Peter Jedlička, MD, PhD

NeuroScience Center, Clinical Neuroanatomy (Anatomy I)

Johann Wolfgang Goethe-University

Theodor-Stern-Kai 7, D-60590 Frankfurt am Main

Phone: ++49 (69) 6301 6916

Email: jedlicka @ em . uni-frankfurt . de 

Research interests

My long term interest is to better understand how the complex structure of neurons and dynamical intracellular signaling in dendrites and at synapses affect computational properties of the nervous system. My broader, philosophical motivation is to explore whether it is possible to entirely reduce human cognition to neuronal computation. I use approaches that are based on a close interaction between computational modeling and experimental methods.

I am focusing on the following special topics:

* The dentate gyrus is part of the hippocampus which is thought to contribute to mechanisms of learning and memory via activity of dentate granule cells. I am interested in cellular and molecular mechanisms involved in the regulation of dentate network excitability and synaptic plasticity. In my recent work I have contributed to identifying several important molecular players (e.g. neuroligin-2, neuroligin-1 and collybistin) involved in the regulation of dentate physiology (Jedlicka et al. MCN 2009; Winkels, Jedlicka et al. Hippocampus 2009; Jedlicka et al. Cerebral Cortex 2011; Jedlicka, Vnencak et al. Brain Structure & Function 2015).  

* GABAergic inhibitory transmission regulates membrane potential dynamics in neuronal cells thereby crucially controlling excitability in the brain. The efficacy of synaptic inhibition is dynamic and strongly depends on ionic driving force for the chloride-permeable receptors. I want to learn more about general rules that govern spatio-temporal ionic dynamics at inhibitory synapses and their effects on dendritic computation. To address this important issue I have recently created a model of chloride accumulation and diffusion in morphologically realistic dendritic trees (Jedlicka et al. Hippocampus 2011, Mohapatra et al. Sci Reports 2016). The model allowed us to study activity-dependent changes of intracellular chloride concentration and their impact on synaptic inhibition.

* In my neurophilosophical musings, I am fascinated by the quandary
whether scietific exploration of neural mechanisms of mental activity undermines our traditional understanding of personal freedom and responsibilty (Jedlicka TICS 2005)


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Original articles

Mohapatra N , Tønnesen J, Vlachos A , Kuner T , Deller T , Nägerl V , Santamaria F, Jedlicka P (2016) Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition. Scientific Reports, 6:23196. doi: 10.1038/srep23196 (IF 5.6) pdf

Beining M, Jungenitz T, Radic T, Deller T, Cuntz H* , Jedlicka P*, Schwarzacher SWS* (2016) Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells. Brain Structure & Function doi: 10.1007/s00429-016-1285-y (5-year IF 7.5) pdf

Platschek S, Cuntz H, Vuksic M, Deller T*, Jedlicka P* (2016) A general homeostatic principle following lesion induced dendritic remodeling. Acta Neuropathologica Communications, 4:19, doi 10.1186/s40478-016-0285-8 pdf

Jedlicka P, Benuskova L, Abraham WC (2015) A voltage-based STDP rule combined with fast BCM-like metaplasticity accounts for LTP and concurrent “heterosynaptic” LTD in the dentate gyrus in vivo. PLOS Computational Biology, 11:e1004588, Impact Factor 4.6 pdf

O'Sullivan G*, Jedlicka P*, Chen H-X, Kallbouneh H, Ippolito A, Deller T, Nawrotzki R, Kuhse J, Kalaidzidis Y.L., Kirsch J, Schwarzacher SW, Betz H (2016) Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice. Molecular and Cellular Neuroscience, doi: 10.1016/j.mcn.2016.01.010 (IF 3.8) pdf

Jedlicka P*, Vnencak M*, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW (2015) Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo. Brain Structure & Function, 220:47-58 pdf (5-year IF 7.5) 

Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, Müller UC, Deller T*, Jedlicka P* (2015) Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. Journal of Comparative Neurology, 523:1717-1729, (IF 3.2) pdf

Lenz M, Platschek S, Priesemann V, Becker D, Willems LM, Ziemann U, Deller T, Müller-Dahlhaus F, Jedlicka P, Vlachos A (2014) Repetitive magnetic stimulation induces plasticity of excitatory postsynapses on proximal dendrites of cultured mouse CA1 pyramidal neurons. Brain Structure & Function,  220:3323-37 (5-year IF 7.5) pdf

