Effects on Circulatory System

Cardiac Effects: 
Although Parkinson's disease [PD] itself works on smooth primarily, and not cardiac muscle, Parkinson's disease can affect the heart, just as well as the cardiovascular system can affect Parkinson's disease. Not only is PD a disease of inflammation, but it can also affect [harden] the arteries which are smooth muscle. Symptoms of the disease produced by hardening of the arteries will naturally depend upon which arteries are most severely affected. Therefore, If the heart arteries begin to harden, the heart muscle will be deprived of its normal body supply, and heart disease will be the inevitable result. Further, if the arteries of the legs are primarily affected, and if remedial measures are not effective, circulation in the legs is impaired. If, on the other hand, the hardening process occurs in the brain, various brain diseases will result. Studies show that if hardening of the arteries occurs in the area of the brain, known as the basal ganglia [the "governor of steadiness"], is situated, typical symptoms of PD will occur. 

Blood Vessel Abnormalities: 
Blood vessel abnormalities in the brain could very possibly be a factor in the cause of Parkinson's disease in some patients, though it is treatable. 
Peter Jannetta, MD, developed the modern surgical technique to treat this condition called, microvascular decompression (MVD). Curing this abnormality consists of repositioning compressive arteries in the brain and placing a protective pad between the artery and the structure it is compromising. Dr. Jannetta discovered that by "decompressing a patient's cerebral penduncle by mobilizing and reposition the offending artery", he could find a cure to their particular case regarding Parkinson's Disease. Dr Jannetta explained, "Though we clearly need to continue our research on a larger scale to substantiate this remarkable observation, the very idea that a manageable vascular abnormality in the brain may be a critical factor in disease onset and manifestation for some Parkinson's patients is an extremely exciting possibility".