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Analytical Mass Spectrometry (質譜分析)


The course is directed to graduate students who specialize or are interested in analytical, pharmaceutical, or clinical chemistry, as well as biochemistry, biotechnology, systems biology, and related areas.

It will provide a comprehensive overview of mass spectrometry technology, methodology, and applications.


Contents (by topic):

1. Introduction

2. Vacuum system


3. Sample interface and ion source


4. Mass analyzer


5. Ion detector


6. * Mid-term exam


7. Identification of molecules


8. Quantitative analysis


9. Hyphenation with other separation techniques


10. Mass spectrometry imaging


11. * Students’ presentations


12. Selected applications


13. * Final exam



* Final mark will be based on the results of the mid-term exam (30%), presentation (30%), and the result of the final exam (40%). Additional points (up to 15%) can be gained for active participation in the class.



Students who have completed the Analytical Chemistry course are encouraged to participate.


Study material:

Handouts will be provided for selected topics.


1) Urban P.L., Chen Y.-C., Wang Y.-S. 2016, Time-Resolved Mass Spectrometry: From Concept to Applications. Wiley, Chichester.

2) de Hoffmann E., Stroobant V. 2007, Mass Spectrometry: Principles and Applications, 3rd Edition. Wiley, Chichester.

Office hour:

Time: Friday, 14:00-15:00.

Place: room 316

Useful links: (This section will be expanded.)


Handouts (for the participants of this course only):

The handouts and other course materials are currently available in the NTHU iLMS website. You have to log in.

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