Although Parkinson's disease [PD] itself works on smooth primarily, and not cardiac muscle, Parkinson's disease can affect the heart, just as well as the cardiovascular system can affect Parkinson's disease. Not only is PD a disease of inflammation, but it can also affect [harden] the arteries which are smooth muscle. Symptoms of the disease produced by hardening of the arteries will naturally depend upon which arteries are most severely affected. Therefore, If the heart arteries begin to harden, the heart muscle will be deprived of its normal body supply, and heart disease will be the inevitable result. Further, if the arteries of the legs are primarily affected, and if remedial measures are not effective, circulation in the legs is impaired. If, on the other hand, the hardening process occurs in the brain, various brain diseases will result. Studies show that if hardening of the arteries occurs in the area of the brain, known as the basal ganglia [the "governor of steadiness"], is situated, typical symptoms of PD will occur.
Blood Vessel Abnormalities:
Blood vessel abnormalities in the brain could very possibly be a factor in the cause of Parkinson's disease in some patients, though it is treatable.