Dr. Nese Sreenivasulu Research Page

Head, Grain Quality and Nutrition Center, International Rice Research Institute, Metro Manila, Philippines

Researcher ID: E-8600-2011  

Dr. Nese Sreenivasulu has nearly 10 years research experience in plant functional genomics. Since 2013, he is Head of Grain Quality and Nutrition Center at International Rice Research Institute. He provides scientific leadership for IRRI's research program on grain quality and nutritional value using multi-disciplinary approaches such as genomics, genetics and biochemistry. Previously he employed as Head of Stress Genomics group of Interdisziplinäres Zentrum für Nutzpflanzenforschung (IZN) at Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) addressing the molecular mechanisms of stability of seed yield under drought mainly addressing altered grain number and seed filling efficiency. He holds adjunct position in the school of Plant Biology at University of Western Australia

Educational Background and Professional experience: In 1995 he obtained M.Phil degree in Seed Technology from University of Mysore. He then moved to IPK and established genomics platform in barley crop. Using this genomics platform he studied seed development of barley grain in a model mutant system seg8 and obtained his PhD degree from Martin Luther University, Germany during 2002. Following after completion of the PhD, he continued as Post-Doctoral Research scientist at IPK and revealed regulatory networks operate during barley seed development using introgression line population. During 2007, he is employed as Project Leader engaging in coordinating major project funded from German Ministry (BMBF) entitled “SEEDs for the FUTURE: developing barley lines with improved yield and grain quality under drought stress during seed filling (GABI-GRAIN)”. In addition he is also involved in additional grants, leading research towards systems biology, where ‘developing barley seed’ is the main objective. 

Scientific background: Dr. Sreenivasulu has excellent publication record, published 72 research articles in esteemed international journals of repute with high impact factors (Nature Genetics, Nature Plants, Scientific Reports, Annual Review of Plant Biology, Trends in Plant Science, PNAS, Plant Journal, Plant Physiology, Plant Molecular Biology, Plant Biotechnology Journal, Genetics, Frontiers in Plant Science, International Review of Cell and Molecular Biology, Molecular Genetics and Genomics, Functional Integrative genomics, New Phytologist, Theoretical and applied Genetics, Molecular Breeding, Gene, Physiologia Plantarum, Plant science, Journal of Plant Physiology, Cell Biology International, Current Science, BMC Bioinformatics, BMC Plant Biology, Frontiers in Plant Science etc). In addition 16 book chapters and 10 proceedings have been published.

Leadership: Providing scientific leadership for IRRI’s research on grain quality (physical, sensory, cooking) and nutritional qualities of rice research using holistic approaches such as biochemistry, genetic and genomics. Dr. Sreenivasulu is responsible for implementing grain quality research, including overseeing more than 35 staff, analytical services and other resources in IRRI’s Grain Quality Nutrition Center. Developing stronger partnerships with leaders of other IRRI Programs to ensure full integration of grain quality and nutrition research and analytical services in IRRI’s varietal improvement programs, towards creating product-oriented breeding pipelines that meet the demand of rice farmers, millers, processors and consumers.

Coordination: Coordinated 5 mega projects worth of more than 8 Million US Dollars and also participated as a principal investigator in several projects in the area of abiotic stress tolerance, seed biology, grain quality and nutrition. The successful outcome of the team work is documented as a list of publications in a separate section.

 Ongoing Projects at IRRI:

* Stress-tolerant rice for poor farmers in Africa and South Asia (STRASA) (Phase 3), funded by Bill and Melinda Gates Foundation, from 2014 to 2019 (participated as Co-PI for grain quality research with own project budget of 300,000 USD; total budget of the project 33 Million USD)

* Reducing impacts of high night temperature on rice harvests and farmers livelihoods in South Asia and South East Asia, funded by BMZ (1.2 Million Euro) from 2017 till 2019  [Coordinator: Nese Sreenivasulu]

* Slower digesting rice varieties, funded by ICAR-IRRI collaborative project (300,000 USD) from 2013 till 2016  [Coordinator: Nese Sreenivasulu] 

* Enhanced cooking quality of rice, funded by Syngenta SKEP III project (525,000 USD) from 2016-2019 2016  [Coordinator: Nese Sreenivasulu] 

* Enhanced rice quality for health (EnRicH), Newton funding initiative funded by BBSRC, UK (650,000 British pound; own funding of 314,000 USD) [Coordinator: Alison Lovegrove and CoPI Nese Sreenivasulu]

* Identification and validation of functional markers from diverse germplasm to reduce chalk in rice breeding materials, funded by Australian Centre for International Agricultural Research – Australia, from 2014 till 2017 (250,000 AusDollars) [Coordinator: Nese Sreenivasulu] 

Projects completed at IPK:

* BMBF: SEEDS for the FUTURE: Developing barley lines with improved yield and grain quality under drought stress during seed filling (GABI-GRAIN). Project budjet:  2.1 Million  Euros, Project duration: 2007 to 2010 (Coordinator: N. Sreenivasulu and Co-coordinator: U. Wobus). GABI-GRAIN Webpage

  * BMBF: Integrated modelling of the primary metabolism of the developing barley endosperm as influenced by hormonal modulations (GABI-SysSEED). Project budjet: 1.7 Million  Euros, Project duration: 2007 to 2010 (involved in WP B2). GABI-SysSEED Webpage

 * BMBF International Büro-DBT joint project: Transcriptome based identification of overlapping responses of salt and drought tolerance and comparative genome mapping-tagging of stress responsive genes. Project budjet: 6.140,00 Euro + Sixty lakhs Rupees, Project duration: 2008 to 2010 (German Coordinator: N. Sreenivasulu and Indian Coordinator: M. Prasad). IB-BMBF-DBT project Webpage

