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O2 SM & ASVD : O2 Refs 151005 - 1407

Come back to:  638<742  

    1. W. Dock, Ann. Int. Med. 49: 699-705, 1958. "Research in Arteriosclerosis The-First 50 Years"

    2. N.N. Kipshidge, Bull. Exp. Biol. Med. 47: 447-53, 1959. "The Effect of Oxygen-Deficiency on the Development of Experimental Atherosclerosis of the Coronary Arteries"   * 

    3. K. Kjeldsen, J. Atherosclerosis Res. 10: 173-8, 1969. "Reversal of Rabbit Atheromtosis by Hyperoxia"  * 
    4. P. Astrup, Atherosclerosis: Proceedings of the Second International Symposium: 108-11;1970:--"The Effects of Exposure to Carbon Monoxide; Hypoxia and Hyperoxia on the Development of Experimental Atheromatosis in Rabbits"   * 

    5. S.A. Kumar, "Oxygen Uptake and Release by Red Cells
through Capillary Wall and Plasma Layer" (PhD thesis) 1969. 

    6. R.M. Navari, Blood Oxygenation: 243-61, 1970. "Effect of Plasma Constituents on Oxygen Diffusivity" 

    7. T.K. Goldstick, Mass Transfer in Biological Systems: 101-
13, 1970. "Diffusion of Oxygen in Solutions of Blood Proteins"

    8. Dixon 1958, "Fatty Deposition: A Disorder of the Cell", Quart. J. Exp. Physiol. 43: 139-59.

 9. Spain 1962, ""Rabbit Local Tissue Response to Triglycerides, Cholesterol and Its Ester",  Arch. Path. 73: 82. 

10. Adams 1963, "Phospholipids in atherosclerosis: the modification of the cholesterol granuloma by phospholipid", J. Pathology & Bacteriology, 86: 431.   * 

11. Buck 1951, "Lipids of normal and atherosclerotic aortas", Arch. Path., 51: 224. 

12. Adams 1964, "Arteriosclerosis in Man, Other Mammals and Birds", BioI. Rev. 39: 372. 

13. Shore 1955 "Plasma Phospholipide Deposition and Aortic Phospholipide Synthesis in Experimental Atherosclerosis", Am. J. Physiol., 181: 527.  * 

14. ZilversmIt 1954, "The Origin of Aortic Phospholipid in Rabbit Atheromatosis", Circulation, 9: 581-5.  * 

15. McCandless 1956, "The Effect of Cholesterol on the Turnover of Lecithin, Cephalin and Sphingomyelin in the Rabbit", Arch. Biochem. Biophys., 62: 402. 

16. Adams 1963, "Histochemical observations on the localization and origin of sphingomyelin, cerebroside, and cholesterol in the normal and atherosclerotic human artery". J. Pathology & Bacteriology, 85: 113.  * 

17. Adams 1963: "The distribution of lipids and enzymes in the aortic wall in dietary rabbit atheroma and human atherosclerosis", J. Pathology & Bacteriology, 86: 42   

18. Friedkin-1948, "Oxidatlon-Coupled Incorporation of Inorgainc Radiophosphate into Phospholipid and Nucleic Acid in a Cell Free System", J. BioI. Chem. 177: 775.  * 

19. Chaikoff 1942, "The Application of Labeling Agents to the Study of Phospholipid Metabolism", Physiol. Rev. 22:  291. 

20. Adams 1962, "A Hypothesis to Explain the Accumulation of Cholesterol in Atherosclerosis", Lancet 1: 890.    * 

21. Heppner 2004,"Plasma Oxygen Permeability May be a Factor in Atherosclerosis",J Atheroscler. Thromb. 11<  * 

Searching PubMed for "hypoxia atherogenesis" yield 742 references:

742<742    1959 
[Effect of anoxia on the development of experimental coronary atherosclerosis].     http://www.ncbi.nlm.nih.gov/pubmed/13651309   
   In Russian.  No abstract. 

736<742    1969 
Effects of hypoxia and of carbon monoxide exposures on experimental atherosclerosis   
    No Abstract. 
    181 Related citations:   
    2 Cited by's. 

727<742    1972  * 
Plasma proteins, oxygen transport and atherosclerosis   
    No Abstract.  Gainer & Chisolm et al. 
    104 Related citations

724<742    1974  * 
Oxygen diffusion and atherosclerosis   
    No Abstract.    Gainer & Chisolm 
    1 Cited by. 

717<742    1975 
Effects of intermittent and continuous hypoxia on the aortic wall in rabbits.   
http://www.ncbi.nlm.nih.gov/pubmed/125091    Helin
    2 Cited by's. 

