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National Cycle Route 45 begins in the north at Chester where it leaves NCR 5 and heads south to Whichurch and then weaves its way around the Shropshire countryside via Shawbury to the east of Shrewsbury, The route crosses paths with National Cycle Route 81 at Upton Magna before making its way through Little Wenlock to Ironbridge, The route following the Mercian Way runs along the River Severn, It meets with National Cycle Route 55 at Jackfield, before passing through Coalport and continuing along the Severn on a mainly off road stretch to Bridgenorth. The route joins the roads again through Bridgnorth and continues along the roads to Hampton Loade, here it follows the River Severn and Severn Valley Steam Railway through Severn Valley Country Park to Alverley where the route crosses over the River Severn and joins the road network again. The route continues to Bewdley, crossing the Severn again and passing through Wyre Forest for a few miles of off road again. From Bewdley the route passes through the north of Stourport/South of Kidderminster where it meets with National Route 54 on the Staffordshire and Worcester Canal. NCR 45 then makes its way to Hartlebury before continuing to Droitwich Spa. From Droitwich its back over to the River Severn at Worcester where there route runs close to National Route 46, one each side of the River through the town. The route continues towards Tewksbury but is under development from near the M50/M5 junction to Tewksbury, but from Tewksbury the route can be found again where it runs further Southward to Gloucester where it joins NCR 41, picking up for a short section once again along the River Severn along the way. 

     HEADING NORTH:
  • Worcester to Droitwich
  • Droitwich to Hartlebury
  • Hartlebury to Bewdley
  • Bewdley to Alverley
  • Alverley to Bridgnorth
  • Bridgnorth to Ironbridge
  • Ironbridge to Upton Magna
     HEADING SOUTH:
  • Upton magna to Ironbridge
  • Ironbridge to Bridgnorth
  • Bridgnorth to Alverley
  • Alverley to Bewdley
  • Bewdley to Hartlebury
  • Hartlebury to Droitwich
  • Droitwich to Worcester