*  BMBF International Büro (Germany) - Department of Science and Technology (India) joint project funding: “Developing sustainable transgenic crop plants for drought or a combination of drought and heat stress by manipulating ABA signaling and Ascorbate- Glutathione pathways (PRO-DROUGHT)”. Total Project budget of German funding: 400,000 Euro  + 314,200 Euro Indian funding, plus travel grants between the two countries. Project duration: 12/2010 to 11/2013. [Coordinator: Nese Sreenivasulu]
*  BMELV funding: “Developing stress tolerant barley lines with improved seed set and yield during anthesis” (SEED-SET). Total Project budget: 719,324 Euro. Project duration: 02/2011 to 01/2014. [Coordinator: Nese Sreenivasulu]
*  Research group establishment by the funding of Ministery of Culture of Saxony-Anhalt in the frame of the Interdisziplinäres Zentrum für Nutzpflanzenforschung (IZN): “Exploring yield enhancement genes influencing grain number and seed growth under drought”. Total Project budget: 625,300 Euro. Project duration: 11/2010 to 10/2015. [Head of the group Stress Genomics: Nese Sreenivasulu]
*  BMZ funding of a joint project between IPK (Germany) and IRRI (Phillipines): “From QTLs to Variety: pyramiding major drought-responsive QTLs for sustainable rice yields in Asia and Africa” Total Project budget:  1.2 Million Euro. (Own Project budget: 210,000 Euro). Project duration: 01/2011 to 12/2013. [Coordinator: Aravind Kumar]

*  BMBF funding: “Developing drought sustainable genotypes with improved seed yield and quality suitable for malting
(InnoGRAIN-MALT)”. Total Project budget:  1.16 Million Euro. (Own Project budget: 437,132 Euro). Project duration: 01/2012 to 12/2014. [Coordinator: Viktor Korzun]

  Awards and Fellowships:                 

  • Third Rank in M.Sc., Botany, 1995
  • DAAD Fellow, 1998


International/National Scientific activities:  

Reviewer for Journals:

  • Annals of Botany
  • BMC Systems Biology
  • BMC Plant Biology
  • FEBS,
  • Frontiers in Plant Science
  • Functional and Integrative Genomics
  • Journal of Plant Physiology
  • Journal of Agronomy and Crop Science
  • Molecular Genetics and Genomics,
  • Molecular Breeding
  • Molecular Biology Reports
  • New Phytologist
  • Proteomics
  • Planta
  • Plant Cell Reports
  • Plant and Cell Physiology
  • Plant Molecular Biology,
  • Plant Biotechnology Journal
  • Plant Physiology
  • Plos One
  • The Plant Cell
  • Trends in Plant Science

Editorial Board member:   

  • BMC Plant Biology (Associate Editor)
  • Plant Cell Reports (Associate Editor)
  • Frontiers in Plant Science (Review Editor)

Reviewer for grant applications:   

  • National Science Foundation (NSF), USA
  • United States-Israel Binational Science Foundation (BSF)
  • The French National Research Agency (ANR)


Total Papers published:

Citation Index: For published papers of N. Sreenivasulu, in total 2615 citations were indexed by ISI with H-index value of 28 and as per Google Scholar database 4647 citations indexed with H-index value of 34.

Peer reviewed research papers published:          72

Peer reviewed book chapters published:              16

Peer reviewed proceedings published:                 10

 Research Publications  ( * corresponding author, + contributed equally as first author)

