Publications

PROVHILO

Rationale and study design of PROVHILO - a worldwide multicenter randomized controlled trial on protective ventilation during general anesthesia for open abdominal surgery. Hemmes SN, Severgnini P, Jaber S, Canet J, Wrigge H, Hiesmayr M, Tschernko EM, Hollmann MW, Binnekade JM, Hedenstierna G, Putensen C, de Abreu MG, Pelosi P, Schultz MJ. Trials. 2011 May;12:111

Higher versus lower positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. The PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology. Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ for the PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology. Lancet. 2014 Aug; 384:495

Accompanying editorial in Lancet. Lancet. 2014 Aug; 384:472

Correspondence. Lancet. 2014 Nov; 384:167

Recommended reading. F1000 Prime Recommended Articles 2014

Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications. Serpa Neto A, Campos PP, Hemmes SN, Bos LD, Bluth T, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Melo MF, Weingarten TN, Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ; PROVE Network Investigators. European Journal of Anaesthesiol. 2017; Feb; 34:229

Respiratory System Mechanics During Low Versus High Positive End-Expiratory Pressure in Open Abdominal Surgery: A Substudy of PROVHILO Randomized Controlled Trial. D'Antini D, Huhle R, Herrmann J, Sulemanji DS, Oto J, Raimondo P, Mirabella L, Hemmes SNT, Schultz MJ, Pelosi P, Kaczka DW, Vidal Melo MF, Gama de Abreu M, Cinnella G; European Society of Anaesthesiology and the PROtective VEntilation Network. Anesth Analg. 2017 Jun; in press

Ventilation with high versus low peep levels during general anaesthesia for open abdominal surgery does not affect postoperative spirometry: A randomised clinical trial. Treschan TA, Schaefer M, Kemper J, Bastin B, Kienbaum P, Pannen B, Hemmes SN, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network Investigators. Eur J Anaesthesiol. 2017 Aug;34(8):534


LAS VEGAS

ESA Clinical Trials Network 2012: LAS VEGAS - Local Assessment of Ventilatory Management during General Anaesthesia for Surgery and its effects on Postoperative Pulmonary Complications: a prospective, observational, international, multicentre cohort study. Hemmes SN, de Abreu MG, Pelosi P, Schultz MJ. Eur J Anaesthesiol. 2013 May; 30:205


Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries. 
LAS VEGAS investigators. Eur J Anaesthesiol. 2017 Aug; 34:492


PRoVENT

Rationale and study design of PRoVENT – an International Multicenter Observational Study on Practice of Ventilation in Critically Ill Patients Without ARDS. Serpa Neto A, Barbas CS, Artigas-Raventós A, Canet J, Determann RM, Dixon B, Hermans G, Hiesmayr M, Tschernko EM, Jaber S, Martin-Loeches I, Putensen C, Schmid W, Smith R, Severgnini P, Hedenstierna G, Hollmann MW, Mills GH, Vidal-Melo MF, Pearse R, Treschan TA, Wrigge H, Binnekade JM, Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ. Journal of Clinical Trials 2013; 3:4

Epidemiology, practice of ventilation and outcome for patients at risk of ARDS I intensive care units in 16 countries. Serpa Neto A, Barbas CS, Artigas-Raventós A, Canet J, Determann RM, Dixon B, Hermans G, Hiesmayr M, Tschernko EM, Jaber S, Martin-Loeches I, Putensen C, Schmid W, Smith R, Severgnini P, Hedenstierna G, Hollmann MW, Mills GH, Vidal-Melo MF, Pearse R, Treschan TA, Wrigge H, Binnekade JM, Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ. Lancet RM 2016 November; 4:882


HEPBURN

HEPBURN - investigating the efficacy and safety of nebulized heparin versus placebo in burn patients with inhalation trauma: study protocol for a multi-center randomized controlled trial. Glas GJ, Muller J, Binnekade JM, Cleffken B, Colpaert K, Dixon B, Juffermans NP, Knape P, Levi MM, Loef BG, Mackie DP, Malbrain M, Schultz MJ, van der Sluijs KF. 
TRIALS 2014; 15:91

Coagulopathy in Patients with Severe Burns. Glas GG, Levi M, Schultz MJ. J Thromb Haemost 2016; 14:865

Nebulized heparin for patients under mechanical ventilation: an individual patient data meta-analysis. Glas GJ, Serpa Neto A, Horn J, Cochran A, Dixon B, Elamin EM, Faraklas I, Dissanaike S, Miller AC, Schultz MJ. Ann Intensive Care 2016; 6:33


ViPS

Rationale and Study Design of ViPS – An international multicenter randomized controlled open trial on variable pressure support for weaning from mechanical ventilation. Kiss T, Uhlig C, Markstaller K, Ullrich R, Jaber S, Mancebo J, Santos JA, Camporota L, Beale R, Schettino G, Saddy F, Vallverdú I, Wiedemann B, Koch T, Schultz MJ, Pelosi P, Gama de Abreu M. Trials 2013; 14:363


PROVAR

Rationale and study design of PROVAR – A randomized controlled trial on the effects of variable versus conventional lung protective mechanical ventilation during open abdominal surgery. Spieth PM, Güldner A, Uhlig C, Bluth T, Kiss T, Schultz MJ, Pelosi P, Koch T, Gama de Abreu M. Trials 2014; 15:155


METAANALYSIS of studies of protective ventilation

Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. 
Serpa Neto A, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Pasqualucci Mde O, Damasceno MC, Schultz MJ. JAMA. 2012 Oct; 308:1651


