Papers, Articles, private or public web publications, etc.

This bibliography is a work in progress. We will be pleased to add citations submitted by others.
Please do not link directly to papers -- it is too much work to keep links updated.

Image Analysis, Visualization, and User Interface

Widita R, Holloway L.C.. Simultaneous selection of beam directions for treatment planning and for image reconstruction. International conference on advances in Nuclear Science and Engineering in Conjunction with LKSTN  37-40, (2007).

Tewell M A and Adams R, The PLUNC 3D treatment planning system: a dynamic alternative to commercially available systems. Med Dosim. 29(2): 134-8(2004).

Woel R T, Munley M T, Hollis D, Fan M, Bentel G, Anscher M S, Shafman T, Coleman R E, Jaszczak R J, and Marks L B, The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up. Int J Radiat Oncol Biol Phys. 52(1): 58-67(2002).

Rosenman J, Miller E, Cullip T, and Tracton G. Image registration: An essential part of radiation therapy treatment planning. Int J Radiat Oncol Biol Phys 40(1):197-205, 1998.

Tracton G, Miller E, Rosenman J, et al, Preparing diagnostic 3D images for image registration with planning CT images, Int J of Rad Oncol Biol Phys, 39(2):340, 1997 (abstr).

Sailer SL, Chaney EL, Rosenman JG, Chang SX, Miller EP, Experience with 3D Conformal Treatment Planning, in Teletherapy: Present and Future, J Palta and TR Mackie, eds., Advanced Medical Publishing, Madison, WI: 525-555, 1996.

Chaney EL, Thorn JS, Tracton G, Cullip T, Rosenman JG, and Tepper JE : A Portable Software Tool for Computing Digitally Reconstructed Radiographs. Int J Radiat Oncol Biol Phys 31(2): 491-497 (1995)

Cullip TJ, Symon JR, Rosenman JG, and Chaney EL, Digitally Reconstructed Fluoroscopy and Other Interactive Volume Visualizations in 3D Treatment Planning, Int. J. Radiat. Oncol. Biol. Phys. 27(1): 145-151 (1993)

Chaney E and Pizer S: Defining Anatomical Structures from Medical Images, Seminars in Radiation Oncology 2(4):215-225, 1992.

Sailer S L, Chaney E L, Rosenman J G, Sherouse G W, and Tepper J E, Three Dimensional Treatment Planning at the University of North Carolina, Seminars in Radiation Oncology 1(4):1(4):267-273 (1992)

Fishman E, Magid D, Ney D, Chaney E, Pizer S, Rosenman J, Levin D, Vannier M, Kuhlman J, and Robertson D, Three-Dimensional Imaging: State of the Art, Radiology 181(2):321-337, 1991.

Sherouse G and Chaney E, The Portable Virtual Simulator, Int. J. Radiat. Oncol. Biol. Phys.21(2):475-482 (1991)

Sherouse G, Novins K, and Chaney E, Computation of Digitally Reconstructed Radiographs for Use in Radiotherapy Treatment Design, Int. J. Radiat. Oncol. Biol. Phys.,18(3):651-658 (1990a)

Sherouse G, Bourland D, Reynolds K, McMurry H, Mitchell T, and Chaney E, Virtual Simulation in the Clinical Setting: Some Practical Considerations, Int. J. Radiat. Oncol. Biol. Phys.19(4):1059-1065 (1990b)

Levoy M, Fuchs H, Pizer SM, Rosenman JG, Chaney EL, Sherouse GW, Interrante V, Kiel J, Volume Rendering in Radiation Treatment Planning, Proceedings of the First Conference on Visualization in Biomedical Computing, IEEE Computer Society Press, Los Alamitos, CA, 4-10 (1990)

Sailer SL, Bourland JD, Rosenman JG, Sherouse GW, Chaney EL, and Tepper JE, 3-D Beams Need 3-D Names, Int J Radiat Oncol Biol Phys, 19:797-798, 1990.

Mills PH, Fuchs H, Pizer SM, Rosenman JG: IMEX: A tool for image display and contour management in a windowing environment, Medical Imaging III: Image Capture and Display, RH Schneider, S Dwyer II, and RG Jost, eds, Proceedings of the SPIE 1091:132-142, (1989).

Mosher C, Sherouse G, Chaney E, Rosenman J, 3D Displays and User Interface Design for a Radiation Therapy Treatment Planning CAD Tool, Proc. SPIE Conference on Three-dimensional Imaging and Remote Sensing Imaging, Los Angeles, CA, SPIE Vol 902, 64-71, (1988).