I. Seed Development and yield forming factors -Omics

  • 72. V.M. Butardo, R. Anacleto, S. Parween, I. Samson, K. Guzman, C.M. Alhambra, G. Misra, N. Sreenivasulu*. Systems genetics identifies a novel regulatory domain of amylose synthesis. Plant Physiol. 2016 Nov 23. Doi: pp.01248.2016.  
  • 71. H.M. Youssef, K. Eggert, R. Koppolu, A.M. Alqudah, N. Poursarebani, A. Fazeli, S. Sakuma, A. Tagiri, T. Rutten, G. Govind, U. Lundqvist, A. Graner, T. Komatsuda, N. Sreenivasulu, T. Schnurbusch. VRS2 regulates hormone-mediated inflorescence patterning in barley. Nature Genetics 49(1):157-161, 2017. 
  • 70. M.R. Ghaffari, F. Shahinnia, B. Usadel, B. Junker, F. Schreiber, N. Sreenivasulu, M.R. Hajirezaei. The Metabolic Signature of Biomass Formation in Barley. Plant and Cell Physiology 57(9):1943-60, 2016 
  • 69. V.M. Jr Butardo, N. Sreenivasulu*. Tailoring grain storage reserves for a healthier rice diet and its comparative status with cereals. International Review of Cell andMolecular Biology 323: 31-70, 2016. 
  • 68. T.Kretzschmar, M.A.F. Pelayo, K.R. Trijatmiko, L. Franz, M. Gabunada, R.A. Rosario Jimenez, M.S. Mendioro, I.H. Slamet-Loedin, N. Sreenivasulu, J. Bailey-Serres, A.M. Ismail, D.J. Mackill and E.M. Septiningsih.  A trehalose-6-phosphate phosphatase enhances anaerobic germination tolerance in rice. Nature Plants 1: 15124, 2015. Doi:10.1038/nplants.2015.124. (14 times cited)
  • 67. R. Anacleto, R.P. Cuevas, R. Jimenez, C. Llorente, E. Nissila, R. Henry, N. Sreenivasulu*. Prospects of breeding high-quality rice using post-genomic tools. Theoretical and Applied Genetics 128(8):1449-66, 2015. (6 times cited
  • 66. N. Poursarebani, T. Seidensticker, R. Koppolu, C. Trautewig, P. Gawroński, F. Bini, G. Govind, T. Rutten, S. Sakuma, A. Tagiri, G.M. Wolde, H.M. Youssef, A. Battal, S. Ciannamea, T. Fusca, H.M. Youssef, T. Nussbaumer, C. Pozzi, A. Börner, U. Lundqvist, T. Komatsuda, S. Salvi, R. Tuberosa, C. Uauy, N. Sreenivasulu, L. Rossini, T. Schnurbusch. The Genetic Basis of Composite Spike Form in Barley and "Miracle-Wheat". Genetics 2015. Jul 7. pii: genetics.115.176628. (2 times cited)
  • 65. N. Sreenivasulu* and U. Wobus*. Comparative seed development and its implications in addressing yield stability. Annual review of Plant Biology 64:189-217, 2013. (68 times cited)
  • 64. R. Koppolu, N. Anwar, S. Sakuma, A. Tagiri, U. Lundqvist, M. Pourkheirandish, T. Rutten, C. Seiler, A. Himmelbach, R. Ariyadasa, H.M. Youssef, N. Stein, N. Sreenivasulu, T. Komatsuda, Schnurbusch T. Six-rowed spike4 (Vrs4) controls spikelet determinacy and row-type in barley. Proc Natl Acad Sci U S A. 110(32):13198-203, 2013. (28 times cited)
  • 63. N. Sreenivasulu* and T. Schnurbusch. A genetic playground for enhancing grain number in cereals.Trends in Plant Science. 17: 91-101, 2012. (60 times cited)
  • 62. V. Radchuk, J. Kumlehn, T. Rutten, N. Sreenivasulu, R. Radchuk, H. Rolletschek, C. Herrfurth, I. Feussner and L. Borisjuk. Fertility in barley flowers depends on jekyll functions in male and female sporophytes. New Phytologist. 194: 142-157, 2012. (5 times cited)
  • 61. G. Melkus, H. Rolletschek, J. Fuchs, V. Radchuk, E. Grafahrend-Belau, N. Sreenivasulu, T. Rutten, D. Weier, N. Heinzel, F. Schreiber, T. Altmann, P.M. Jakob, L. Borisjuk. Dynamic (13) C/(1) H NMR imag
    ing uncovers sugar allocation in the living seed. Plant Biotechnol J. 9: 1022-1037, 2011.          (36 times cited)
  • 60. N. Sreenivasulu, L. Borisjuk, B. Junker, H.P. Mock, H. Rolletschek, U. Seiffert, W.    Weschke, and U. Wobus. Barley grain development: towards an integrative view.              International Review of Cell and Molecular Biology 281: 49-89, 2010. (42 times cited)
  • 59. N. Sreenivasulu, V. V. Radchuk, B. Grimm, L. Borisjuk, D. Weier, J. Fuchs, O. Miersch, B. Usadel, U. Wobus, and W. Weschke. The predicted role of ABA in endosperm cell cycle regulation as revealed by analysis of the maternal effect barley mutant seg8 defected in starch accumulation. The Plant Journal 64: 589-603, 2010. (28 times cited)
  • 58. S. Sharma, N. Sreenivasulu, V.T. Harshavardhan, C. Seiler, S. Sharma, Z.N. Khalil, E. Akhunov, S.K. Sehgal, M.S. Röder. Delineating the structural, functional and evolutionary relationships of sucrose phosphate synthase gene family II in wheat and related grasses. BMC Plant Biology 10: 134, 2010. (8 times cited)
  • 57. N. Weichert, I. Saalbach, H. Weichert, S. Kohl, A. Erban, J. Kopka, B. Hause, A. Varshney, N. Sreenivasulu, M. Strickert, J. Kumlehn, W. Weschke and H. Weber. Increasing sucrose uptake capacity of wheat grains stimulates storage protein synthesis. Plant Physiology 152: 698-710, 2010. [This article has been selected for focus collections “Plants Systems Biology 2010”] (63 times cited)
  • 56. V. V. Radchuk, L. Borisjuk, N. Sreenivasulu, K. Mercx, H.P. Mock, H. Rolletschek, U. Wobus, and W.         Weschke. Spatio-temporal profiling of starch biosynthesis and degradation in the developing barley grain.             Plant Physiology 150: 190-204, 2009. (76 times cited)
