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International Journal of Medicinal Plants

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International Journal of Medicinal Plants, Impact Index: 3.12, ISJN: 6672-4384, Language: English, Category: International Journal, Imprint: Photon

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In Vitro Antisickling Activities of Yellow Passion Fruit (Passiflora 
edulis F. Flavicarpa Deg)
Amujoyegbe O.O.*, Agbedahunsi J. M., Akinpelu B.A., Amujoyegbe B.J., Idu M., Oyedapo O.


Medicinal plants have been a source of succour in the control of many diseases in developing countries. Yellow passion fruit is both an edible and medicinal plant. The aqueous leaf and fruit extracts of P. edulis was phytochemically screened with a view of investigating its biological activities. The in vitro antisickling potential of the leaf and fruit extracts was investigated by using aqueous extracts. In-vitro antisickling activities of these plants’ parts were evaluated using Parahydroxybenzoic acid and normal saline as positive and negative controls respectively. The aqueous extracts of the leaf and gelatinous pulpy juice inside the fruit were assessed for their antisickling activities using the inhibitory and reversal methods. The results showed that their activities had linear increase in inhibitory and reversal activities as the concentration of the aqueous extracts of the parts increased. The aqueous extract of the leaf exhibited the highest activities for inhibitory and reversal activities with 97.18 % and 96.54 % while the juice extract of the fruit have 93.99% and 92.66% respectively. It can be concluded that the Passion leaf is more active in inhibitory and reversal activities compared to the fruit juice.

Synergistic antinociceptive activity of different compositions of 
Panchagavya and Bauhinia variegata Linn. by using Tail immersion 
Rahul Kumar, Kuldip Kumar, Vaishnavee Gupta, Amit Kumar, Triveni, Kishu Tripathi*


Panchagavya, which is an important component of many rituals and Indian traditional systems, is an incredible source for many medicinal substances whose synergistic action has been reported but their scientific data are not available. The main objective is to investigate synergistic antinociceptive activity of panchagavya with ethanolic extract of Bauhinia variegata Linn (EEBV). In the present work, two compositions of Panchagavya as well as the composition of 10%, 50%, 75% of EEBV with Panchagavya 1 (PG1) & Panchagavya 2 (PG2) were prepared, administered every day at dose of 4ml/kg body weight regularly at 9:00 am for 21 days & investigated the role of different composition of Panchagavya and its synergistic antinociceptive with ethanolic extract of Bauhinia variegata Linn (EEBV) by using Tail immersion Model in Swiss albino mice using Diclofenac sodium as an standard drug. The synergistic activity of PG +EEBV might be due to the steroids, terpenes, sesquiterpens, flavonoides, vitamins as present in the PG as well as EEBV which appear to classify work by the abolition of the rate limiting step by the enzyme phospholipase A (PLA2) to liberate arachidonic acid from cell membrane which is then involved in the upregulation of cyclo-oxygenase and lipooxygenase enzyme production. This work will open new avenue for the study of various preparations used in worship because this study has showed the synergistic antinociceptive activity. Further studies may reveal some more pharmacological activities like anti-stress, anthelmintic etc. This will give impetus for the study of various materials used in worship of God which will reveal the logic of materials used in worship.

Cytotoxic activity of anthocyanin-rich extracts from leaf tissue of 
sweet potato (Ipomoea batatas L.) genotype Orissa-3 against human 
leukemia cell lines and human cervical cancer cell lines
Rajeswari L.S.*, Vino T. Cheriyan, Moorthy S.N. Ruby John Anto, Unnikrishnan V.S.


Anthocyanins are polyphenolic ring-based flavonoids, and are widespread in fruits and vegetables of red-blue color. Epidemiological investigations and animal experiments have indicated that anthocyanins may contribute to cancer chemoprevention. Many of the major classes of drugs in current use owe their overall therapeutic effectiveness, but lack of selectivity for tumor cells over normal cells can lead to severe side effects. Extractions of bio active molecules from natural products which can specifically block some targets in tumor cells are in perspective direction in modern medicinal chemistry. Therefore, there is an urgent need to establish a process to assess anticancer drug action, i.e., safety, efficacy, and mechanism of action. In this study, we report some promising results obtained from anthocyanin extract against human cervical cancer cell lines – HeLa and the human leukemia cell lines– K562 characterizing cytotoxicity by MTT assay and nuclear condensation assay.

