2014). Title: “Bacterial SET domain proteins and their role in eukaryotic chromatin modification”. Frontiers in Genetics. 2014 Apr 2; 5:65. doi: 10.3389/fgene.2014.00065. eCollection 2014.

  • Alvarez-Venegas, R. (2012). “Importancia de los estudios filogenéticos en la biodiversidad de plantas nativas”. En: La Biodiversidad de Guanajuato: Estudio de Estado, vol. II. Capítulo 8: Diversidad de Especies. Ed.: Comisión Nacional para el Conocimiento y Uso de la Biodiversidad (CONABIO)/Instituto de Ecología del Estado de Guanajuato (IEE). México. pp. 109-110. ISBN: 978-607-7607-78-6. Volumen II ISBN: 978-607-7607-80-9.

  • Alvarez-Venegas, R. (2010). Filogenética. Herramienta básica para un sólido manejo ambiental. Revista electrónica “Avance y Perspectiva”, Vol. 3. No. 1. Octubre-Diciembre, 2010. Cinvestav-IPN. México. 

Edición de Libros (Edited books):

  1. Alvarez-Venegas, R (editor), De la Peña, C (co-editor), and Casas-Mollano, JA (co-editor). 2014. Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications. ISBN 978-3-319-07970-7, ISBN 978-3-319-07971-4 (eBook), DOI 10.1007/978-3-319-07971-4. Library of Congress Control Number: 2014942693. Editorial: Springer International Publishing Switzerland (Springer Science+Business Media; www.springer.com).
  2. Associate Editors: De-la-Peña, C., Alvarez-Venegas, R.#, Cullis, C., eds. (2016). Recent Advances of Epigenetics in Crop Biotechnology. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-854-2. ISSN 1664-8714. ISBN 978-2-88919-854-2
  3. Alvarez-Venegas, R# (editor-in-chief), De la Peña, C (co-editor), and Casas-Mollano, JA (co-editor). 2019. Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications. 2nd ed.
   

*Ph.D. Thesis:

  • Raúl Alvarez-Venegas (2002). Putative Gene Homologs of Trithorax in Arabidopsis. Purdue University Graduate School, Department of Biological Sciences, Purdue University, West Lafayette IN, USA. ProQuest Digital Dissertations Publication number: AAT 3099120. ISBN: 0-496-46713-1. Source: DAI-B 64/07, p. 3094, Jan 2004

 

 

Contamos con becas para realizar Tesis de Licenciatura (financiamiento otorgado por el Conacyt a estudiantes sobresalientes en su área).