  • 55. C.Pietsch+, N. Sreenivasulu+, U. Wobus, and M. Roeder. Linkage mapping of putative regulator genes of barley grain development characterized by expression profiling. BMC Plant Biology. 9: 4, 2009. Pdf file           (6 times cited)
  • 54. N. Sreenivasulu*, A. Graner, and U. Wobus. Barley genomics: an overview.  International Journal of Plant Genomics. 486258, 2008. Pdf file (51 times cited)
  • 53. N. Sreenivasulu*, B. Usadel, A. Winter, V. Radchuk, U. Scholz, N. Stein, W. Weschke, M. Strickert, T.J. Close, M. Stitt, A. Graner, and U. Wobus. Barley grain maturation and germination: Metabolic pathway and regulatory network commonalities and differences highlighted by new MapMan/PageMan profiling tools. Plant Physiology 146: 1738-1758, 2008. Pdf file [This article has been selected for focus collections  “Plants Systems Biology 2010”] (176 times cited
  • 52. J. Thiel, D. Weier, N. Sreenivasulu, M. Strickert, N. Weichert, M. Melzer, T. Czauderna, U. Wobus, H.          Weber, and W. Weschke. Different hormonal regulation of cellular differentiation and function in  nucellar               projection and endosperm transfer cells: A microdissection-based transcriptome study of young barley grains.      Plant Physiology 148: 1436-1452, 2008. (75 times cited)
  • 51. T. Neuberger+, N. Sreenivasulu+, M. Rokitta, H. Rolletschek, C. Göbel, T. Rutten, V. Radchuk, I. Feussner, U. Wobus, P. Jakob, A. Webb, L. Borisjuk. Quantitative imaging of oil storage in developing crop seeds. Plant Biotechnology Journal  6: 31-45, 2008. Pdf file (47 times cited
  • 50. H.S. Balyan, N. Sreenivasulu, O. Riera-Lizarazu, P. Azhaguvel, and S.F. Kianian. Mutagenesis and              high-throughput functional genomics in cereal crops: Current status. Advances in Agronomy 98: 357-414, 2008. (9 times cited)
  • 49.  V. Radchuk, N. Sreenivasulu, B. Yaroslav, and W. Weschke. Cloning and expression of the tubulin genes in barley. Cell Biology international 32(5): 557-559, 2008. (5 times cited)
  • 48.  V. Radchuk, N. Sreenivasulu, B. Yaroslav, and W. Weschke. Distinct tubulin genes are differentially expressed during barley grain development. Physiologia Plantarum 131(4): 571-580, 2007. (9 times cited)
  • 5. M. Strickert+, N. Sreenivasulu+, B. Usadel, U. Seiffert. Correlation-maximizing surrogate gene space for visual mining of gene expression patterns in developing barley endosperm tissue. BMC Bioinformatics 8: 165, 2007 Pdf file (21 times cited
  • 47. N. Sreenivasulu,  V. Radchuk, M. Strickert, O. Miersch, W. Weschke and U. Wobus. Gene expression patterns reveal  tissue-specific  signaling  networks  controlling  programmed  cell  death and  ABA-regulated maturation  in  developing  barley  seeds.  The Plant Journal  47(2): 310-327, 2006.   Pdf file  [Including cover page title] (147 times cited)
  • 46. V. Radchuk,  N. Sreenivasulu,  R.I. Radchuk,  U. Wobus and W. Weschke. The methylation cycle and its possible function during barley endosperm development. Plant Molecular Biology 59(2): 289-306, 2005.   Pdf file (38 times cited)
  • 45.  N. Sreenivasulu, L. Altschmied, V. Radchuk, S. Gubatz, U. Wobus and W. Weschke. Transcript profiles and deduced changes of metabolic pathways in maternal and filial tissues of developing barley grains. The Plant Journal 37 (4): 539-553, 2004.   Pdf file (119 times cited) 
  • 44. H. Zhang+, N. Sreenivasulu+, W. Weschke, N. Stein, S. Rudd, V. Radchuk, E. Potokina, U. Scholz, P. Schweizer, U. Zierold, P. Langridge, R.K. Varshney, U. Wobus and A. Graner. Large-Scale Analysis of the Barley Transcriptome Based on Expressed Sequence Tags (ESTs). The Plant Journal 40 (2): 276-290, 2004.  Pdf file (130 times cited)  
  • 43. E. Potokina , M. Caspers, M. Prasad, R. Kota, H. Zhang, N. Sreenivasulu, M. Wang and A. Graner. Functional association between malting quality trait components and cDNA array based expression patterns in barley (Hordeum vulgare L.) Molecular Breeding 14 (2): 153-170, 2004.   Pdf file (76 times cited) 
  • 42. N. Sreenivasulu, L. Altschmied, R. Panitz, U. Hähnel, W. Michalek, W. Weschke and   U. Wobus. Identification of genes specifically expressed in maternal and filial tissues of barley caryopses: a cDNA array analysis. Molecular Genetics and Genomics 266: 758-767, 2002b.  Pdf file (72 times cited) 
  • 41. N. Sreenivasulu, P.B. Kavi Kishor, R.K. Varshney and L. Altschmied. Mining functional information from cereal genomes- the utility of expressed sequence tags (ESTs)- (Review article) Current Science 83 (8): 1-9, 2002a.  Pdf file (29 times cited)
  •  40. E. Potokina, N. Sreenivasulu, L. Altschmied, W. Michalek and A. Graner. Differential gene expression during seed germination in barley (Hordeum vulgare L). Functional and Integrative Genomics 2: 28-39, 2002.  Pdf file (100 times cited)

