Micro-/Nanofluidics + Electrokinetics = Bio-sensor
for (bio-)molecule Detection, Separation and Concentration
- This device makes it possible
to selectively extract target molecules such as streptavidin and bovine
serum albumin and then highly concentrate them up to higher than 5
orders of magnitude from a complex mixture of analytes ranging from 1 nM
to 10 fM.
Nanofluidic and Electrokinetic Flow Phenomena
- Experimental Investigation of Flow Instability,
Circulation and Vortex in the presence of Electric fields.
- Theoretical and Numerical Approach using CFD to
confirm Experimental Results.
- Applications of the Phenomena to microfluidic Pump
studies and mechanistic modeling on the
responses of cells and proteins to external mechanical and electrical
- The movie below shows that microtubules ( one of
cytoskeleton filaments) on a kinesin (biomolecular motor)-coated surface
are aligned with an electric field due to electrophoretic forces.
- Also, the traslocation of a
single microtubule by kinesin is guided to move
along a circle by manipulating the direction and strength of electric