Using the hydrogel micropatch sampling method, skin excretion specimens obtained from 200+ patients and healthy individuals have been screened. The obtained mass spectra reveal numerous metabolites characteristic for a skin disease. The study demonstrates the possibility to conduct non-invasive and rapid metabolic profiling of skin excretions. Mass spectrometry is a convenient readout technique for the hydrogel micropatch probes exposed to skin. [accepted by Clinical Chemistry]
Internet-of-Things (IoT) enters chemistry labs... What's next? Our team has developed first fully automated liquid-liquid extraction system coupled with mass spectrometry.
This automated analytical system communicates with the internet and mobile phone network, interacting with the user by voice and screen. It enables monitoring dynamic processes such as dissolution of pharmaceutical formulations. [read more]
Our undergraduate project student co-invented a spectrotomography device that enables multi-dimensional profiling of non-homogeneous samples at different wavelengths. It distinguishes "islands" of (bio)molecules and live specimens in the three-dimensional space, and tracks their dynamics. [read more]
Micropatch-arrayed pads (MAPA) are introduced as a facile way to probe distributions of topical drugs on the surface of skin. [read more]
We disclose a biochemical timer reaction generating luminescence bursts.
The time of luminescence increase depends on the initial concentration of the trigger molecule (ATP). [read more]
Real-time mass spectrometry facilitates optimization of multi-enzyme biochemical circuits to stabilize adenosine nucleotide levels during in-vitro biosyntheses. [accepted by Proceedings A]
We have disclosed a simple method for profiling microbial aggregates in complex matrices such as probiotic drinks. It is based on sedimentation of bioparticles followed by capillary hydrodynamic separation. The separated cell aggregates are detected by an active pixel sensor, and imaged by on-line and off-line microscopy. [read more]
Fusion of water-in-oil droplets enables facile and cost-effective optical assays using low-microliter volumes of samples and reagents. Microliter droplets merge spontaneously due to hydrostatic forces, and a reaction is initiated. [read more]
Soxhlet extraction is one of the most prominent sample preparation techniques in chemical analysis. Our team developed on-line chromatographic and mass spectrometric strategies for the monitoring of the extraction process. They can be used to evaluate molecular extractability of biological samples and foodstuffs. [read more]
Computer screen and amateur digital camera were used to obtain spatiotemporal profiles of non-linear chemical processes at different wavelengths. [read more] See also the highlight in Chemistry World magazine.