II. Abiotic Stress Tolerance

  • 39. H. Ji, S.R. Kim, Y.H. Kim, J.P. Suh, H.M. Park, N.Sreenivasulu, G. Misra, S.M. Kim, S.L. Hechanova, H. Kim, G.S. Lee, U.H. Yoon, T.H.  Kim, H. Lim, S.C. Suh, J. Yang,G.  An, K.K. Jena. Map-based Cloning and Characterization of the BPH18 Gene from Wild Rice Conferring Resistance to Brown Planthopper (BPH) Insect Pest. Scientific Reports. 6:34376, 2016; doi: 10.1038/srep34376. (1 times cited)
  • 38. S.A. Hosseini, M.R. Hajirezaei, C. Seiler, N. Sreenivasulu and N. Von Wirén. A potential role of flag leaf potassium in conferring tolerance to drought-induced leaf senescence in barley. Frontiers in Plant Science 7: 206, 2016; doi:10.3389/fpls.2016.00206
  • 37. S. Dixit, A.K. Biswal, A. Min, A. Henry, R.H. Oane, M.L. Raorane, T. Longkumer, I.M. Pabuayon, S.K. Mutte, A.R. Vardarajan, B. Miro, G. Govindan, B. Albano-Enriquez, M. Pueffeld, N. Sreenivasulu, I. Slamet-Loedin, K. Sundarvelpandian, Y.C. Tsai, S. Raghuvanshi, Y.I.C. Hsing, A. Kumar and A. Kohli. Action of multiple intra-QTL genes concerted around a colocalized transcription factor underpins a large effect QTL. Scientific Reports  5: 15183, 2015; doi: 10.1038/srep15183. (7 times cited)
  • 36. S.V.K. Jagadish, P.B. Kavi Kishor, R. Bahuguna, N. von Wiren and N. Sreenivasulu*. Staying alive or going to die during terminal senescence- An enigma surrounding yield stability. Frontiers in Plant Science 6: 1070, 2015. doi: 10.3389/fpls.2015.01070 (1 times cited)
  • 35. N. Sreenivasulu*, V.M. Jr Butardo, G. Misra, R.P. Cuevas, R. Anacleto, P.B. Kavi Kishor. Designing climate-resilient rice with ideal grain quality suited for high-temperature stress. Journal of Experimental Botany 2015 66(7):1737-1748(16 times cited)
  • 34. P.B. Kavi Kishor, P. Hima Kumari, M.S. Sunita, N. Sreenivasulu. Role of proline in cell wall synthesis and plant development and its implications in plant ontogeny. Frontiers in Plant Science 6: 544, 2015. doi: 10.3389/fpls.2015.00544  (8 times cited)
  • 33. M.L. Raorane, I.M. Pabuayon, B. Miro, R. Kalladan, M. Reza-Hajirezai, R.H. Oane, A. Kumar, N. Sreenivasulu, A. Henry, A. Kohli. Variation in primary metabolites in parental and near-isogenic lines of the QTL qDTY 12.1 : altered roots and flag leaves but similar spikelets of rice under drought. Molecular Breeding 35(6):138, 2015. (5 times cited)
  • 32. Harshavardhan VT, et al. AtRD22 and AtUSPL1, members of the plant-specific BURP domain family involved in Arabidopsis thaliana drought tolerance. PLoS One. 2014 Oct 15;9(10):e110065. doi: 10.1371/journal.pone.0110065. eCollection 2014. (16 times cited)
  • 31. C. Seiler, V.T. Harshavardhan, P.S. Reddy, G. Hensel, J. Kumlehn, L. -Lippold, K. Rajesh, V. Korzun, U. Wobus, J. Lee, G. Selvaraj, N. Sreenivasulu*. Abscisic Acid Flux Alterations Result in Differential Abscisic Acid Signaling Responses and Impact Assimilation Efficiency in Barley under Terminal Drought Stress. Plant Physiology. 2014 Apr;164(4):1677-96. (14 times cited)
  • 30. P.S. Reddy, P.B. Kavi Kishor, C. Seiler, M. Kuhlmann, L. Eschen-Lippold, J. Lee, M.K. Reddy, N. Sreenivasulu*. Unraveling Regulation of the Small Heat Shock Proteins by the Heat Shock Factor HvHsfB2c in Barley: Its Implications in Drought Stress Response and Seed Development. PLoSOne. 2014 Mar 4;9(3):e89125. doi: 10.1371/journal.pone.0089125. (24 times cited)
  • 29. P.B. Kavi Kishor and N. Sreenivasulu*. Is proline accumulation per se correlated with stress tolerance or is proline homoeostasis a more critical issue? Plant Cell and Environment 37(2): 300-311, 2014. (98 times cited)
  • 28. R. Kalladan, S. Worch, H. Rolletschek, V.T. Harshavardhan, L. Kunze, C. Seiler, N. Sreenivasulu and M.S. Röder. Identification of quantitative trait loci contributing to yield and seed quality parameters under terminal drought in barley advanced backcross lines. Molecular Breeding 32: 71-90, 2013. (14 times cited)
  • 27. A. Kohli, N. Sreenivasulu, P. Lakshmanan and P.P. Kumar. The phytohormone crosstalk paradigm takes center stage in understanding how plants respond to abiotic stresses. PlantCell Reports 32(7): 945-957, 2013. (65 times cited)
  • 26. S. Friedel, B. Usadel, N. vonWirén and N. Sreenivasulu*. Reverse engineering: a key component of systems biology to unravel global abiotic stress cross-talk. Frontiers in Plant Science, 3: 294, 2012. (22 times cited)
  • 25. N. Sreenivasulu*, V.T. Harshavardhan, G. Govind, C. Seiler and A. Kohli. Contrapuntal role of ABA: Does it mediate stress tolerance or plant growth retardaton under long-term drought stress?. Gene, 506(2): 265-273, 2012. (100 times cited)
  • 24. R.R. Mir, M. Zaman-Allah, N. Sreenivasulu, R. Trethowan and R.K. Varshney. Integrated genomics, physiology and breeding approaches for improving drought tolerance in crops. Theoretical and Applied Genetics, 125(4): 625-645, 2012. (185 times cited)
