SCIENTIFIC PROGRAM




10th International Meeting
STEROIDS and NERVOUS SYSTEM



FEBRUARY 16   9-17 Satellite Symposium



FEBRUARY 16 - Meeting

14-17 Registration (Anatomy, Torino)


17.30 - Opening Ceremony



18.00   OPENING LECTURE

G. Ball  (USA)

Pleiotropic effects of testosterone: lessons from studies of the avian song system

19.00 Welcome cocktail


FEBRUARY 17


SYMPOSIUM - Aromatase in the female brain - Why produce locally when available globally?


9.00 C.A. Cornil (Belgium): Neuroestrogens and female sexual behavior 

9.30 C. de Bournonville (USA) Steroid synthesis in the auditory forebrain of female zebra finches in response to song

10.00 K.M. Frick (USA) The role of hippocampal estradiol synthesis in regulating memory formation

10.30 J.D. Blaustein (USA): Aromatase inhibitors in postmenopausal women with breast cancer: a possible role for neuroestrogens?

11.00-11.30 – Coffee break

11.30-12.00  Free oral communications


12.15-13.00 PLENARY LECTURE

I. Torres Aleman (Spain)

The blood-brain-barrier and the cross-talk of estradiol and IGF-1 in mood regulation


13.00-14.00 Lunch and Poster exhibition



SYMPOSIUM - Sex differences in fear and stress responses: relevance to disease vulnerability and treatment for psychopathology


14.00 D. Bangasser (USA): Sex differences in stress regulation and cognition

14.30 C. Dalla (Greece): Sex differences in psychopharmacology: from estrogens to neuroestrogens in models of depression

15.00 M. Milad (USA): Neural mechanisms of fear extinction in her and his brains: implications to treatment and psychopathology of fear disorders

15.30 – 16.00 Coffee Break


SYMPOSIUM Prevention of behavioral disorders caused by stress-induced disruption of steroid pathways in pregnancy and in the early postnatal period.


16.00 P. Brunton (UK): Effects of prenatal stress on neurosteroid pathways in the offsprings

16.30 S. Matthews (Canada): Glucocorticoid Programming of the Fetal Brain: Intergenerational Consequences

17.00 J. Hirst (Australia): Loss of neurosteroid support contributes to adverse long term behavioural outcomes following preterm birth



17.30-18.30 Round table  The problem with sex differences

L. Galea (Canada): Mandating the study of sex differences will NOT improve women’s health

F. Sohrabji (USA): Breast cancer, cardiovascular disease and the brain: When hormone experts don’t talk to each other.

E. Choleris (Canada): Underpowered research on sex differences and sex-specific analyses

M. McCarthy (USA): Sex as a biological variable: lack of understanding and appreciation by grant reviewers and applicants

 


FEBRUARY 18


SYMPOSIUM - Molecular mechanisms of glucocorticoid effects


9.00 D.B. De Franco (USA): Crosstalk between the endocannabinoid and glucocorticoid signaling pathways in the developing brain

9.30 M.J. Garabedian (USA): Regulation of glucocorticoid receptor phosphorylation and genomic action by brain-derived neurotrophic factor in cortical neurons

10.00 H. Krugers (The Netherlands): Effects of early life stress: partial reversal

10.30 R. Hunter (USA): Glucocorticoid receptor modulation of hippocampal chromatin

 

10.30-11.00 – Coffee break


11.30-12.00  Free oral communications



12.15-13.00 PLENARY LECTURE

C. Pariante (UK)

Glucocorticoids, inflammation and psychiatric illness



13.00-14.00 Lunch and Poster exhibition

 


SYMPOSIUM Countering neuroactive steroids: a novel therapeutic avenue in neuropsychiatry?


