Group Members‎ > ‎

Dr. Vadim Nikulin, Principal Investigator


Research Topics:

  • Neuronal oscillations
    • functional significance
    • synchronization and causality analysis
    • relation to evoked responses
    • cross-frequency neuronal interactions
    • complexity analysis
  • Clinical studies
    • cortico-muscular interactions in stroke
    • neuronal dynamics in deep brain structures (patients with Parkinson’s disease)
  • Development of the novel analytic and recording techniques for EEG/MEG
  • Transcranial magnetic stimulation in combination with EEG
  • Brain Computer Interface

Publications in peer-reviewed journals


  • Iscan Z, Nazarova M, Fedele T, Blagoveschenski E, Nikulin VV. Pre-stimulus Alpha Oscillations and Inter-subject Variability of Motor Evoked Potentials in Single- and Paired-Pulse TMS Paradigms. Frontiers Human Neuroscience 2016 (In Press).
  • Tugin S, Hernandez-Pavon H, Ilmoniemi R, Nikulin VV. Visual deviant stimuli produce mismatch responses in the amplitude dynamics of neuronal oscillations. NeuroImage 2016 (In Press).
  • Samek W, Blythe DA, Curio G, Müller KR, Blankertz B, Nikulin VV. Multiscale temporal neural dynamics predict performance in a complex sensorimotor task. NeuroImage 2016; 141: 291-303.  [pubmed]
  • Blythe DA, Nikulin VV, Müller KR. Robust Statistical Detection of Power-Law Cross-Correlation. Sci Rep. 2016; 6:27089.  [pubmed]
  • Fedele T, Blagovechtchenski E, Nazarova M, Iscan Z, Moiseeva V, Nikulin VV. Long-Range Temporal Correlations in the amplitude of alpha oscillations predict and reflect strength of intracortical facilitation: Combined TMS and EEG study. Neuroscience 2016; 331:109-119.  [pubmed]


  • Schaworonkow N, Blythe DA, Kegeles J, Curio G, Nikulin VV. Power-law dynamics in neuronal and behavioral data introduce spurious correlations. Human Brain Mapping. 2015; 36: 2901-2914.  [pubmed]
  • Waterstraat G, Burghoff M, Fedele T, Nikulin VV,Scheer HJ. Curio G. Non-invasive single-trial detection of human neocortical population spikes. NeuroImage. 2015; 105: 13-20.  [pubmed]
  • Hohlefeld FU, Ehlen F, Tiedt HO, Krugel LK, Horn A, Kühn AA, Curio G, Klostermann F, Nikulin VV. Correlation between cortical and subcortical neural dynamics on multiple time scales in Parkinson's disease.Neuroscience. 2015; 298: 145-160. [pubmed]
  • von Carlowitz-Ghori К, Bayraktaroglu Z , Waterstraat G, Curio G, Nikulin VV. Voluntary control of corticomuscular coherence strength through neurofeedback: A proof-of-principle study in healthy subjects. Neuroscience. 2015; 290: 243-254. [pubmed]