Anti-cancer and anti-oxidative potential of flaxseed oil against DMBA 
induced skin carcinogenesis in mice
Jyoti Sharma, Ritu Singh, P.K. Goyal*


The present study investigates the chemopreventive potential of flaxseed oil on two stage skin carcinogenesis in mice model. For this, 7, 12-dimethyl benzanthracene (100 μg/100 μL of acetone) is topically applied once as initiator and followed by application of croton oil thrice in a week for 16 weeks. Oral administration of Flaxseed oil (50μL/animal/day) during the peri-initiation stage (Group IV) and the tumor promoting stage (Group V) revealed the appreciable inhibition of the tumor yield to 3.50 and 2.30 (positive control value 5.30), tumor burden to 4.4 and 3.8 (positive control value 5.30) and the cumulative number of papillomas to 35 and 23 (positive control value 53), respectively. Flaxseed oil treatment reduced skin tumor incidence in peri and post-initiation group as 80 and 60%, respectively (positive control 100%). Both these groups showed a significant elevation in antioxidant enzymes and reduced glutathione along with significant inhibition in lipid per oxidation in liver and skin of mice in comparison to carcinogen treated control group. These findings suggest that Flaxseed oil has chemopreventive potential during chemical induced carcinogenesis in mammals.

A Review on Potential Ethnomedicinal Plant Tinospora cordifolia L.
Anita*, Sharma H.P., Patnaik Amit


Tinospora cordifolia (Guduchi) is a large, glabrous, perennial, deciduous, climbing shrub profusely found in India and other Asian countries.It is commonly used in traditional system of medicine for its rejuvenating properties. It contains various bioactive compounds including including alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoids, phenolics, aliphatic compounds, and polysaccharides. These compounds have been reported to have different biological roles in disease conditions thus enabling potential applications in clinical research. Its efficacy has been also recognized by the modern system of medicine. This plant has been known to possess anti-oxidant, antidiabetic, anti-allergic, immunomodulatory, antiinflammatory, anti-cancer and several other properties. The present review summarizes the information concerning the traditional uses, phytochemistry and therapeutic applications of Tinospora cordifolia.

Phenolic content and biological activities of Limonium densiflorum crude 
extract and its methanolic fraction: Influence of genotype and fractionation
ZarKalai Feten*, Boulaaba Mondher, Trabelsi Najla, Waffo Teguo Pierre, Mérillon Jean Michel,
Smaoui Abderrazak, Abdelly Chedly, Ksouri Riadh


In this study, shoot extracts of the traditional medicinal Limoniumdensiflorum, Plantagocrassifolia and  uaedamaritima col lected from the same biotope, were screened for their polyphenol contents and antioxidant capacities. Then a fractionation of the most promising extracts from thesehalophyte species was done for determining the fraction with higher phenolic content and antioxidant activity. Furthermore, the efficiency of the best fraction has been inspected against 5 human pathogenic bacteria and analyzed by HPLC. Results showed that phenolic content and antioxidant activities varied significantly as a function of the species. The highest phenolic content was observed in L. densiflorum (66.8 mg EAG/g DW). Its antioxidant activity was found to be higher than the two others halophytes for 4 complementary systems. Additionally,after fractionation of the interesting halophyte L. densiflorum shoots extract into 5 fractions, F5 showed the best antioxidant activity against all tests and interesting antibacterial capacity against human pathogenic bacteria. The HPLC analysis of F5 revealed its richness on phenolic acids and flavonoids with 4-hydroxybenzoic acid as major compound. Data suggestthat L. densiflorum constitute a new source of safe and inexpensive antioxidants and signal the importance of fractionation as method to better assess biological activities. In conclusion, L. densiflorum could be a natural antibacterial and antioxidant agents used in food preservation and human health. Further studies will be needed to identify all components of F5 to select the most powerful antioxidant and antibacterial purified and safe agents.

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