METAANALYSES of studies of ventilation in the intensive care unit

Ventilation with lower tidal volumes for critically ill patients without the acute respiratory distress syndrome – a systematic translational review and meta–analysis. Serpa Neto A, Nagtzaam L, Schultz MJ. Curr Opin Crit Care. 2014 Feb; 20:25

Associations between tidal volume size, duration of ventilation and sedation needs in patients without the acute respiratory distress syndrome; an individual patient data meta-analysis. Serpa Neto A, Simonis FD, Barbas CS, Biehl M, Determann RM, Elmer J, Friedman G, Gajic O, Goldstein JN, Horn J, Juffermans, NP, Linko R, Pinheiro de Oliveira R, Sundar S, Talmor D, Wolthuis EK, Gama de Abreu M, Pelosi P, Schultz MJ, for the PROVENet investigators. Intensive Care Med. 2014 Jul; 40:950

Lung-protective ventilation with lower tidal volumes and development of pulmonary complications in critically ill patient: a systematic review and individual patient data meta-analysis. Serpa Neto A, Simonis FD, Barbas CS, Biehl M, Determann RM, Elmer J, Friedmad J, Gajic O, Goldstein JN, Linko R, Pinheiro de Oliveira R, Sundar S, Talmor D, Wolthuis EK, Gama de Abreu M, Pelosi P, Schultz MJ, for the PROVENet Investigators. Crit Care Med. 2015 Oct; 43:2155


METAANALYSIS of studies of ventilation in the operating room


Intra-operative ventilatory strategies to prevent postoperative pulmonary complications: a meta-analysis. Hemmes SN, Serpa Neto A, Schultz MJ. Curr Opin Anaesthesiol. 2013 Apr;26:126


Protocol for a systematic review and individual patient data meta-analysis of benefit of so-called lung-protective ventilation settings in patients under general anesthesia for surgery. Serpa Neto A, Hemmes SN, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network investigators. Syst Rev. 2014 Jan; 3:2


Mortality and Incidence of Postoperative Lung Injury in abdominal and Thoracic Surgery patients: a systematic review and meta-analysis. Serpa Neto A, Hemmes SN, Barbas CS, Beiderlinden M, Fernandez-Bustamante A, Futier E, Hollmann MW, Jaber S, Kozian A, Licker M, Wen-Qian Lin, Moine P, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ, for the PROVE Network investigators. Lancet RM 2014 Nov; 2:1007


Protective ventilation with lower tidal volumes and high PEEP versus conventional ventilation with high tidal volume and low PEEP in patients under general anesthesia for surgery: A systematic review and individual patient data meta-analysis. Serpa Neto A, Hemmes SN, Barbas CS, Beiderlinden M, Biehl M, Binnekade JM, Canet C, Fernandez-Bustamante A, Futier E, Gajic O, Hedenstierna G, Hollmann MW, Jaber S, Kozian A, Licker M, Lin W-Q, Memtsoudis SG, Reis Miranda D, Moine P, Paparella D, Putensen C, Ranieri M, Scavonetto F, Schilling T, Schmid W, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ, for the PROVE Network investigatorsAnesthesiology 2015 in press

Effects of volatile anesthetics on mortality and postoperative pulmonary and extra-pulmonary complications in patients undergoing surgery: A systematic review and metaanalysis. Uhlig C, Bluth T, Schwarz K, Deckert S, Andreas M, de Hert S, Landoni G, Serpa Neto A, Schultz MJ, Pelosi P, Schmitt J, Gama de Abreu M. Anesthesiology 2016: 124:1230



OPINIONS AND STATEMENTS

What tidal volumes should be used in patients without acute lung injury? Schultz MJ, Haitsma JJ, Slutsky AS, Gajic O. Anesthesiology. 2007 Jun; 106:1226

Standards for definitions and use of outcome measures for clinical effectiveness research in preoperative medicine: European Perioperative Clinical Outcome (EPCO) definitions - A statement from the ESA-ESICM joint taskforce on preoperative outcome measures. Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A, Hoeft A, Walder B, Chew MS, Pearse RM. European Journal of Anaesthesiology. 2014 July; in press 


Intraoperative Protective Mechanical Ventilation for Prevention of Postoperative Pulmonary Complications - A Comprehensive Review of the Role of Tidal Volume, Positive End-Expiratory Pressure and Lung Recruitment Maneuvers. Güldner A, Kiss T, Serpa Neto A, Hemmes SN, Canet J, Spieth P, Rocco PR, Schultz MJ, Pelosi P, Gama de Abreu M. Lancet Respiratory Medicine 2014 Nov; 2:2007


How to ventilate patients without acute respiratory distress syndrome? Serpa Neto A, Simonis FD, Schultz MJ. Curr Opin Crit Care. 2015 Feb; 21:65

Recent advances in mechanical ventilation in patients without acute respiratory distress syndrome. Serpa Neto A, Filho RR, Rocha LL, Schultz MJ. F1000Prime Rep. 2014 Dec; 6:115

Intraoperative Protective Mechanical Ventilation for Prevention of Postoperative Pulmonary Complications - A Comprehensive Review of the Role of Tidal Volume, Positive End-Expiratory Pressure and Lung Recruitment Maneuvers. Güldner A, Kiss T, Serpa Neto A, Hemmes SN, Canet J, Spieth P, Rocco PR, Schultz MJ, Pelosi P, Gama de Abreu M. Anesthesiology 2015 in press

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