Sherouse G, Mosher C, Novins K, Rosenman J, Chaney E, Virtual Simulation: Concept and Implementation, The Use of Computers in Radiation Therapy, Proceedings of the Ninth International Conference, Elsevier Science Publishers, North Holland, 433-436, (1987).

Mosher C, Sherouse G, Mills P, Novins K, Pizer S, Rosenman J, and Chaney E, The Virtual Simulator, Proceedings of the 1986 Workshop on Interactive Computer Graphics, Assoc. for Comp. Machinery (ACM), New York, 37-42, (1987).

Pizer S, Fuchs H, Mosher C, Lifshitz L, Abram G, Ramanthan S, Whitney B, Rosenman J, Staab E, Chaney E, and Sherouse G, 3D Shaded Graphics in Radiotherapy and Diagnostic Imaging, National Computer Graphics Association Technical Sessions Proceedings, Vol III, 107-113, Anaheim, CA, (1986).

Chaney E, Fuchs H, Pizer S, Rosenman J, Sherouse G, Staab E, and Varia M, A Three-Dimensional Imaging System for Radiotherapy Treatment Planning, Proceedings of the XIV International Conference on Medical and Biomedical Engineering and the VII International Conference on Medical Physics, Medical and Biomedical Engineering and Computing, 23:951-952, (1985)

Pizer S, Fuchs H, Heinz E, Staab E, Chaney E, Austin J, Rosenman J, Bloomberg S, MacHardy E, Mills P, and Strickland D, Interactive Three-dimensional Display of Medical Images. Information Processing and Medical Imaging, Proceedings of the 8th Information Processing and Medical Imaging Conference, Akademisch Ziekenhuis VUB, Brussels, 513-526, (1984).

Dose Simulation and Optimization

Abella V, Miro R, Juste B, Verdu G. Comparison of MCNP5 Dose calculations inside the RANDO Phantom Irradiated with a MLC LinAc Photon Beam against treatment planning system PLUNC. Progress in Nuclear Science and Techonology. 2: 232-236 (2011).

Hissoiny S, Ozell B, and Despres P, A convolution-superposition dose calculation engine for GPUs. Med Phys. 37(3):  1029-37(2010).

Quaranta B P, Das S K, Shafman T D, Light K L, and Marks L B, The utility of non-axial treatment beam orientations for lower lobe lung cancers. J Appl Clin Med Phys. 11(1):  3010(2010).

Reese A S, Das S K, Curie C, and Marks L B, Integral dose conservation in radiotherapy. Med Phys. 36(3):  734-40(2009).

Hissoiny S , and Ozell B  Fast convolution- superposition dose calculation on graphics hardware. Med. Phys36, 1998-2005 (2009).

Kocak Z, Borst G R, Zeng J, Zhou S, Hollis D R, Zhang J, Evans E S, Folz R J, Wong T, Kahn D, Belderbos J S, Lebesque J V, and Marks L B, Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis. Int J Radiat Oncol Biol Phys. 67(1):  178-86(2007).

Horton J K, Halle J S, Chang S X, and Sartor C I, Comparison of three concomitant boost techniques for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 64(1):  168-75(2006).

Yang R, Dai J, Yang Y, and Hu Y, Beam orientation optimization for intensity-modulated radiation therapy using mixed integer programming. Phys Med Biol. 51(15):  3653-66(2006).

Shou Z, Yang Y, Cotrutz C, Levy D, and Xing L, Quantitation of the a priori dosimetric capabilities of spatial points in inverse planning and its significant implication in defining IMRT solution space. Phys Med Biol. 50(7):  1469-82(2005).

Black R D, Scarantino C W, Mann G G, Anscher M S, Ornitz R D, and Nelms B E, An analysis of an implantable dosimeter system for external beam therapy. Int J Radiat Oncol Biol Phys. 63(1):  290-300(2005).

Chang S X , Cullip T J , Deschesne K M, Miller E P  , and Rosenman J G  Compensators: an alternative IMRT delivery technique. Journal of applied clinical medical physics. 5(3): 15-36 (2004).

Krasin, M J , Crawford B T , Zhu Y , Evans E S , Sontag M  R , Kun L  E , Merchant T  E .Intensity-modulated radiation therapy for children with intraocular rentinoblastoma: Protential sparing of the bony orbit. Clin Oncol. 16(3): 215-222 (2004).