Rawashdeh O, Jilg A, Jedlicka P, Slawska J, Thomas L, Saade A, Schwarzacher SW, Stehle JH (2014) PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus, 24:712-23 pdf (5-year IF 5.1)

Jungenitz T, Radic T, Jedlicka P, Schwarzacher SW (2014) High-frequency stimulation induces gradual immediate early gene expression in maturing adult-generated hippocampal granule cells. Cerebral Cortex24: 1845-1857 ((5-year (IF 8.4) pdf

Becker D, Willems L, Vnencak M, Zahn N, Schuldt G, Jedlicka P, Maggio N, Deller T, Vlachos A (2012) Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhinohippocampal slice cultures. PLoS One 7(11): e48500 pdf (5-year IF 4)

Benuskova L, Jedlicka P  (2012) Computational modelling of long-term depression of synaptic weights: insights from STDP, metaplasticity and spontaneous activity. Neural Network World,  22: 161-180 pdf

Vlachos A, Becker D, Jedlicka P, Winkels R, Roeper J, Deller T (2012) Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures. PLoS One 7(3):e32883 pdf supplement

Jedlicka P, Owen M, Vnencak M, Tschäpe JA, Hick M, Müller UC, Deller T (2012) Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo. Experimental Brain Research 217:441-447 pdf

Jedlicka P, Hoon M, Papadopoulos T, Vlachos A, Winkels R, Poulopoulos A, Betz H, Deller T, Brose N, Varoqueaux F, Schwarzacher SW (2011) Increased Dentate Gyrus Excitability in Neuroligin-2-Deficient Mice in Vivo. Cerebral Cortex, 21:357-367 pdf supplement
Jedlicka P, Deller T, Gutkin B, Backus KH (2011) Activity-dependent intracellular chloride accumulation and diffusion controls GABAA receptor-mediated synaptic transmission. Hippocampus, 21:885-98 pdf

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J,
29(14):2421-32. pdf, supplement

Jedlicka P, Deller, T, Schwarzacher SW (2010) Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus. Journal of Computational Neuroscience, 29:509–519 pdf

Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron, 63:628-42 pdf

Jedlicka P, Papadopoulos T, Deller T, Betz H, Schwarzacher SW (2009) Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Molecular and Cellular Neuroscience, 41:94-100 pdf

Winkels R*, Jedlicka P*, Weise F, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of ßIV-spectrin mutant mice in vivo. Hippocampus, 19:677-86 pdf

Jedlicka P*, Schwarzacher SW*, Winkels R, Kienzler F, Bramham CR, Frotscher M, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst LTP and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus, 19:130-140 pdf

Kienzler F, Jedlicka P, Vuksic M, Deller T, Schwarzacher SW (2006) Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse. Brain Res 1085(1):195-8 pdf

Review articles

Jedlicka P, Deller T (2016) Understanding the role of synaptopodin and the spine apparatus in Hebbian synaptic plasticity - New perspectives and the need for computational modeling. Neurobiology of Learning & Memory doi: 10.1016/j.nlm.2016.07.023 (IF 3.4) pdf

Jedlicka P*, Vlachos A*, Schwarzacher SW, Deller T (2008) A role for the spine apparatus in LTP and spatial learning. Behav Brain Res 192:12-9 pdf

Jedlicka P, Backus KH (2005) Inhibitory transmission, activity-dependent ionic changes and neuronal network oscillations. Physiology Research 55:139-149 pdf

Jedlicka P (2002) Synaptic plasticity, metaplasticity and BCM theory. Bratisl Med J 103:137-43 pdf

* Joint first authors

Commentaries, letters to the editor

Vlachos A, Maggio N, Jedlicka P (2008) Just in time for late-LTP: A mechanism for the role of PKMzeta in long-term memory. Communicative & Integrative Biology, 1:190-1 pdf

Jedlicka P (2005) Neuroethics, reductionism and dualism. Trends in Cognitive Sciences 9:172 pdf (5-year IF 18.9) 

Book chapters, conference proceedings

Platschek S, Cuntz H*, Deller T*, Jedlicka P* (2016) Lesion-induced dendritic remodeling as a new mechanism of homeostatic structural plasticity in the adult brain. In: Van Ooyen A, Butz-Ostendorf M (ed), The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain. Elsevier, in press (peer-reviewed) link

