Recent Publications


S. Roy, V. Smykal, L. Johnson, T.T. Saha, Z. Zou, A.S. Raikhel. Chapter Five – Regulation of Reproductive Processes in Female Mosquitoes. Advances in Insect Physiology Volume 51, 2016, Pages 115–144.

Zhao B, Hou Y, Wang J, Kokoza VA, Saha TT, Wang XL, Lin L, Zou Z, Raikhel AS. Determination of juvenile hormone titers by means of LC-MS/MS/MS and a juvenile hormone-responsive Gal4/UAS system in Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2016 Oct;77:69-77. doi: 10.1016/j.ibmb.2016.08.003. Epub 2016 Aug 12.

Zhang Y, Zhao B, Roy S, Saha TT, Kokoza VA, Li M, Raikhel AS. microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4828-36. doi: 10.1073/pnas.1609792113. Epub 2016 Aug 3.

Saha TT, Shin SW, Dou W, Roy S, Zhao B, Hou Y, Wang XL, Zou Z, Girke T, Raikhel AS. 2016. Hairy and Groucho mediate the action of juvenile hormone receptor Methoprene-tolerant in gene repression. Proc Natl Acad Sci U S A. 2016 Jan 7. pii: 201523838. [Epub ahead of print]

Commentary on Saha et al.


Smykal V, Raikhel AS. 2015. Nutritional control of insect reproduction. Current Opinion in Insect Science. 11: 31-38. doi:10.1016/j.cois.2015.08.003

Lucas KJ, Zhao B, Roy S, Gervaise AL, Raikhel AS. Mosquito-specific microRNA-1890 targets the juvenile hormone-regulated serine protease JHA15 in the female mosquito gut. RNA Biology. Oct 21; Epub ahead of Print

Lucas KJ, Zhao B, Liu S, Raikhel AS. Regulation of physiological processes by microRNAs in insects. Curr Opin Insect Sci. 2015 Oct 1;11:1-7.

Roy S, Saha TT, Johnson L, Zhao B, Ha J, White KP, Girke T, Zou Z, Raikhel AS. Regulation of Gene Expression Patterns in Mosquito Reproduction. PLoS Genet. 2015 Aug 14;11(8):e1005450. doi: 10.1371/journal.pgen.1005450.

Hou Y, Wang XL, Saha TT, Roy S, Zhao B, Raikhel AS, Zou Z. 2015. Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction. PLoS Genet. 2015 Jul 9;11(7):e1005309. doi: 10.1371/journal.pgen.1005309.

Wang YH, Hu Y, Xing LS, Jiang H, Hu SN, Raikhel AS, Zou Z. 2015. A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog. 2015 Jun 9;11(6):e1004931. doi: 10.1371/journal.ppat.1004931.

Lee SH, Oh HW, Fang Y, An SB, Park DS, Song HH, Oh SR, Kim SY, Kim S, Kim N, Raikhel AS, Je YH, Shin SW. 2015. Identification of plant compounds that disrupt the insect juvenile hormone receptor complex. Proc Natl Acad Sci U S A. pii: 201424386. [Epub ahead of print] 

Lucas, K.J., Roy, S., Ha, J. Gervaise, A., Kokoza, V.A. and Raikhel, A.S. 2015. MicroRNA-8 targets the Wingless signaling pathway in the female mosquito fat body to regulate reproductive processes.Proc Natl Acad Sci U S A. 2015. pii: 201424408. [Epub ahead of print]


Liu, S., Lucas, K.J., Roy, S., Ha J., Raikhel, A.S. 2014. Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut. Proc Natl Acad Sci U S A. pii: 201416278. Oct 7;111(40):14460-5. doi: 10.1073/pnas.1416278111.

Zhao, B., Kokoza, V.A., Saha, T.T., Wang, S., Roy, S. and Raikhel A.S. 2014. Regulation of the gut-specific carboxypeptidase: A study using the binary Gal4/UAS system in the mosquito Aedes aegypti. Insect Biochem. Mol. Biol. pii: S0965-1748(14)00133-7. doi: 10.1016/j.ibmb.2014.08.001.


Lucas, K.J., Myles K.M. and Raikhel, A.S. 2013. Small RNAs: a new frontier in mosquito biology. Trends Parasitol. 29: 295-303 

Lucas, K. and Raikhel, A.S. 2013. Insect miRNAs: biogenesis, expression profiling and biological functions. Insect Biochem. Mol. Biol. 43: 24-38.

Zou, Z., Saha, T. T., Roy, S., Shin, S. W., Backman, T.W., Girke, T., White, K.P. and Raikhel, A. S. 2013. Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression. Proc. Natl. Acad. Sci. USA 110: E2173-2181. PMID: 23633570 

Commentary on Zou et al.


