SCIENTIFIC PROGRAM




10th International Meeting
STEROIDS and NERVOUS SYSTEM



FEBRUARY 16   9-17 Satellite Symposium



FEBRUARY 16 - Meeting

14-17 Registration (Anatomy, Torino)


17.30 - Opening Ceremony



18.00   OPENING LECTURE

G. Ball  (USA)

Pleiotropic effects of testosterone: lessons from studies of the avian song system

19.00 Welcome cocktail


FEBRUARY 17


SYMPOSIUM - Aromatase in the female brain - Why produce locally when available globally?


9.00 C.A. Cornil (Belgium): Neuroestrogens and female sexual behavior 

9.30 C. de Bournonville (USA): Steroid synthesis in the auditory forebrain of female zebra finches in response to song

10.00 K.M. Frick (USA): The role of hippocampal estradiol synthesis in regulating memory formation

10.30 J.D. Blaustein (USA): Aromatase inhibitors in postmenopausal women with breast cancer: a possible role for neuroestrogens?

11.00-11.30 – Coffee break

11.30-12.00  Free oral communications


12.15-13.00 PLENARY LECTURE

I. Torres Aleman (Spain)

The blood-brain-barrier and the cross-talk of estradiol and IGF-1 in mood regulation


13.00-14.00 Lunch and Poster exhibition



SYMPOSIUM - Sex differences in fear and stress responses: relevance to disease vulnerability and treatment for psychopathology


14.00 D. Bangasser (USA): Sex differences in stress regulation and cognition

14.30 C. Dalla (Greece): Sex differences in psychopharmacology: from estrogens to neuroestrogens in models of depression

15.00 M. Milad (USA): Neural mechanisms of fear extinction in her and his brains: implications to treatment and psychopathology of fear disorders

15.30 – 16.00 Coffee Break


SYMPOSIUM Prevention of behavioral disorders caused by stress-induced disruption of steroid pathways in pregnancy and in the early postnatal period.


16.00 P. Brunton (UK): Effects of prenatal stress on neurosteroid pathways in the offsprings

16.30 S. Matthews (Canada): Glucocorticoid Programming of the Fetal Brain: Intergenerational Consequences

17.00 J. Hirst (Australia): Loss of neurosteroid support contributes to adverse long term behavioural outcomes following preterm birth



17.30-18.30 Round table The problem with sex differences

L. Galea (USA): Mandating the study of sex differences will NOT improve women’s health

F. Sohrabji (USA): Breast cancer, cardiovascular disease and the brain: When hormone experts don’t talk to each other.

E. Choleris (USA): Underpowered research on sex differences and sex-specific analyses

M. McCarthy (USA): Sex as a biological variable: lack of understanding and appreciation by grant reviewers and applicants

 


FEBRUARY 18


SYMPOSIUM - Molecular mechanisms of glucocorticoid effects


9.00 D.B. De Franco (USA): Crosstalk between the endocannabinoid and glucocorticoid signaling pathways in the developing brain

9.30 M.J. Garabedian (USA): Regulation of glucocorticoid receptor phosphorylation and genomic action by brain-derived neurotrophic factor in cortical neurons

10.00 H. Krugers (The Netherlands): Effects of early life stress: partial reversal

10.30 R. Hunter (USA): Glucocorticoid receptor modulation of hippocampal chromatin

 

10.30-11.00 – Coffee break


11.30-12.00  Free oral communications



12.15-13.00 PLENARY LECTURE

C. Pariante (UK)

Glucocorticoids, inflammation and psychiatric illness



13.00-14.00 Lunch and Poster exhibition

 


SYMPOSIUM Countering neuroactive steroids: a novel therapeutic avenue in neuropsychiatry?


