Nicolas J. PILLON

        Date of Birth: March 20, 1983
        Nationality: French

   Current Position: Post-doctoral Researcher

        Department of Physiology and Pharmacology (FYFA)
        Karolinska Institutet
        Mentors: Prof. Juleen Zierath and Prof Anna Krook

   Keywords

        Metabolic diseases, Diabetes, Obesity
        Inflammation

        Insulin, signal transduction
        Skeletal muscle


   Research Interests
        
Association of obesity with high blood pressure, insulin resistance and/or high circulating fats is a leading cause of type 2 diabetes and cardiovascular diseases. This cluster of risk factors, defined as the “metabolic syndrome”, is now considered a health epidemic and economic burden of unmanageable proportions. Insulin resistance is a central problem in the metabolic syndrome and I and others have demonstrated that it can be induced in vitro by either the damaging effects of saturated fatty acids, oxidants or inflammatory cytokines; however, the situation in vivo is far more complex and needs further investigation, as no efficient therapeutic strategies are currently available for the treatment of type 2 diabetes. In this context, I am focused on understanding how insulin action can be impaired by excess fatty acids, oxidative stress and inflammation, from both cell biology and more global physiological perspectives.
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Nicolas PILLON,
Oct 3, 2014, 6:04 AM