Nathan's new book has been published: In Silico Medicinal Chemistry.
Nathan has been appointed to the Scientific Advisory Board of Molomics.
Nathan is speaking at the Resources for Computational Drug Discovery 2014 at EBI, Cambridge.
Nathan has been appointed to the Editorial Board of Advances in Drug Discovery and Development.
Our recent paper on ligand-based and structure-based virtual screening was the number one most-read J. Chem. Inf. Model. last month.
We've just been to Strasbourg for the Summer School on Chemoinformatics. So many legends speaking!
New review article as part of the Mol. Inf. Strasbourg Summer School on Chemoinformatics is published.
We welcome Dr Michael Carter from the Essex group in Southampton to our group as a Postdoctoral Fellow.
Team in silico is on manoeuvres at ICCS 2014 in Noordwijkerhout. Come and say hello!
New paper from the group on using ligand similarity in improving significance of docking results.
Recent paper from the group selected as an F1000Prime.
Nath delivers invited lecture at the University of York.
Congratulations to Fabio on his move to Genentech!
New paper by Yi published in Journal of Chemical Information and Modeling on fragment space analysis.
nathan.brown [at] icr.ac.uk
Group Leader, In Silico Medicinal Chemistry
Cancer Research UK Cancer Therapeutics Unit
Division of Cancer Therapeutics
The Institute of Cancer Research, London, U.K.
I lead the In Silico Medicinal Chemistry group in the Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research in London, supporting Chemoinformatics, Molecular Modelling, Chemometrics, and Computational Chemistry within the Medicinal Chemistry department. My primary interests are in the development and application of software tools to push forward the progress of drug discovery with a particular focus on simultaneously optimising multiple objectives. At the ICR, our group supports the activities of over 50 PhD medicinal chemists spread over a number of teams and therapeutic areas working towards novel oncology therapeutics.
I have also recently conducted research at the Universities of Sheffield, UK and Erlangen-Nuremberg, Germany, and Eli Lilly & Co. in Ascot, UK, Avantium Technologies in Amsterdam, Netherlands, and most recently the Novartis Institutes for BioMedical Research in Basel, Switzerland.
I have a wide range of experience as a software designer and developer in many different programming languages. Using these skills I have developed a variety of novel algorithms and tools to maximise the impact of our experimental data. I have a particular interest in data visualisation using novel statistical and charting methods to disseminate information as appropriately as possible for the intended audience.
My primary interests are: virtual ligand docking, de novo molecular design, multi-objective optimisation, molecular descriptors, predictive modelling, graph theory, machine learning, evolutionary algorithms, molecular similarity and diversity, bioisosteric replacement, and scaffold hopping.
I currently review for Journal of Chemical Information and Modeling, Journal of Computer-Aided Molecular Design, Journal of Molecular Graphics and Modelling, Journal of Cheminformatics, QSAR and Combinatorial Science, Journal of Medicinal Chemistry, Nature Chemistry, Nature Protocols, Drug Discovery Today, Future Medicinal Chemistry, Medicinal Chemistry Communications, PLoS One, Bioorganic & Medicinal Chemistry, Regulatory Toxicology and Pharmacology, Dental Materials, Combinatorial Chemistry and High-Throughput Screening, and Chemical Engineering Science.
I sit on the committees of the UK QSAR and Chemoinformatics Group, and the Chemical Information and Computer Applications Group of The RSC. I am also on the Editorial Board of Advances in Drug Discovery and Development, and Frontiers in Chemistry: Theoretical and Computational Chemistry.
2007 - Present
2015 - Present
Member of the Scientific Advisory Board, Molomics, Barcelona, Spain.
2004 - 2007
2002 - 2004
Dr Nathan Brown MRSC ~ Group Leader, In Silico Medicinal Chemistry ~ Updated 3rd September 2015