 Peter Jedlička, MD, PhD NeuroScience Center, Clinical Neuroanatomy (Anatomy I) Johann Wolfgang Goethe-University Theodor-Stern-Kai 7, D-60590 Frankfurt am Main Phone: ++49 (69) 6301 6916 Email: jedlicka @ em . uni-frankfurt . de Research interests My long term interest is to better understand how the complex structure of neurons and dynamical intracellular signaling in dendrites and at synapses affect computational properties of the nervous system. My broader, philosophical motivation is to explore whether it is possible to entirely reduce human cognition to neuronal computation. I use approaches that are based on a close interaction between computational modeling and experimental methods. I am focusing on the following special topics: * GABAergic inhibitory transmission regulates membrane potential dynamics in neuronal cells thereby crucially controlling excitability in the brain. The efficacy of synaptic inhibition is dynamic and strongly depends on ionic driving force for the chloride-permeable receptors. I want to learn more about general rules that govern spatio-temporal ionic dynamics at inhibitory synapses and their effects on dendritic computation. To address this important issue I have recently created a model of chloride accumulation and diffusion in morphologically realistic dendritic trees (Jedlicka et al. Hippocampus 2011, Mohapatra et al. Sci Reports 2016). The model allowed us to study activity-dependent changes of intracellular chloride concentration and their impact on synaptic inhibition. * In my neurophilosophical musings, I am fascinated by the quandary whether scietific exploration of neural mechanisms of mental activity undermines our traditional understanding of personal freedom and responsibilty (Jedlicka TICS 2005) Publications Google Scholar ResearcherID ORCID FrontiersOriginal articlesMohapatra N , Tønnesen J, Vlachos A , Kuner T , Deller T , Nägerl V , Santamaria F, Jedlicka P (2016) Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition. Scientific Reports, 6:23196. doi: 10.1038/srep23196 (IF 5.6) pdfBeining M, Jungenitz T, Radic T, Deller T, Cuntz H* , Jedlicka P*, Schwarzacher SWS* (2016) Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells. Brain Structure & Function doi: 10.1007/s00429-016-1285-y (5-year IF 7.5) pdfPlatschek S, Cuntz H, Vuksic M, Deller T*, Jedlicka P* (2016) A general homeostatic principle following lesion induced dendritic remodeling. Acta Neuropathologica Communications, 4:19, doi 10.1186/s40478-016-0285-8 pdfJedlicka P, Benuskova L, Abraham WC (2015) A voltage-based STDP rule combined with fast BCM-like metaplasticity accounts for LTP and concurrent “heterosynaptic” LTD in the dentate gyrus in vivo. PLOS Computational Biology, 11:e1004588, Impact Factor 4.6 pdfO'Sullivan G*, Jedlicka P*, Chen H-X, Kallbouneh H, Ippolito A, Deller T, Nawrotzki R, Kuhse J, Kalaidzidis Y.L., Kirsch J, Schwarzacher SW, Betz H (2016) Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice. Molecular and Cellular Neuroscience, doi: 10.1016/j.mcn.2016.01.010 (IF 3.8) pdfJedlicka P*, Vnencak M*, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW (2015) Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo. Brain Structure & Function, 220:47-58 pdf (5-year IF 7.5)Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, Müller UC, Deller T*, Jedlicka P* (2015) Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. Journal of Comparative Neurology, 523:1717-1729, (IF 3.2) pdf Lenz M, Platschek S, Priesemann V, Becker D, Willems LM, Ziemann U, Deller T, Müller-Dahlhaus F, Jedlicka P, Vlachos A (2014) Repetitive magnetic stimulation induces plasticity of excitatory postsynapses on