Evolution and Cancer laboratory - Trevor A Graham

Our EPICC project, in collaboration with Andrea Sottoriva's lab at the ICR, with use a combination of multi-omic measurement and mathematical modelling to forecast colorectal cancer evolution.

Circos plot of copy-number alterations in a colon cancer.
Each ring represents the copy-number alterations in a different
region of the tumour. 

We are a multi-disciplinary Evolution and Cancer laboratory at the Barts Cancer Institute, part of QMUL in London, UK.  Our hope is that understanding how tumours evolve will lead to the development of better biomarkers and optimised therapeutic strategies for cancer patients.  

Our lab consists of an inter-disciplinary team of mathematicians, computer scientists, evolutionary biologists, cancer biologists, and clinicians who work closely together to understand how cancer evolves and to translate our findings into the clinic.  If you're interested in evolution and cancer, get in touch about opportunities to work with us.

Our lab is focused on how the processes of mutation and clonal expansion determine patterns of tumour occurrence and progression.  We attempt to reconstruct and understand the life-history of tumours; in particular by measuring the timing and rate of mutations to understand how, when and why a mutant clone grows.  We are also looking at how to intervene in cancer evolution for therapeutic benefit, and how to measure evolution in a clinically-relevant way.  We are also interested in understanding the phenotypes histological processes that drive clonal expansions in the body.

We utilise a combination of molecular techniques, phylogenetic analyses, mathematical and computational modelling and evolutionary biology theory.

Phylogenetic tree derived from multi-region whole genome sequencing
of a colon cancer. Numbers denote mutation burden on each branch in the tree.