MASS SPECTROMETRYCLINICAL-CHEMISTRY METABOLOMICS AUTOCHEMISTRY - LUMINESCENCE
Urban Lab

We have developed a portable cloud-integrated pen-probe analyzer, based on ion-mobility spectrometry, for in-situ analysis of volatile organic compounds emanating from surfaces. It is capable of semi-automated sample collection, immediate data processing, and uploading results online. It was used to record spectra of real matrices such as foodstuffs. [read more]

The Urban Lab has published a protocol for the use of inexpensive electronic modules in chemistry and biochemistry research[read more]

Simultaneous distillation-extraction (SDE) is used to isolate volatile organic compounds (VOCs) from complex liquid matrices. We have coupled SDE on-line with a gas chromatograph hyphenated with mass spectrometer. This on-line system enables recording real-time extraction profiles for various VOCs present in the extracted samples (e.g. beer). It allows the analysts to make an evidence-based decision on the extraction time for different groups of analytes in order to maximize extraction yield and minimize analyte losses[read more]

The newly developed analytical method allows researchers to study protein folding in response to rapidly changing pH. An autocatalytic enzymatic reaction is employed to ramp up pH. At the same time, alterations to target protein conformation are monitored by mass spectrometry or fluorometry. [read more]

Telechemistry enables remote control of chemistry experiments and data logging via Internet cloud. Setting up remotely controlled experiments is straightforward with the Particle Photon Wi-Fi module. [read more]

Dual sample chamber mass spectrometry system has been developed to follow the release of volatile organic compounds (VOCs) from various organic specimens. The method enables monitoring VOC emanations that accompany microbial growth, fungal morphogenesis, and putrefaction. [read more]

We have developed a flow rate scanner comprising a pump, an inexpensive single-board computer, and an associated Python program. The device enables fast characterization of on-line detection systems (e.g. mass spectrometers). [read more]

In the recent report, we discuss the usefulness of sample flow rate scan in the studies related to protein mass spectrometry. Ramping sample flow rate during mass spectrometric analysis reveals alterations to protein ion charge state distributions. [read more]

Effervescent tablets are used to transfer volatile organic compounds (VOCs) from liquid to gas phase within seconds. This seamless sample preparation is followed by mass spectrometric or gas chromatographic detection. The method is suitable for analysis of volatile solutes in complex samples (e.g. beverages and cosmetics). [read more]

In a recent study on fizzy extraction, we meticulously investigated this technique with the aim to characterize the extraction mechanism. The results presented in the related report can help analysts to predict the occurrence of matrix effects when analyzing real samples. They also provide a basis for increasing extraction efficiency to detect low-abundance analytes. [read more]

Our team has introduced gel-phase microextraction technique for seamless sampling of analytes adsorbed on surfaces prior to mass spectrometric analysis. [read more]

In a recent study, we demonstrated biochemical assays enabled by droplet actuation with acoustic wave. Tiny droplets containing samples and reagents are dispensed onto a hydrophobic thread, moved with the aid of sound, merged, and the reaction product is monitored in real time by a mini-spectrometer. [read more]

The technique of fizzy extraction (invented in our laboratory three years ago) has been coupled with gas chromatography. This hyphenated approach enables fast, sensitive, and selective analysis of volatile organic compounds (VOCs) present in various types of liquid samples. [read more]