  • Dabek J, Nikulin VV, Ilmoniemi RJ. Detecting millisecond-range coupling delays between brainwaves in terms of power correlations by magnetoencephalography. J Neurosci Methods. 2014; 235:10-24. [pubmed]
  • Hohlefeld FU,Huchzermeyer C, Huebl J, Schneider GH, Bruecke C, Schoenecker T, Kuehn AA, Curio G, Nikulin VV. Interhemispheric functional interactions between the subthalamic nuclei of patients with Parkinson’s disease. EJN; 40: 3273-3283. [pubmed]
  • Haufe S, Dähne S, Nikulin VV. Dimensionality reduction for the analysis of brain oscillations. Neuroimage 2014; 101:583-597. [pubmed]
  • Sundgren M, Nikulin VV, Maurex L, Wahlin Å, Piehl F, Brismar T. P300 amplitude and response speed relate to preserved cognitive function in relapsing-remitting multiple sclerosis. Clinical Neurophysiology (In Press). [pubmed]
  • Nikulin VV, Fedele T, Mehnert J, Lipp A, Noack C, Steinbrink J, Curio G. Monochromatic Ultra-Slow (~ 0.1 Hz) oscillations in the human electroencephalogram and their relation to hemodynamics. NeuroImage. 2014; 97: 71-80. [pubmed]
  • Blythe DA, Haufe S, Muller KR, Nikulin VV. The effects of linear mixing in the EEG on Hurst exponent estimation. NeuroImage 2014; 99:377-387. [pubmed]
  • Dähne S, Nikulin VV, Ramírezd D, Schreier JP, Müller KR, Haufe S. Finding brain oscillations with power dependencies in neuroimaging data. NeuroImage 2014; 96: 334-348.[pubmed]
  • Thiel SD, Bitzer S, Nierhaus T, Kalberlah C, Preusser S, Neumann J, Nikulin VV, van der Meer E, Villringer A, Pleger B. Hysteresis as an implicit prior in tactile spatial decision making. PLoS One. 2014 Feb 26;9(2): e89802. [plos one - open access]
  • Daehne S, Meinecke FC, Haufe S, Hoehne J, Tangermann M, Muller KR, Nikulin VV. SPoC: a novel method for obtaining a maximized correlation between amplitude of neuronal oscillations and cognitive variables. NeuroImage 2014; 86:111-122. [neuroimage - open access]
  • Herrojo Ruiz M, Brücke C, Nikulin VV, Schneider GH, Kühn AA. Beta-band amplitude oscillations in the human internal globus pallidus support the encoding of sequence boundaries during initial sensorimotor sequence learning. NeuroImage 2014; 85: 779-793 [pubmed]
  • Carlowitz-Ghori K, Bayraktaroglu Z, Hohlefeld FU, Losch F, Curio G, Nikulin VV. Corticomuscular Coherence in Acute and Chronic Stroke. Clinical Neurophysiology 2014; 125: 1182-1191. [pubmed]


  • Ilmoniemi RJ, Nikulin VV. Spatiotemporal dynamics and background neuronal states of the brain: implications for neuroimaging. Imaging Med 2013; 5: 403-406.
  • Nierula B, Hohlefeld FU, Curio G, Nikulin V. No somatotopy of somatosensory alpha oscillation responses to differential finger stimulation. NeuroImage 2013; 76: 294-303.[pubmed]
  • Hohlefeld FU, Ehlen F, Krugel LK, Kühn AA, Curio G, Klostermann F, Nikulin VV. Modulation of cortical neural dynamics during thalamic deep brain stimulation in patients with essential tremor. NeuroReport 2013; 24:751-756. [pubmed]
  • Hohlefeld FU, Huchzermeyer C, Huebl J, Schneider GH, Nolte G, Brücke, C, Schönecker T, Kühn AA, Curio G, Nikulin VV. Functional and effective connectivity in the subthalamic nucleus of patients with Parkinson’s Disease. Neuroscience 2013; 250:320-323. [pubmed]
  • Haufe S, Nikulin VV, Müller KR, Nolte G. A critical assessment of connectivity measures for EEG data: a simulation study. NeuroImage 2013; 64:120-133. [pubmed]
  • Bayraktaroglu Z, von Carlowitz-Gori K, Losch F, Nolte G, Curio G, Nikulin VV. It is not all about phase: amplitdue dynamics in corticomuscular interactions. NeuroImage 2013; 64: 496-504. [pubmed]


  • Hardstone R, Poil SS, Schiavone G, Jansen R, Nikulin VV, Mansvelder HD, Linkenkaer-Hansen K.Detrended fluctuation analysis: a scale-free view on neuronal oscillations. Front Physiol 2012; 3, 450. [frontiers - open acess]
  • Hohlefeld FU, Huebl J, Huchzermeyer C, Schneider GH, Schönecker T, Kühn AA, Curio G, Nikulin VV. Long-range temporal correlations in the subthalamic nucleus of patients with Parkinson's Disease. European Journal of Neuroscience 2012; 36: 2812-2821. [pubmed]
  • Nikulin VV, Jönsson EG, Brismar T. Attenuation of long-range temporal correlations in the amplitude dynamics of alpha and beta neuronal oscillations in patients with schizophrenia. NeuroImage 2012; 61: 162-169. [neuro image - open acess]
  • Nikulin VV, Nolte G, Curio G. Cross-frequency decomposition: A novel technique for studying interactions between neuronal oscillations with different frequencies. Clin Neurophysiol 2012; 123: 1353-1360. [pubmed]