proximal dendrites of cultured mouse CA1 pyramidal neurons. Brain Structure & Function, 220:3323-37 (5-year IF 7.5) pdf Rawashdeh O, Jilg A, Jedlicka P, Slawska J, Thomas L, Saade A, Schwarzacher SW, Stehle JH (2014) PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus, 24:712-23 pdf (5-year IF 5.1) Jungenitz T, Radic T, Jedlicka P, Schwarzacher SW (2014) High-frequency stimulation induces gradual immediate early gene expression in maturing adult-generated hippocampal granule cells. Cerebral Cortex, 24: 1845-1857 ((5-year (IF 8.4) pdfBecker D, Willems L, Vnencak M, Zahn N, Schuldt G, Jedlicka P, Maggio N, Deller T, Vlachos A (2012) Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhinohippocampal slice cultures. PLoS One 7(11): e48500 pdf (5-year IF 4) Benuskova L, Jedlicka P (2012) Computational modelling of long-term depression of synaptic weights: insights from STDP, metaplasticity and spontaneous activity. Neural Network World, 22: 161-180 pdf Vlachos A, Becker D, Jedlicka P, Winkels R, Roeper
J, Deller T (2012) Entorhinal
denervation induces homeostatic synaptic scaling of excitatory postsynapses of
dentate granule cells in mouse organotypic slice cultures. PLoS One 7(3):e32883 pdf supplement Jedlicka P, Owen M,
Vnencak M, Tschäpe JA, Hick M, Müller UC, Deller T (2012) Functional
consequences of the lack of amyloid precursor protein in the mouse dentate
gyrus in vivo. Experimental Brain Research 217:441-447 pdf Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J, 29(14):2421-32. pdf, supplement Jedlicka P, Deller, T, Schwarzacher SW (2010) Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus. Journal of Computational Neuroscience, 29:509–519 pdf Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron, 63:628-42 pdf
Jedlicka P, Papadopoulos T, Deller T, Betz H, Schwarzacher SW (2009) Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Molecular and Cellular Neuroscience, 41:94-100 pdf Winkels R*, Jedlicka P*, Weise F, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of ßIV-spectrin mutant mice in vivo. Hippocampus, 19:677-86 pdf Jedlicka P*, Schwarzacher SW*, Winkels R, Kienzler F, Bramham CR, Frotscher M, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst LTP and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus, 19:130-140 pdf Kienzler F, Jedlicka P, Vuksic M, Deller T, Schwarzacher SW (2006) Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse. Brain Res 1085(1):195-8 pdf Review articlesJedlicka P, Deller T (2016) Understanding the role of synaptopodin and the spine apparatus in Hebbian synaptic plasticity - New perspectives and the need for computational modeling. Neurobiology of Learning & Memory doi: 10.1016/j.nlm.2016.07.023 (IF 3.4) pdf Jedlicka P*, Vlachos A*, Schwarzacher SW, Deller T (2008) A role for the spine apparatus in LTP and spatial learning. Behav Brain Res 192:12-9 pdf Jedlicka P, Backus KH (2005) Inhibitory transmission, activity-dependent ionic changes and neuronal network oscillations. Physiology Research 55:139-149 pdf Jedlicka P (2002) Synaptic plasticity, metaplasticity and BCM theory. Bratisl Med J 103:137-43 pdf * Joint first authors Commentaries, letters to the editorVlachos A, Maggio N, Jedlicka P (2008) Just in time for late-LTP: A mechanism for the role of PKMzeta in long-term memory. Communicative & Integrative Biology, 1:190-1 pdfJedlicka P (2005) Neuroethics, reductionism and dualism. Trends in Cognitive Sciences 9:172 pdf (5-year IF 18.9)Book chapters, conference proceedings