Wang C, Dai J, and Hu Y, Optimization of beam orientations and beam weights for conformal radiotherapy using mixed integer programming. Phys Med Biol. 48(24):  4065-76(2003).

Torres I J, Mundt A J, Sweeney P J, Llanes-Macy S, Dunaway L, Castillo M, and Macdonald R L, A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors. Neurology. 60(7):  1113-8(2003).

Chang SX, Cullip TJ, Rosenman JG, Halvorsen PH, and Tepper JE: Dose Optimization via Index-Dose Gradient Minimization, Med Phys 29(6):1130-1146, 2002.

Dai J and Zhu Y, Comparison of two algorithms for determining beam weights and wedge filters. J Appl Clin Med Phys. 3(3):  190-9(2002).

Wu X, Zhu Y. A global optimization method for three dimensional conformal radiotherapy treatment planning. Phys Med and Biol. 46 (1), 107 (2001).

Pugachev A, Li J G, Boyer A L, Hancock S L, Le Q T, Donaldson S S, and Xing L, Role of beam orientation optimization in intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 50(2):  551-60(2001).

Socinski M A, Marks L B, Garst J, Sibley G S, Blackstock W, Turrisi A, Herndon J, Zhou S, Anscher M, Crawford J, Shafman T, and Rosenman J, Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: a preliminary report of a phase I dose escalation trial from the Carolina Conformal Therapy Consortium. Oncologist. 6 Suppl 1:  20-4(2001).

Chang S X, Cullip T J, and Deschesne K M, Intensity modulation delivery techniques: "step & shoot" MLC auto-sequence versus the use of a modulator. Med Phys. 27(5):  948-59(2000).

Dai J and Zhu Y, Selecting beam weight and wedge filter on the basis of dose gradient analysis. Med Phys. 27(8):  1746-52(2000).

Vijayakumar S, Myrianthopoulos L C, Dabrowski J, Pelizzari C A, Rosengarten J, Nguyen A, Vaida F, and Chen G T Y  In the radiotherapy of prostate cancer, technique determines the doses to the penile structures. The Brit J Radiol. 72, 882-888 (1999).

Chang S X, Deschesne K M, Cullip T J, Parker S A, and Earnhart J, A comparison of different intensity modulation treatment techniques for tangential breast irradiation. Int J Radiat Oncol Biol Phys. 45(5):  1305-14(1999).

Marks L B and Sibley G, The rationale and use of three-dimensional radiation treatment planning for lung cancer. Chest. 116(6 Suppl):  539S-545S(1999).

Chaney EL, Cullip TJ, and Gabriel TA, A Monte Carlo Study of Accelerator Head Scatter, Med. Phys. 21(9): 1383-1390 (1994)

Carey EM, Water phantom measurements for verifying 3D dose calculations for a megavoltage photon beam, Masters Thesis, Dept of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, 1991.

Research & Medical Advances Facilitated by PLUNC

Li T, Zhu X, Thongphiew D, Lee W R, Vujaskovic Z, Wu Q, Yin F F, and Wu Q J, On-line adaptive radiation therapy: feasibility and clinical study. J Oncol. 2010:  407236(2010).

Das I.J. Moskvin V, Johnstone P.A. Analysis of treatment planning time among systems and planners for intensity-modulated radiation therapy. J Am Coll Radiol. 6: 514-517 (2009).

Yang R, Dai J, Yang Y, and Hu Yimin. Beam orientation optimization for intensity-modulated radiation therapy using mixed integer programming. Phys Med Biol 51, 3653-3666 (2006).

Rosenman JG, Halle JS, Socinski MA, Deschesne K, Moore DJ, Johnson J, Frasier R, and Morris DE. High dose conformal radiation therapy for treatment of stage IIIA/IIIB non-small cell lung cancer: Technical issues and results of a phase I/ II trial. Int. J. Radiat. Oncol. Biol. Phys. 54(2):348-356, 2002.

Chang S.X., Cullip T.J, and Deschesne K.M.: Intensity modulation delivery techniques: “step and shoot” MLC auto-sequence versus the use of a modulator, Med. Phys 27(5): 948 (2000)

Rosenman J, Sailer S, Sherouse G, Chaney E, and Tepper J, Virtual Simulation: Initial Clinical Results, Int J Radiat Oncol Biol Phys, 20(4):843-852, (1991).