  • Bayraktaroglu Z, von Carlowitz-Gori K, Losch F, Nolte G, Curio G, Nikulin VV. Optimal imaging of cortico-muscular coherence through a novel regression technique based on multi-channel EEG and un-rectified EMG. NeuroImage 2011; 57: 1059-1067. [pubmed]
  • von Carlowitz-Gori K, Hohlefeld FU, Bayraktaroglu Z, Curio G, Nikulin VV. Effect of complete stimulus predictability on P3 and N2 components: An EEG study. NeuroReport 2011, 22: 459-463. [pubmed]
  • Nikulin VV, Nolte G, Curio G. A novel method for reliable and fast extraction of neuronal EEG/MEG oscillations on the basis of spatio-spectral decomposition. NeuroImage 2011; 55: 1528–1535. [pubmed]
  • Hohlefeld FU, Nikulin VV, Curio G. Visual stimuli evoke rapid activation (120ms) of sensorimotor cortex for overt but not for covert movements. Brain Res. 2011; 1368: 185–195. [pubmed]
  • Stępień M, Conradi J, Waterstraat G, Hohlefeld FU, Curio G, Nikulin VV. Event-related desynchronization of sensorimotor EEG rhythms in hemiparetic patients with acute stroke. Neuroscince Letters 2011; 488: 17–21. [pubmed]
  • Hohlefeld FU, Nikulin VV, Curio G. Covert movements trigger repetition suppression of electroencephalography in sensorimotor cortex. NeuroReport 2011; 22: 141–145. [pubmed]


  • Nikulin VV, Kegeles J, Curio G. Miniaturized electroencephalographic scalp electrode for optimal wearing comfort. Clin Neurophysiol. 2010; 121:1007-1014. [pubmed]
  • Telenczuk B*, Nikulin VV*, Curio G. Role of Neuronal Synchrony in the Generation of Evoked EEG/MEG Responses. J Neurophysiol. 2010; 104:3557-3567. (* Both authors equally contributed to the study). [journal of neurophysiology - open access]
  • Nikulin VV, Linkenkaer-Hansen K, Nolte G, Curio G. Non-zero mean and asymmetry of neuronal oscillations have different implications for evoked responses. Clin Neurophysiol. 2010; 121:186–193. [pubmed]


  • Nikulin VV, Marzinzik F, Wahl M, Schneider GH, Kupsch A, Curio G, Klostermann F. Anticipatory activity in the human thalamus is predictive of reaction times. Neuroscience 2008; 155: 1275–1283. [pubmed]
  • Bikmullina R, Kičić D, Carlson S, Nikulin VV. Electrophysiological correlates of short-latency afferent inhibition: combined EEG and TMS study. Exp. Brain Res. 2009; 194:517–526. [pubmed]


  • Nikulin VV, Hohlefeld FU, Jacobs AM, Curio G. Quasi-movements: a novel motor cognitive phenomenon. Neuropsychologia, 2008; 46: 727–742. [pubmed]
  • Haufe S, Nikulin VV, Ziehe A, Müller KR, Nolte G. Combining sparsity and rotational invariance in EEG/MEG source reconstruction. NeuroImage 2008; 42: 726–738.. [pubmed]
  • Kicic D, Lioumis P, Ilmoniemi RJ, Nikulin VV. Bilateral changes in excitability of sensorimotor cortices during unilateral movement: Combined electroencephalographic and transcranial magnetic stimulation study. Neuroscience 2008; 152: 1119–1129. [pubmed]
  • Nolte G, Ziehe A, Nikulin VV, Schlogl A, Kramer N, Brismar T, Mueller KR. Robustly estimating the flow direction of information in complex physical systems. Phys Rev Lett. 2008; 100: 234101. [pubmed]