  • 23. S. Worch, R. Kalladan, V.T. Harshavardhan, C. Pietsch, V. Korzun, L. Kuntze, A. Borner, U. Wobus, M.S. Roder and N. Sreenivasulu*. Haplotyping, linkage mapping and expression analysis of barley genes regulated by terminal drought stress influencing seed quality.  BMC Plant Biology, 11: 1, 2011. (21 times cited)
  • 22. C. Seiler, V.T. Harshavardhan, K. Rajesh, M. Strickert, H. Rolletschek, U.Scholz, U., Wobus  and   N.            Sreenivasulu*. ABA biosynthesis and degradation contributing to ABA homeostasis during barley seed              development under control and terminal drought stress conditions. Journal of Experimental Botany, 62:           2615-2632, 2011. (104 times cited)
  • 21. G. Govind, C. Seiler, U. Wobus, N. Sreenivasulu*. Importance of ABA homeostasis under terminal drought stress in regulating grain filling events. Plant Signaling & Behavior, 6(8): 1228-1231, 2011. (9 times cited)
  • 20. S. Puranik, S.Jha, P.S. Srivastava, N. Sreenivasulu and M. Prasad. Comparative transcriptome of                salt-tolerant and salt-sensitive foxtail millet cultivars in response to short term salinity stress. Journal of Plant    Physiology, 168: 280-287, 2011. (44 times cited)
  • 19. C. Lata, S. Jha, V. Dixit, N. Sreenivasulu and M. Prasad. Differential antioxidative responses to dehydration-induced oxidative stress in core set of foxtail millet cultivars [Setaria italica (L.)]. Protoplasma, 248: 817-828, 2011. (26 times cited)
  • 18. N. Sreenivasulu*, R. Sunkar, U. Wobus and M. Strickert. Array platforms and bioinformatic tools for the        analysis of the plant transcriptome in response to abiotic stress. In: Plant Stress Tolerance, Series: Methods in   Molecular Biology, 639: 71-93, 2010. (24 times cited)
  • 17. G. Govind, V.T. Harshavardhan, J.T. Patricia, D.R. Iyer, M.S. Kumar, N. Sreenivasulu, M. Udayakumar. Identification and functional validation of a unique set of drought induced genes preferentially expressed in response to  gradual water stress in peanut. Molecular Genetics and Genomics, 281(6): 591-605, 2009.         (75 times cited)
  • 16. N. Sreenivasulu*, S.K. Sopory and P.B. Kavi Kishor. Deciphering the regulatory mechanisms of abiotic         stress tolerance in plants by genomic approaches. (Review article) Gene 388(1-2): 1-13, 2007. Pdf file                (268 times cited; Highly cited paper in the last 10 years from Gene Journal)  
  • 15. G.Jogeswar, N.M. Jakka, P.S. Reddy, K.R. Rao, J.V. Rao, N. Sreenivasulu and P.B. Kavi Kishor. Antioxidative response in different sorghum species under short-term salinity stress. Acta Physiologia Plantarum 28: 465-475, 2006.  Pdf file (33 times cited) 
  • 14. P. B. Kavi Kishor, S. Sangam, R. N. Amrutha, P. Sri Laxmi, K. R. Naidu, K. R. S. S. Rao, Sreenath Rao, K. J. Reddy, P. Theriappan and N. Sreenivasulu*. Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: Its implications in plant growth and abiotic stress tolerance. (Review article) Current Science 88(3): 424-438, 2005.   Pdf file (878 times cited; Highly cited paper in the last 10 years)
  • 13. S. Sangam, D. Jayasree, K.J. Reddy, P.V.B. Chari, N. Sreenivasulu, and P.B. Kavi Kishor. Salt tolerance in plants - transgenic approaches (Review article) Journal of Plant Biotechnology 7(1): 1-15, 2005.  Pdf file (12 times cited)
  • 12. N. Sreenivasulu, M. Miranda, H.S. Prakash, U. Wobus and W. Weschke. Transcriptome changes in foxtail millet genotypes at high salinity: Identification and characterization of a PHGPX gene specifically upregulated by NaCl in a salt-tolerant line Journal of Plant Physiology  161 (4):  467-477, 2004.   Pdf file (52 times cited) 
  • 11. N. Sreenivasulu, B. Grimm, U. Wobus and W. Weschke. Differential response of antioxidant compounds to salinity stress in salt-tolerant and salt-sensitive seedlings of foxtail millet (Setaria italaica). Physiologia plantarum 109: 435-442, 2000.  Pdf file (314 times cited)
  • 10. S. G. Kumar, K.V. Madhusudhan, N. Sreenivasulu and C. Sudhakar. Stress responses in two genotypes of mulberry (Morus alba L.) under NaCl salinity. Indian Journal of Experimental Biology 38: 192-195, 2000.  Pdf file (34 times cited)
  • 9. N. Sreenivasulu, S. Ramanjulu, K.R. Kini, H.S. Prakash, H.S. Shetty, H.S. Savithri and C. Sudhakar. Peroxidase activity and peroxidase isoforms as modified by salt stress in two cultivars of foxtail millet with differential salt tolerance.  Plant Science 141: 1-9, 1999.   Pdf file (135 times cited)
  • 8. S. Ramanjulu, N. Sreenivasulu, S. G. Kumar and C. Sudhakar. Photosynthetic characteristics in mulberry during water stress and rewatering. Photosynthetica 35(2):  259-263, 1998.   Pdf file (15 times cited) 
  • 7. S. Ramanjulu, N. Sreenivasulu and C. Sudhakar. Effect of Water stress on photosynthesis in two mulberry genotypes with differential drought tolerance. Photosynthetica 35(2): 279-283, 1998.   Pdf file (33 times cited)

