Research

標  I_n_n_o_v_a_t_i_o_n is our goal

http://www.sciencedirect.com/science/article/pii/S0003267015005905
Soxhlet extraction is one of the most prominent sample preparation techniques in chemical analysis. Our team developed on-line chromatographic and mass spectrometric strategies for the monitoring of the extraction process. They can be used to evaluate molecular extractability of biological samples and foodstuffs. [read more]

http://pubs.rsc.org/en/content/articlelanding/2015/an/c5an00847f#!divAbstract
Fusion of water-in-oil droplets enables facile and cost-effective optical assays using low-microliter volumes of samples and reagents. [read more]

http://www.nature.com/srep/2015/150130/srep08135/full/srep08135.html
Students from our lab demonstrated the possibility to adjust the level of ATP in a biocatalytic reaction using a feedback control system facilitated by a microcontroller module and program in C++. [read more]

http://pubs.rsc.org/en/content/articlelanding/2015/an/c4an02220c#!divAbstract
3D-printer and open-source electronics were used to construct a simple user-friendly interface for coupling open digital microfluidic chips with mass spectrometer. The platform has been applied to initiation and monitoring of glutathione oxidation in microliter-scale droplets. [read more]

http://www.sciencedirect.com/science/article/pii/S0003267015010570
Internet-of-Things (IoT) enters chemistry labs... What's next? Our team has developed first fully automated liquid-liquid extraction system coupled with mass spectrometry. It communicates with the internet and mobile phone network, interacting with the user by voice and screen. It enables monitoring dynamic processes such as dissolution of pharmaceutical formulations. [read more]
http://onlinelibrary.wiley.com/doi/10.1002/jms.3702/abstract
Micropatch-arrayed pads (MAPA) are introduced as a facile way to probe distributions of topical drugs on the surface of skin. [read more]

http://www.sciencedirect.com/science/article/pii/S0003267016300332
We have disclosed a simple method for profiling microbial aggregates in complex matrices such as probiotic drinks. It is based on sedimentation of bioparticles followed by capillary hydrodynamic separation. The separated cell aggregates are detected by an active pixel sensor, and imaged by on-line and off-line microscopy. [read more]

http://www.sciencedirect.com/science/article/pii/S0956566314006873
Our group members have developed a simple robotic system capable of analyzing samples by mass spectrometry. The device identifies the analyst (by fingerprint) and the sample (by barcode), collects the sample from a drop-off area, performs simple processing (addition of a reagent), injects the sample to mass spectrometer, collects the spectra, and disposes off the sample. It communicates with the outside world by touch-screen and web interfaces. [read more]

http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra04207g#!divAbstract
Computer screen and amateur digital camera were used to obtain spatiotemporal profiles of non-linear chemical processes at different wavelengths. [read moreSee also the highlight in Chemistry World magazine.

http://pubs.rsc.org/en/content/articlelanding/2015/an/c5an01807b#!divAbstract
Our undergraduate project student co-invented a spectrotomography device that enables multi-dimensional profiling of non-homogeneous samples at different wavelengths. It distinguishes "islands" of (bio)molecules and live specimens in three-dimensional space and tracks their dynamics. [read more]