Mailing Address                        
Cell Biology
Program
Research Institute
The Hospital for Sick Children
686 Bay Street, PGCRL
Lab Room 19.9410, Bench J West
Toronto, Ontario M5G 0A4

CANADA



 
Phone                                       
(416) 813-6612
(416) 813-5028 (Fax)


  E-mail                                       

n.pillon@gmail.com


    


 

   Nicolas J. PILLON

        Date of Birth: March 20, 1983
        Nationality: French

   Current Position: Post-doctoral Research Fellow

        Program in Cell Biology, The Hospital for Sick Children
        University of Toronto
        Supervisor: Dr. Amira Klip

   Keywords

        Metabolic diseases, Diabetes, Obesity
        Inflammation

        Insulin, signal transduction
        Skeletal muscle


   Research Interests
        
Association of obesity with high blood pressure, insulin resistance and/or high circulating fats is a leading cause of type 2 diabetes and cardiovascular diseases. This cluster of risk factors, defined as the “metabolic syndrome”, is now considered a health epidemic and economic burden of unmanageable proportions. Insulin resistance is a central problem in the metabolic syndrome and I and others have demonstrated that it can be induced in vitro by either the damaging effects of saturated fatty acids, oxidants or inflammatory cytokines; however, the situation in vivo is far more complex and needs further investigation, as no efficient therapeutic strategies are currently available for the treatment of type 2 diabetes. In this context, I am focused on understanding how insulin action can be impaired by excess fatty acids, oxidative stress and inflammation, from both cell biology and more global physiological perspectives.
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Nicolas PILLON,
Jul 10, 2013, 9:28 AM