Platschek S, Cuntz H*, Deller T*, Jedlicka P* (2016) Lesion-induced dendritic remodeling as a new mechanism of homeostatic structural plasticity in the adult brain. In: Van Ooyen A, Butz-Ostendorf M (ed), The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain. Elsevier, in press (peer-reviewed) link Mohapatra N, Deans H.T., Santamaria F., Jedlicka P (2014) Modeling ion concentrations. In: Jaeger D, Jung, R (ed), Encyclopedia of Computational Neuroscience, Springer, doi 10.1007/978-1-4614-7320-6_239-2 pdf Jedlicka P (2011) Ist Bewusstsein etwas Neues unter der Sonne? Panpsychismus und Neurowissenschaften. In: Tobias Müller / Heinrich Watzka (Hrsg.), Ein Universum voller ‚Geiststaub’? Der Panpsychismus in der aktuellen Geist-Gehirn-Debatte, Mentis Verlag, Paderborn, pp. 195-222 pdf Jedlicka P (2007) Quantum stochasticity and neuronal computations. Quantum Mind 2007 Conference, Salzburg abstract ppt Jedlicka P (2007) Physical complexity and cognitive evolution In: Gershenson C, Aerts D, Edmonds B (eds), Worldviews, science and us, World Scientific Publishing, Singapore, pp. 221-23 pdf ppt Jedlicka P, Hulin I (2005) Computational models and biology (in Slovak) In: Hulin I (ed), An introduction to scientific research 2, Slovak Academic Press (SAP), Bratislava, pp. 33-41 pdf Jedlicka P, Benuskova L, Macakova J, Ostatnikova D (2002) Molecular Mechanisms of Learning and Memory (in Slovak) In: Hulin I (ed), Pathophysiology, 6th edition, Slovak Academic Press (SAP), Bratislava, pp. 1183-1199 pdf Popular science articlesHow does learning and memory work? Ako funguje učenie a pamäť (in Slovak) .týždeň 06/2014The 2013 Nobel prize for physiology or medicine. Ako išiel mechúrik na vandrovku. (in Slovak) .týždeň 45/2013 časť 1, časť 2The cell, the snowflake, the internet. Bunka, vločka, internet. (in Slovak) .týždeň 15/2005 pdf Electrical synapses. Elektrické synapsy. (in Slovak) .týždeň 5/2005 rtf Laplace's demon. Laplaceov démon. (in Slovak) .týždeň rtf Quantum brain. Kvantový mozog. (in Slovak) Domino fórum 25/2004 rtf Recursive grammar. Rekurzívna gramatika. (in Slovak) Domino fórum 8/2004 rtf Computer in a test-tube. Počítač v skúmavke. (in Slovak) Domino fórum 4/2004 rtf Shape of the universe. O tvare vesmíru. (in Slovak) Domino fórum 45/2003 rtf Small world. Aký je svet malý. (in Slovak) Domino fórum 37/2003 rtf The 2003 Nobel prize for physiology or medicine. Nobelova cena za medicínu 2003. (in Slovak) Domino fórum 52/2003 rtf The character of physical law. Charakter fyzikálnych zákonov. (in Slovak) Spasmus rtf
Popular philosophical and political articles (in Slovak)
Nietzsche, R. I. P. .týždeň pdf Islam and reformation? Islam a reformácia? .týždeň rtf The knight of evolution. Rytier evolúcie. .týždeň pdf Where does liberalism come from? Odkiaľ pochádza liberalizmus? Nie je liberál ako liberál. SME htm Brain, "nothingelsebuttery" and liberal ideals. O mozgu, "ničviacakoizme" a liberálnych ideáloch. SME rtf Truth, tolerance and postmodern thinking. O pravde, tolerancii a postmodernom myslení. prave-spektrum rtf Viktor E. Frankl. Domino fórum rtf Psychology of sexuality. Ochutnávka z psychológie sexuality. rtf Business as a calling. Biznis ako poslanie. Domino fórum rtf Human embryo in the spotlight. Ľudské embryo vo svetle reflektorov. Domino fórum rtf Aristotle and the right to life. O Aristotelovi a práve na život. Domino fórum rtf Karl R. Popper. Domino fórum rtf Galileo Galilei. Domino fórum rtf Reforming Islam. Reformácia islamu. Domino fórum rtf Will medicine provide an answer? Odpovie medicína? SME rtf The free man owns himself. He can damage himself with either eating or drinking; he can ruin himself with gambling. If he does he is certainly a damn fool, and he might possibly be a damned soul; but if he may not, he is not a free man any more than a dog. (Gilbert Keith Chesterton) |