14.00 T. Di Paolo (Canada): Effects of 5alpha-reductase inhibitors in the brain and gut of MPTP mouse model of Parkinson’s disease

14.30 R. Frau (Italy): Blocking neurosteroidogenesis as a novel tool for the cognitive complications of sleep disorders

15.00 M. Bortolato (USA): Inhibition of neurosteroidogenesis as a therapy for impulse-control problems and substance use disorders


15.30-16.00 Coffee break


SYMPOSIUM Toward a sex dimorphic neurology


16.00 W.A. Rocca (USA): Sex, gender and Parkinson’s disease

16.20 M.M. Mielke (USA): Sex, gender and dementia

16.40 K. Kantarci (USA): Hormone therapy and dementia risk in women

17.00 V.M. Miller (USA): Sex, gender, hormones and neurovascular aging



FEBRUARY 19

SYMPOSIUM - Sex differences and effects of neuroactive steroids on brain mitochondrial function and metabolism


9.00 M. Astiz (Germany): Developmental sex differences in the metabolism of cardiolipin in mouse cerebral cortex mitochondria

9.30 J.A. Chowen (Spain): Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes

10.00 G.E. Barreto (Colombia): Tibolone reduces oxidative damage and inflammation in microglia stimulated with palmitic acid through mechanisms involving estrogen receptor beta

10.30 A. Eckert (Switzerland): Effects of sex hormones on mitochondrial activity and bioenergetics – implications for Alzheimer’s disease

11.00-11.30 Coffee break

11.30-12.00  Free oral communications



12.15-13.00 SPECIAL LECTURE

N. Shah (USA)

Contextual control of innate social behaviors



 

13.00-15.00 Lunch and POSTER DISCUSSION



SYMPOSIUM Multi-faceted functions of estrogens in the ventromedial hypothalamic nucleus


15.00 Y. Xu (USA): An estrogen-responsive neural network: start from the ventromedial hypothalamic nucleus

15.30 M. López (Spain): Complex lipid metabolism within the VMH mediates the central actions of estradiol on energy balance

16.00 V. Routh (USA): Estrogen regulation of ventromedial hypothalamus glucose-inhibited neurons may play a role in glucose homeostasis

16.30 D. Lin (USA): The Esr1+ cells in ventromedial hypothalamus as an essential population for male and female aggression



21.00 SOCIAL DINNER


FEBRUARY 20


SYMPOSIUM - Molecular tools unleashed for the study of neuroactive steroid synthesis and action


9.00 L. Remage-Healey (USA): Viral targeting of neuronal subtypes to dissect rapid neurosteroid regulation of sensory cortex

9.30 S. Moenter (USA): Estradiol feedback on the reproductive neuroendocrine system

10.00 I. Abraham (Hungary): Super-resolution imaging of rapid estradiol effects on surface movement of glutamate receptors in live neurons

10.30 T. Stincic (USA): Optogenetics and calcium imaging reveal novel actions of estrogenic signaling on hypothalamic circuits that regulate energy balance

 

11.00-11.30 Coffee break


11.45-12.30 PLENARY LECTURE

V. Prevot (France)

Hypothalamic circuits of reproduction and steroid hormones


12.30-13.30 Lunch


13.30-14.30 YOUNG INVESTIGATORS Symposium



SYMPOSIUM - Vitamin D and brain


14.30 M. Norlin (Sweeden): Vitamin D and the brain  - potential effects on steroidogenesis in the nervous system and possible role in the treatment of brain cancer

15.00 G.F. Jirikowski (Germany): Binding globulin for Vitamin D and localization in the nervous system

15.30 X. Cui (Australia): Vitamin D modulates dopamine development via its genetic and epigenetic actions

16.00-16.30 Coffee break


SYMPOSIUM - The impact of endocrine disrupting chemicals (EDCs) interfering with steroid signaling on neurodevelopment


16.30 E. Rissman (USA): Transgenerational actions of endocrine disrupting compounds on genes and behavior

17.00 W. Lichtensteiger (Switzerland): Genes controlling developmental processes in hippocampus as targets of behaviorally active chemicals: possible microRNA involvement

17.30 A. Parent (Belgium): Neuroendocrine disruption of puberty and reproduction

 


CLOSURE OF THE MEETING