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Welcome to the Park Lab
Center for Functional Connectomics, Korea Institute of Science and Technology
 
Communication between neuronal cells through their synapses conveys information, generates neural circuit activity, and ultimately gives rise to behavior.
Structural changes of neural circuits, characterized by synapse formation and elimination, underlie developmental plasticity as well as learning and memory.
We are interested in understanding how neural circuits are developed and remodeled at the level of synapses.
For this, we utilize state-of-the-art imaging technology to capture the dynamic regulation of synapses at cellular and molecular levels.
We also employ genetically modified animal models such as C. elegans and mouse to investigate the mechanisms underlying synapse function.         
 
                                    

                               
 Photoactivatible GFP (paGFP): imaging dynamics of synaptic molecules with high temporal and spatial resolution

Local photoactivation by mosaic module ‎‎‎‎‎‎‎‎‎‎(spine vs dendritic shaft)‎‎‎‎‎

                                                                                                                                                                                                      
                                                                                                                                                                                   
                  
                                                                                                                                                                                                                                                                                                                                                                                                                                           













  ¨  Congratulations on I-Seul's paper published in PLoS ONE!!!   (Feb 27, 2017)
      


  ¨  Congratulations on Jung-Hwa's paper published in Frontiers in Synaptic Neuroscience!!!   (June 29, 2016)
      


  ¨  Congratulations on Eunsil's paper published in Pharmacological Research!!!   [Epub ahead of print] (June 9, 2016)
                 
   


  ¨  Eunsil's paper (Cho et al., 2015) was selected as an excellent paper and was poster-presented in 2015 UST Conference.
       (Nov 5, 2015)       



  ¨  Eunsil was a winner for pre-doctoral awards at the Association of Korean Neuroscientists (AKN), Society for Neuroscience (SfN) held in Chicago.  
        Congratulations!!!    (Oct 19, 2015)       

                          
   

 


  ¨  Congratulations on Eunsil's paper published in Scientific Reports!!!   (July 29, 2015)
       
          
     





















Overexpression of CCNY inhibits glycine-induced increase of SEP-GluA1 fluorescence in the spine

Knockdown of CCNY facilitates glycine-induced increase of SEP-GluA1 fluorescence in the spine