III. Application of Bioinformatic Tools

  • 6. M. Lohse, A. Nunes-Nesi, P. Krüger, A. Nagel, J.Hannemann, F.M. Giorgi, L. Childs, S. Osorio-Algar, D. Walther, J. Selbig, N. Sreenivasulu, M. Stitt, A. R. Fernie, B. Usadel. Robin: An intuitive wizard application for R-based expression microarray quality assessment and analysis. Plant Physiology 153: 642-651, 2010.            (98 times cited)
  • 5. M. Strickert+, N. Sreenivasulu+, B. Usadel, U. Seiffert. Correlation-maximizing surrogate gene space for visual mining of gene expression patterns in developing barley endosperm tissue. BMC Bioinformatics 8: 165, 2007.  Pdf file (21 times cited
  • 4. B. Usadel, A. Nagel, D. Steinhauser, Y. Gibon, O.E. Bläsing, H. Redestig, N. Sreenivasulu, L. Krall, M.A.      Hannah, F. Poree, A.R. Fernie and  M. Stitt. PageMan an Interactive Ontology Tool to Generate, Display, and       Annotate Overview Graphs for Profiling Experiments. BMC Bioinformatics 7: 535, 2006.  Pdf file (210 times         cited)
  • 3. M. Strickert, N. Sreenivasulu, S. Peterek, W. Weschke, H-P. Mock and U. Seiffert. Unsupervised feature selection for biomarker identification in chromatography and gene expression data. Lecture Notes in Artificial Intelligence 4087: 274-285, 2006.  Pdf file (2 times cited)
  • 2. M. Strickert, U. Seiffert, N. Sreenivasulu, W. Weschke, T. Villmann and B. Hammer. Generalised Relevance LVQ (GRLVQ) with correlation measures for gene expression analysis. Neuro computing 69: 651-659, 2006.   Pdf file (35 times cited)
  • 1. M. Strickert, S. Teichmann, N. Sreenivasulu and U. Seiffert. High-throughput multidimensional scaling (HiT-MDS) for cDNA array expression data. Lecture notes in Computer Science 3696: 625-633, 2005. Pdf file (37 times cited)


Book Chapters

  • 1.  J.P. Matthews, S. Gemme, H-J. Huebschmann, C. Llorente, R. Jiminez, N. Sreenivasulu Metabolomics of rice genotypes using GC-MS/MS In: Aoolication note 10419 Thermo Scientific, pp. 1-9, 2014.


    2.  P.S. Reddy, V. Vandez,  N. Sreenivasulu and P.B. Kavi Kishor Tackling the heat-stress tolerance in crop plants: A bioinformatics approach. In: Agricultural Bioinformatics, Eds. P. B. Kavi Kishor et al., PP. 33-57, 2014.


    3.  M. Gils, N. Sreenivasulu and A. Graner. Molecular breeding for malting quality. In: Barley Chemistry and Technology, 2nd Edition. Eds: P.R. Shewry and S. Ullrich, AACCI Press, pp. 293-309, 2014.


    4.  P.B. Kavi Kishor, R. Kalladan, P.S. Reddy, C. Seiler and N. Sreenivasulu. Drought stress tolerance mechanisms in barley and its relevance to cereals. In: Biotechnology in Agriculture and Forestry. Eds: J. Kumlein and N. Stein, Springer, Heidelberg, pp. 161-179, 2014.


    5.  P.S. Reddy and N. Sreenivasulu Different Omics Approaches in Cereals and their Possible Implications for Developing a System Biology Approach to Study the Mechanism of Abiotic Stress Tolerance In: Cereal Genomics II, Eds. P. K. Gupta and R. K. Varshney, Springer, Heidelberg, pp. 177-214, 2013


    6.  H. Weber, N. Sreenivasulu and W. Weschke.The Molecular Physiology of Seed Maturation and Seed Storage Protein Biosynthesis. In: Plant Developmental Biology ­ Biotechnological Perspectives: Vol. 2, Eds.: Eng-Chong Pua and Michael Davey, Springer, Heidelberg, pp. 83-104, 2010.


    7.  N. Sreenivasulu, M. Röder and U. Wobus. Trockenstress – eine Suche nach den Ursachen und nach neuen Wegen zur Züchtung trockentoleranter Getreide. In: M. Arlt and D. Büssis (Eds) GENOMXPRESS. 4: pp. 4-6, 2010.


    8. U. Wobus, H.P. Mock, C. Pietsch, V. Radchuk, M. Röder, F. Schreiber, U. Seiffert,                      N. Sreenivasulu, M. Strickert, W. Weschke and K. Witzel. Barley as a model and a crop: Gene expression networks determining seed traits (GABI-SEED II). In: GABI – The German Plant Genome Research Program Progress Report 2004-2007. Published by GABI Managing office, Potsdam-Golm. pp. 76-83, 2008.


    9. M. Strickert, N. Sreenivasulu, T. Villmann and B. Hammer. Robust centroid-based clustering using derivatives of pearson correlation. In: P. Encarnacao and A. Veloso, editors, Proceedings of the 1st International Conference on Bio-inspired Systems and Signal Processing ‘BIOSIGNALS2008’ pp. 197-203, 2008.


    10. W. Weschke, H.P. Mock, C. Pietsch, V. Radchuk, M. Röder, F. Schreiber, U. Seiffert, N. Sreenivasulu, M. Strickert, and K. Witzel and U. Wobus. Genetical Genomics: der Gerstenkornentwicklung – von der Geexpression zu landwirtschaftlich bedeutsamen Merkmalen. In: J. Freitag (Ed) GENOMXPRESS. 1: pp. 12-16, 2007.