14.00 T. di Paolo (Canada): Effects of 5alpha-reductase inhibitors in the brain and gut of MPTP mouse model of Parkinson’s disease

14.30 R. Frau (Italy): Blocking neurosteroidogenesis as a novel tool for the cognitive complications of sleep disorders

15.00 M. Bortolato (USA): Inhibition of neurosteroidogenesis as a therapy for impulse-control problems and substance use disorders


15.30-16.00 Coffee break


SYMPOSIUM Toward a sex dimorphic neurology


16.00 W.A. Rocca (USA): Sex, gender and Parkinson’s disease

16.20 M.M. Mielke (USA): Sex, gender and dementia

16.40 K. Kantarci (USA): Hormone therapy and dementia risk in women

17.00 V.M. Miller (USA): Sex, gender, hormones and neurovascular aging



FEBRUARY 19

SYMPOSIUM - Sex differences and effects of neuroactive steroids on brain mitochondrial function and metabolism


9.00 M. Astiz (Germany): Developmental sex differences in the metabolism of cardiolipin in mouse cerebral cortex mitochondria

9.30 J.A. Chowen (Spain): Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes

10.00 G.E. Barreto (Colombia): Tibolone reduces oxidative damage and inflammation in microglia stimulated with palmitic acid through mechanisms involving estrogen receptor beta

10.30 A. Eckert (Switzerland): Effects of sex hormones on mitochondrial activity and bioenergetics – implications for Alzheimer’s disease

11.00-11.30 Coffee break

11.30-12.00  Free oral communications



12.15-13.00 SPECIAL LECTURE

N. Shah (USA)

Contextual control of innate social behaviors



 

13.00-15.00 Lunch and POSTER DISCUSSION



SYMPOSIUM Multi-faceted functions of estrogens in the ventromedial hypothalamic nucleus


15.00 Y. Xu (USA) An estrogen-responsive neural network: start from the ventromedial hypothalamic nucleus

15.30 M. López (Spain) Complex lipid metabolism within the VMH mediates the central actions of estradiol on energy balance

16.00 V. Routh (USA) Estrogen regulation of ventromedial hypothalamus glucose-inhibited neurons may play a role in glucose homeostasis

16.30 D. Lin (USA) The Esr1+ cells in ventromedial hypothalamus as an essential population for male and female aggression



21.00 SOCIAL DINNER


FEBRUARY 20


SYMPOSIUM - Molecular tools unleashed for the study of neuroactive steroid synthesis and action


9.00 L. Remage-Healey (USA): Viral targeting of neuronal subtypes to dissect rapid neurosteroid regulation of sensory cortex

9.30 S. Moenter (USA): Estradiol feedback on the reproductive neuroendocrine system

10.00 I. Abraham (Hungary): Super-resolution imaging of rapid estradiol effects on surface movement of glutamate receptors in live neurons

10.30 T. Stincic (USA) Optogenetics and calcium imaging reveal novel actions of estrogenic signaling on hypothalamic circuits that regulate energy balance

 

11.00-11.30 Coffee break


11.45-12.30 PLENARY LECTURE

V. Prevot (France)

Hypothalamic circuits of reproduction and steroid hormones


12.30-13.30 Lunch


13.30-14.30 YOUNG INVESTIGATORS Symposium



SYMPOSIUM - Vitamin D and brain


14.30 M. Norlin (Sweeden) Vitamin D and the brain  - potential effects on steroidogenesis in the nervous system and possible role in the treatment of brain cancer

15.00 G.F. Jirikowski (Germany) Binding globulin for Vitamin D and localization in the nervous system

15.30 X. Cui (Australia) Vitamin D modulates dopamine development via its genetic and epigenetic actions

16.00-16.30 Coffee break


SYMPOSIUM - The impact of endocrine disrupting chemicals (EDCs) interfering with steroid signaling on neurodevelopment


16.30 E. Rissman (USA) Transgenerational actions of endocrine disrupting compounds on genes and behavior

17.00 W. Lichtensteiger (Switzerland) Genes controlling developmental processes in hippocampus as targets of behaviorally active chemicals: possible microRNA involvement

17.30 A. Parent (Belgium) Neuroendocrine disruption of puberty and reproduction

 


CLOSURE OF THE MEETING