Mohapatra N, Deans H.T., Santamaria F., Jedlicka P (2014) Modeling ion concentrations. In: Jaeger D, Jung, R (ed), Encyclopedia of Computational Neuroscience, Springer, doi 10.1007/978-1-4614-7320-6_239-2 pdf

Jedlicka P (2011) Ist Bewusstsein etwas Neues unter der Sonne? Panpsychismus und Neurowissenschaften. In: Tobias Müller / Heinrich Watzka (Hrsg.), Ein Universum voller ‚Geiststaub’? Der Panpsychismus in der aktuellen Geist-Gehirn-Debatte, Mentis Verlag, Paderborn, pp. 195-222 pdf

Jedlicka P (2007) Quantum stochasticity and neuronal computations. Quantum Mind 2007 Conference, Salzburg  abstract ppt   

Jedlicka P (2007) Physical complexity and cognitive evolution In: Gershenson C, Aerts D, Edmonds B (eds), Worldviews, science and us, World Scientific Publishing, Singapore, pp. 221-23 pdf  ppt

Jedlicka P, Hulin I (2005) Computational models and biology (in Slovak) In: Hulin I (ed), An introduction to scientific research 2, Slovak Academic Press (SAP), Bratislava, pp. 33-41 pdf

Jedlicka P, Benuskova L, Macakova J, Ostatnikova D (2002) Molecular Mechanisms of Learning and Memory (in Slovak) In: Hulin I (ed), Pathophysiology, 6th edition, Slovak Academic Press (SAP), Bratislava, pp. 1183-1199 pdf

Popular science articles

How does learning and memory work? Ako funguje učenie a pamäť (in Slovak) .týždeň 06/2014

The 2013 Nobel prize for physiology or medicine. Ako išiel mechúrik na vandrovku. (in Slovak) .týždeň 45/2013 časť 1, časť 2

The cell, the snowflake, the internet. Bunka, vločka, internet. (in Slovak) .týždeň 15/2005 pdf

Electrical synapses. Elektrické synapsy. (in Slovak) .týždeň 5/2005 rtf

Laplace's demon. Laplaceov démon. (in Slovak) .týždeň rtf

Quantum brain. Kvantový mozog. (in Slovak) Domino fórum 25/2004 rtf 

Recursive grammar. Rekurzívna gramatika. (in Slovak) Domino fórum 8/2004 rtf 

Computer in a test-tube. Počítač v skúmavke. (in Slovak) Domino fórum 4/2004 rtf 

Shape of the universe. O tvare vesmíru. (in Slovak) Domino fórum 45/2003 rtf

Small world. Aký je svet malý. (in Slovak) Domino fórum 37/2003 rtf 

The 2003 Nobel prize for physiology or medicine. Nobelova cena za medicínu 2003. (in Slovak) Domino fórum 52/2003 rtf 

The character of physical law. Charakter fyzikálnych zákonov. (in Slovak) Spasmus rtf 


Popular philosophical and political articles (in Slovak)

Nietzsche, R. I. P. .týždeň pdf

Islam and reformation? Islam a reformácia? .týždeň rtf

The knight of evolution. Rytier evolúcie. .týždeň pdf

Where does liberalism come from? Odkiaľ pochádza liberalizmus? Nie je liberál ako liberál. SME htm

Brain, "nothingelsebuttery" and liberal ideals. O mozgu, "ničviacakoizme" a liberálnych ideáloch.  SME  rtf

Truth, tolerance and postmodern thinking. O pravde, tolerancii a postmodernom myslení. prave-spektrum rtf

Viktor E. Frankl. Domino fórum rtf

Psychology of sexuality. Ochutnávka z psychológie sexuality. rtf 

Business as a calling. Biznis ako poslanie. Domino fórum rtf 

Human embryo in the spotlight. Ľudské embryo vo svetle reflektorov. Domino fórum rtf 

Aristotle and the right to life. O Aristotelovi a práve na život. Domino fórum rtf

Karl R. Popper. Domino fórum rtf 

Galileo Galilei. Domino fórum rtf 

Reforming Islam. Reformácia islamu. Domino fórum rtf 

Will medicine provide an answer? Odpovie medicína? SME rtf

The free man owns himself. He can damage himself with either eating or drinking; he can ruin himself with gambling. If he does he is certainly a damn fool, and he might possibly be a damned soul; but if he may not, he is not a free man any more than a dog. (Gilbert Keith Chesterton)