    11. U. Wobus, H.P. Mock, C. Pietsch, V. Radchuk, M. Röder, F. Schreiber, U. Seiffert,                     N. Sreenivasulu, M. Strickert, W. Weschke and K. Witzel. GABI-SEED: Genetische Grundlagen Komplexer agronomischer Merkmale im Getreidekorn entschlüsseln. In: J. Freitag (Ed) GENOMXPRESS 4: pp 19, 2006.


    12. U. Wobus and N. Sreenivasulu. Genomics approaches for the improvement of cereals. In: J. Freitag (Ed) European Training and Networking activity, Plant Genomics and Bioinformatics Expression Micro Arrays and Beyond- a course book. pp. 146-155. 2006.


    13. M. Strickert, N. Sreenivasulu and U. Seiffert. Sanger-driven MDSLocalize –A Comparative study for Genomic Data.  In. M. Verleysen, editor, Proceedings of the 14th European Symposium on Artificial Neural Networks ‘ESANN 2006’, Bruges, Belgium. D-Side publishers Evere/Belgium. pp. 265-270, 2006.


    14. U. Wobus, N. Sreenivasulu, L. Borisjuk, H. Rolletschek, R. Panitz, S. Gubatz and W. Weschke. Molecular physiology and genomics of developing barley grains. In: Recent Research Developments in Plant Molecular Biology 37/661 (2): pp. 1-29. 2005.


    15. M. Strickert, N. Sreenivasulu, W. Weschke, U. Seiffert, and T. Villmann. Generalized Relevance LVQ with Correlation Measures for Biological Data.  In. M. Verleysen, editor, Proceedings of the 13th European Symposium on Artificial Neural Networks ‘ESANN 2005’, Bruges, Belgium. D-Side publishers Evere/Belgium. pp. 331-338, 2005.


    16. M. Strickert, S. Teichmann, N. Sreenivasulu and U. Seiffert. DIPPP Online self-improving linear map for distance-preserving data analysis. In: M. Cottrell, editor, Proceedings of the 5th Workshop on Self-Organizing Maps ‘WSOM 2005’ pp.  661-668, 2005.


    17. W. Weschke, N. Sreenivasulu, V. Radchuk, S. Gubatz and U. Wobus. Functional genomics of barley seed development. In: GABI – The German Plant Genome Research Program Progress Report 1999-2004. Published by GABI Managing office, Potsdam-Golm. pp. 140-141. 2004.


    18. N. Sreenivasulu, R.K. Varshney, P.B. Kavi Kishor and W. Weschke. Tolerance to abiotic stress in cereals: A functional genomics approach. In: P.K. Gupta and R.K. Varshney (Eds) Cereal Genomics. Springer, Heidelberg, pp. 483-514, 2004.


    19. N. Sreenivasulu. Gene revolution during genomic era: its impact in dissecting the mechanisms of abiotic stress tolerance in plants. In: H. S. Prakash, S.R. Niranjana and R. Kini (Eds) Vistas in Applied Botany - Prof. H. Shekar Shetty's 60th birthday commemorative volume. pp. 161-177, 2004.


    20. E. Potokina, M. Caspers, N. Sreenivasulu, M. Wang, L. Altschmied and A. Graner. Functional Genomics of barley: Of the finding profit to the use. Vorträge für pflanzenzüchtung 54: 173-181, 2002.


    21. W. Weschke, N. Sreenivasulu, R. Panitz, H. Weber and U. Wobus. Interaction of maternal and filial tissues in the early development of the barley caryopsis: a cDNA Array analysis. Vorträge für pflanzenzüchtung 52: 69-74, 2001.


  • U. Hähnel, M. Siefken, N. Sreenivasulu and L. Altschmied. Transcription Profiling – beyond Simple Comparisons of two Situations. In: J. Collado-Vides, R. Hofestädt and C. Sense, editor: Integrative Bioinformatics – Aspects of the virtual cell. 2-3, 2006.
  • M. Lange, N. Sreenivasulu, A. Stephanik and U. Scholz. Data relationship mining in life science databases. In: R. Hofestädt , editior: International Workshop Integrative Bioinformatics- Complex Metabolic Networks. 9-11, 2005.
  • M. Lange, N. Sreenivasulu and U. Scholz. Automated EST annotation for a comparable functional gene expression study. Proceedings of the German Conference on Bioinformatics. 94-95, 2004.
  • N. Sreenivasulu, H. Zhang, V. Radchuk, U. Wobus and W. Weschke. In silico expression analysis of barley ESTs: Tissue-specificity of starch accumulation and mobilization. Proceedings of Barley Genetics IX. 374-380, 2004.
  • M.P.M. Caspers, E. Potokina, B.M.C. van der Vat, N. Sreenivasulu, A. Graner and M. Wang. Malting quality of barley cultivars in terms of gene expression. Proceedings of the VII ESA Congress of the European Society for Agronomy. 2002.
  • N. Sreenivasulu, L. Altschmied, V. Radchuk, R. Panitz, W. Weschke and U. Wobus. Chasing the dream: Genomic approaches to barley seed development. Proceedings of Seed Science and Technology in the New Millennium – Vistas and Vision 27-28, 2001.
  • N. Sreenivasulu, M. Miranda, L. Altschmied, U. Wobus and W. Weschke. Differential expression of protective antioxidant components to NaCl stress in foxtail millet genotypes. Proceedings of the 4th International Triticeae Symposium 399-403, 2001.
  • N. Sreenivasulu, M. Siefken, U. Hähnel, W. Weschke, U. Wobus and L. Altschmied. (Authors N.S and M.S are contributed equally) Multiparallel expression analysis using EST-Clones from Barley. Proceedings of Barley Genetics VII 196-198, 2000.

Invited speaker in International conferences

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List of posters presented in International conferences

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