Pan, X., Zhou, G., Bian, G., Lu, P., Raikhel, A.S. and Xi, Z. 2012. Wolbachia induces ROS-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti. Proc. Natl. Acad. Sci. USA 109: E23-31

Mane-Padros, D., Cruz, J., Cheng, A. and Raikhel, A. S. 2012. A critical role of the nuclear receptor HR3 in regulation of gonadotrophic cycles of the mosquito Aedes aegypti. Plos One 7(9): e45019

Shin, S. W., Zou, Z., Saha, T. T. and Raikhel, A. S. 2012. The bHLH-PAS heterodimer of Methoprene-tolerant and Cycle mediates circadian expression of juvenile hormone induced mosquito genes. Proc. Natl. Acad. Sci. USA 109: 16576-16581 PMID: 20012454

Cruz, J., Mane-Padros, D., Zou, Z., and Raikhel, A.S. 2012. Distinct roles of heme-liganted nuclear receptor E75, an insect orthologue of vertebrate Rev-erb, in mosquito vitellogenesis. Mol. Cell. Endocrinol. 349: 262-271 PMID:22115961

Roy, S.G. and Raikhel, A.S. 2012. Hormonal and nutritional regulation of the TOR Effector 4E-Binding Protein (4E-BP) in the mosquito Aedes aegypti. The FASEB J. 26, 1334-1342. PMID:22159149



Bryant, B. and Raikhel, A.S. 2011. Programmed autophagy in the mosquito fat body is required for maintaining egg maturation cycles. Plos One 6, 11, e25562

Zou, Z., Souza-Neto, J. A., Xi, Z., Kokoza, V., Shin, S.W., Dimopoulos, G. and Raikhel, A.S. 2011. Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity. Plos Pathog. 7, 11. e1002394 PMID: 22114564.

Shin, S.W., Zou, Z. and Raikhel, A.S. 2011. A new player in the Aedes aegypti immune response: CLSP2 modulates melanization. EMBO Reports 12:938-943.

Kokoza, V.A. and Raikhel, A.S. 2011. Targeted gene expression in the transgenic Aedes aegypti using the binary Gal4-UAS system. Insect Biochem. Mol. Biol. 41: 637-644 PMID: 21536128

Hansen, I. A., Boudko, D.Y, Shiao, S.H., Voronov, D.A., Meleshkevitch, E. A., Drake, L., Aguirre, S., Fox, J., Attardo, G. M. and Raikhel, A. S. 2011. AaCAT1 of the Yellow Fever Mosquito, Aedes aegypti, a novel Histidine-specific Amino Acid Transceptor from the SLC7 Family. J. Biol. Chem. 286: 10803-10813. PMID: 21262963

Neira-Oviedo, M., Tsyganov-Bodounov, A,, Lysett, G. J., Kokoza, V., Raikhel, A.S. and Krzywinski, J. 2011. The RNA-Seq approach to studying the expression of mosquito mitochondrial genes. Insect Mol. Biol. 20: 141-152. PMID: 20958808

Roy, S. G. and Raikhel, A. S. 2011. The small GTPase Rheb is a key component linking amino acid signaling and TOR in the nutritional pathway controlling mosquito egg development. Insect Biochem. Mol. Biol. 41:62-69; PMID: 21035549


Zou, Z., Shin, S.W., Alvarez, K.S., Kokoza, K. and Raikhel, A.S. 2010. Distinct melanization mechanisms in the mosquito Aedes aegypti. Immunity 32:41-53. PMID: 20152169

Bryant, B., Mcdonald, W., and Raikhel, A.S. 2010. miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti. Proc. Natl. Acad. Sci. USA (inaugural article) 107, 22391-22398, PMID: 21115818 

Arensburger P, Megy K, et al. 2010 Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics Science 330: 86 – 88 PMID: 20929810

Bartholomay, L.C.. Waterhouse, R. M. et al. 2010. Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens. Science 330: 88 – 90. PMID: 20929811

Kokoza, V., Ahmed, A., Shin, S. W., Okafor, N., Zou, Z., and Raikhel, A.S. 2010. Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes. Proc. Natl. Acad. Sci. USA 107: 8111-8116 PMID: 20152169   

Significant publications by research areas:

The role of microRNAs in regulating blood digestion and egg maturation

Egg maturation: genes, proteins and receptors

The reproductive role of the insect specific juvenile hormone in female mosquitoes

Molecular basis of the insect steroid hormone 20-hydroxyecdysone action in reproduction of female mosquitoes

Nutritional control of egg maturation



Mosquito immunity and interaction with pathogens

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