706<742    1977    *
Oxygen, the arterial, wall, and atherosclerosis.    
    No Abstract.    Jurris & Weiss
    141 Related citations

699<742    1978 
Carbon monoxide-induced arterial wall hypoxia and atherosclerosis.   
    112 Related citations

682<742    1983 
Some pathogenetic factors of age-related specificities in experimental atherosclerosis   
a) by insufficient synthesis of phospholipids in aortic tissue; ... d) growing difficulties in ensuring oxygen supply to the organism"  
    187 Related citations

681<742    1983 
Serum lipemia: an overlooked cause of tissue hypoxia.   
... serum lipemia affects the transfer of oxygen from the blood to the tissues. ... The contribution of hypoxia of the arterial wall to atherogenesis is outlined, and its adverse effects in the ischemic heart are listed."  
    1 Cited by. 

678<742    1983 
The effect of oxygen on the development of atherosclerosis in WHHL rabbits.   
From these results, we conclude that hyperoxic or hypoxic inhalation respectively regresses or aggravates the development of atherosclerotic lesions, not by an indirect action on blood lipid concentrations but by a direct action on the vascular wall."  
    2 Cited by's. 

Effect of hypoxia on cholesterol accumulation in cultured rabbit aortic smooth muscle cells.   
    103 Related citations

668<742    1985  * 
Mechanisms of atherogenesis: endothelial hypoxia proposed as the major initiator.    
A common factor of blood vessel hypoxia, specifically endothelial and intimal hypoxia, is shown to exist."     Boxen 
    1 Cited by. 

664<742    1987  * 
[The role of carotenoids in the development of compensatory reactions of the body to hypoxia]   
http://www.ncbi.nlm.nih.gov/pubmed/3825387   in Russian.  
    93 Related citations

658<742    1987  *  
Hypoxia and atherosclerosis: re-evaluation of an old hypothesis.   
    3 Cited by's. 

647<742    1989    * 
Endothelial hypoxia induction of atherosclerosis: an explanation of patency rates for internal mammary artery and other coronary artery bypass grafts.   
http://www.ncbi.nlm.nih.gov/pubmed/2689844    Boxen again

638<742    1991  **
Arterial wall oxygenation, oxyradicals, and atherosclerosis.   
    My comment
This is the first, and therefore the oldest, reference found in this search mentioning "oxyradicals".   
    Searching PubMed for "oxygen free radicals atherosclerosis" found 2240 references. 
It was dated 1982:   16 search references to here. 

610<742    1996  * 
Non-ischemic hypoxia of the arterial wall is a primary cause of atherosclerosis       
    2 Cited by's. 

591<742    1998 
Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas   
    My comment
This is the first, and therefore the oldest, reference to mention oxidized lipoproteins. 

584<742    1999   
Evidence of hypoxic areas within the arterial wall in vivo.    
    Free Final Version:   

534<742 2003
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms.
    My comment:   
Another oxLDL reference. 

527<742    2003 
Nocturnal oxygen desaturation correlates with the severity of coronary atherosclerosis in coronary artery disease.  

520<742    2004 
Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia   
    Oxidative stress. 

512<742    2004 
Plasma oxygen permeability may be a factor in atherosclerosis.    
    My paper. 

Oxidative stress and hypoxia: implications for plasminogen activator inhibitor-1 expression   
    More O2 stress. 

504<742    2004 
Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages.   

    More oxLDL. 

503<742    2005 
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology.  
    More oxLDL. 

495<742    2005 
Repetitive hypoxia increases lipid loading in human macrophages-a potentially atherogenic effect   

488<742   2005 

Sleep-apnea-related intermittent hypoxia and atherogenesis: adhesion molecules and monocytes/endothelial cells interactions.

484<742    2006 

Statins inhibit hypoxia-induced endothelial proliferation by preventing calcium-induced ROS formation.
    Both hypoxia & ROS. 

454<744    2007 
Sleep apnoea inducing hypoxemia is associated with early signs of carotid atherosclerosis in males   

443<744    2007 
Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia   
    Hypoxia causing oxLDL.  

435<744    2007 
Chronic intermittent hypoxia induces atherosclerosis   

408<744    2008 
Intermittent hypoxia: the culprit of oxidative stress, vascular inflammation and dyslipidemia in obstructive sleep apnea.   
(Click on "Clinical Key") 

326<744    2009 
The role of hypoxia in atherosclerosis.   

226<744    2011 
Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication.   
    3 Cited by's   
    Free full text

130<744    2013 
Hypoxia in atherosclerosis and inflammation.   

86<744    2014 
Cardiovascular complications of sleep apnea: role of oxidative stress   
    Free PMC Article: 

31<744    2015 
Potential contributions of intimal and plaque hypoxia to atherosclerosis   

Searching PubMed for "sphingomyelin oxygen atherogenesis " revealed only 15 references, none of which were helpful. 


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