Pharmacodynamics,Orally ineffective drugs,G protein receptors -
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General Pharmacology


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Pharmacodynamics                                                                                    

Pharmacodynamics
“What the drug does to the body”

Sublingual                                                                                              Lick BI CNN avoids First pass metabolism
Buprenorphine
Isoprenaline
Clonidine
Nifedipine
Nitroglycerine         

Orally Ineffective/Less effective

"Dont put PINS inside mouth!"
Pencillin-G
Insulin
Neostigmine
Streptomycin

Oral drugs-Site of Absorption                                                                          

Acidic drugs-absorbed from stomach
Basic drugs  - absorbed from duodenum
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Oral drugs -forming Insoluble Complexes                                                                

TIAPS  read as “Tie-ups”
Tetracycline with Iron compounds
Antacids/Phenytoin with Sucralfate

G-proteins for receptors                                                                               

"QISS & QIQ" (Kiss and Kick):
 G-proteins and their respective receptors in alphabetical order:
G-protein Q: alpha 1 receptor, G-proteins I: alpha 2 receptor ,
G-proteins S: beta 1 receptor ,G-protein S: beta 2 receptor
&
G-protein Q: M1 receptor, G-protein I: M2 receptor, G-protein Q: M3 receptor.  


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