  • Klostermann F, Nikulin VV, Kuhn AA, Marzinzik F, Wahl M, Pogosyan A, Kupsch A, Schneider GH, Brown P, Curio G. Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures. Eur. J. Neurosci. 2007; 25:1604–1615. [pubmed]
  • Korostenskaja M, Nikulin VV, Kicic D, Nikulina AV, Kahkonen S. Effects of NMDA receptor antagonist memantine on mismatch negativity. Brain Res. Bull. 2007; 72: 275–283. [pubmed]
  • Nikulin VV, Linkenkaer-Hansen K, Nolte G, Lemm S, Müller KR, Ilmoniemi RJ, Curio G. A novel mechanism for evoked responses in the human brain. Eur. J. Neurosci. 2007; 25: 3146–3154. [pubmed]


  • Nikulin VV, Brismar T. Phase synchronization between alpha and beta oscillations in the human electroencephalogram. Neuroscience 2006; 137: 647–657. [pubmed]


  • Nikulin VV, Brismar T. Long-range temporal correlations in electroencephalographic oscillations: Relation to topography, frequency band, age and gender. Neuroscience. 2005; 130:549–558. [pubmed]
  • Pulvermuller F, Hauk O, Nikulin VV, Ilmoniemi RJ. Functional links between motor and language systems. Eur. J. Neurosci. 2005; 21: 793–797. [pubmed]
  • Nikulin VV, Nikulina AV, Yamashita H, Rossi EM, Kahkonen S. Effects of alcohol on spontaneous neuronal oscillations: a combined magnetoencephalography and electroencephalography study. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005; 29: 687–693. [pubmed]
  • Carlqvist H, Nikulin VV, Stromberg JO, Brismar T. Amplitude and phase relationship between alpha and beta oscillations in the human electroencephalogram. Med. Biol. Eng. Comput. 2005; 43: 599–607. [pubmed]


  • Linkenkaer-Hansen K, Nikulin VV, Palva JM, Kaila K, and Ilmoniemi RJ. Stimulus-induced change in long-range temporal correlations and scaling behavior of sensorimotor oscillations. Eur. J. Neurosci. 2004; 19: 203–211. [pubmed]
  • Nikulin VV, Brismar T. Comment on ``Multiscale entropy analysis of complex physiologic time series''. Phys. Rev. Lett. 2004; 92:089803. [pubmed]
  • Nikulin VV, Brismar T. Long-range temporal correlations in alpha and beta oscillations: effect of arousal level and test-retest reliability. Clin Neurophysiol. 2004, 115:1896–1908. [pubmed]
  • Linkenkaer-Hansen K, Nikulin VV, Palva S, Ilmoniemi RJ, Palva JM. Prestimulus oscillations enhance psychophysical performance in humans. J. Neurosci. 2004; 24: 10186–10190. [journal of neuroscience - open access]
  • Maltez J, Hyllienmark L, Nikulin VV, Brismar T. Time course and variability of power in different frequency bands of EEG during resting conditions. Neurophysiol Clin. 2004; 34: 195–202. [pubmed]


  • Kähkönen S, Wilenius J, Nikulin VV, Ollikainen M, Kesäniemi M, and Ilmoniemi RJ. Alcohol reduces prefrontal cortical excitability in humans. A combined TMS and EEG study. Neuropsychopharmacology 2003; 28: 747–754. [neuropsychopharmacology - open access]
  • Nikulin VV, Kičić D, Kähkönen S, and Ilmoniemi RJ. Modulation of electroencephalographic responses to TMS: evidence for changes in cortical excitability related to movement. Eur. J. Neurosci. 2003; 18: 1206–1212. [pubmed]
  • Kähkönen S, Ahveninen J, Jääskeläinen I, Pennanen S, Liesivuori J, Nikulin VV. Acute tryptophan depletion does not change somatosensory evoked magnetic fields. Psychopharmacology 2003; 170: 332–333. [pubmed]


  • Komssi S, Aronen HJ, Huttunen J, Kesäniemi M, Soinne L, Nikouline VV, Ollikainen M, Roine RO, Karhu J, Savolainen S, Ilmoniemi RJ. Interhemispheric functional connectivity measured with transcranial magnetic stimulation and electroencephalography. Clin. Neurophysiol. 2002; 113: 175–184.
  • Pihko E, Nikulin VV, Ilmoniemi RJ. Visual attention to words in different languages in bilinguals: a magnetoencephalographic study. Neuroimage, 2002; 17: 1830–1836. [pubmed]


  • Nikouline VV, Linkenkaer-Hansen K, Wikström H, Kesäniemi M, Antonova EV, Ilmoniemi RJ, Huttunen J. Dynamics of mu-rhythm suppression caused by median nerve stimulation: a magnetoencephalographic study. Neurosci. Lett. 2001; 294: 163–166. [pubmed]
  • Schürmann M, Nikouline VV, Soljanlahti S, Ollikainen M, Basar E, Ilmoniemi RJ. EEG responses to combined somatosensory and transcranial magnetic stimulation. Clin. Neurophysiol. 2001; 112: 19–24. [pubmed]
  • Linkenkaer-Hansen K, Nikouline VV, Palva M, and Ilmoniemi RJ. Long range temporal correlations and scaling behavior in human brain oscillations. J. Neurosci. 2001; 21: 1370–1377. [journal of neuroscience - open access]
  • Kähkönen S, Kesäniemi M, Nikouline VV, Karhu J, Ollikainen M, Holi M, and Ilmoniemi RJ. Ethanol modulates cortical activity: direct evidence with combined TMS and EEG. NeuroImage 2001; 14: 322–328. [pubmed]
  • Nikouline VV, Linkenkaer-Hansen K, Huttunen J, Ilmoniemi RJ. Interhemispheric phase synchrony and amplitude correlation of spontaneous beta oscillations in human subjects: a magnetoencephalographic study. NeuroReport 2001; 12: 2487–2491. [pubmed]
  • Pihko E, Mäkinen V, Nikouline VV, Mäkelä AM, Ilmoniemi RJ. Visual attention to words of native versus later acquired languages is reflected in MEG responses. Neurosci. Lett. 2001; 310: 33–36. [pubmed]
  • Anourova I, Nikouline VV, Ilmoniemi RJ, Hotta J, Aronen HJ, Carlson S. Evidence for dissociation of spatial and nonspatial auditory information processing. NeuroImage 2001; 14: 1268–1277. [pubmed]
  • Kähkönen S, Holi M, Wilenius J, Karhu J, Nikouline VV, Bailey CJ, Ilmoniemi RJ. The functional connectivity of the prefrontal cortex studied by combined TMS with EEG. Biomed. Tech. 2001; 46: 257–259.


  • Nikouline VV, Wikström H, Linkenkaer-Hansen K, Kesäniemi M, Ilmoniemi RJ, Huttunen J. Somatosensory evoked magnetic fields: relation to pre-stimulus mu rhythm. Clin. Neurophysiol. 2000; 111: 1227–1233. [pubmed]
  • Ruohonen J, Ollikainen M, Nikouline V, Virtanen J, Ilmoniemi RJ. Coil design for real and sham transcranial magnetic stimulation. IEEE Trans. Biomed. Eng. 2000; 47: 145–148. [pubmed]
  • Kliucharev VA, Nikulin VV, Ponomarev VA. The influence of emotionally significant visual stimuli on cortical evoked potentials. Human Physiology 2000; 26: 5–13.


  • Nikouline V, Ruohonen J, Ilmoniemi RJ. The role of the coil click in TMS assessed with simultaneous EEG. Clin. Neurophysiol. 1999; 110: 1325–1328. [pubmed]
  • Nikulin VV, Kulikov GA. The escape reactions in cats during electrical stimulation of the hypothalamus leading to the occurrence of aggressive behavior. Zh. Vyssh. Nerv. Deiat. Im I P Pavlova 1999, 49: 211–219. [pubmed]


  • Nikulin VV, Perfil'ev SN, Varfolomeev AL. The electrical activity of the sensorimotor areas of the cat cerebral cortex in the presence of a unilateral instrumental reflex. Fiziol. Zh Im I M Sechenova 1996, 82:26–35. [pubmed]