Publications


 

Natarajan Ganesan, PhD MBA

  • Publications
  • Conference presentations
  • Invited talks/persentations
  • News Clippings

Publications

  • "Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon."; Natarajan TG,...Ganesan N et.al., (April 2010), Cancer Cell International, Vol. 10:13 [doi:10.1186/1475-2867-10-13]

  • "Bioinformatics and the race for the $1000 genome: How ready are the start ups." Biopreneur. September 2008, Vol 1, No:2, p 5-8. Natarajan Ganesan

  • "Disruption of transforming growth factor-ß signaling through ß-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation"; K Kitisin, N Ganesan, et.al., (2007), Oncogene, adv online publication - June 4th 2007[doi:10.1038/sj.onc.1210513].
  • "Hepatocellular cancer loses TGF-beta progenitor/stem cell niche, and is suppressed by cross talk between TGF-beta and IL-6 signaling pathways", K Kitisn, Y Tang, N Ganesan et.al., (Feb 2007), J Surgical Research, Vol 137, Issue 2, 268-269 [doi:10.1016/j.jss.2006.12.308 ]
  • "N-7-Alkyl-2'-Deoxyguanosine as Surrogate Biomarkers for N-Nitrosamine Exposure in Human Lung", Natarajan Ganesan, Shunji Kato, Elise D. Bowman, Peter G. Shields, Int. J. Can. Prev., (2007), Vol. 2, No. 4, pp. 265-277  
  • Bioinformatics Data Profiling Tools: A Prelude to Metabolic Profiling", Natarajan Ganesan*, Bala Kalayanasundaram, Mahe Velauthapillai; Pac Symp Biocomput. (2007), 12, 127-132
  • "Identification of human liver progenitor cell populations regulated by TGF-beta signaling that develop an altered phenotype in human hepatocellular cancers"; Ganesan N, Kitisin K et.al., (Oct 2006), Hepatology, 44(4): 474A-474A 766 Suppl  1 Oct 2006
  • "Transforming growth factor-beta (TGF-beta) signaling may play a protective role in preventing liver from insulin induced steatosis by regulating insulin driven AKT inactivation of forkhead transcriptional factor proteins", Kitisin K, Ganesan N et.al., J. American College of Surgeons, Volume 203, Issue 3, Supplement 1, September 2006, Pages S10-S11
  • "TGF beta Signaling in Gastrointestinal Stem Cells.", Science's STKE, (Connections Map, as seen September 2005), Krit Kitisin, Tiffany Blake, Yi Tang, Tapas Saha, Nady Golestaneh, Natarajan Ganesan, Lopa Mishra, http://stke.sciencemag.org/cgi/cm/stkecm;CMP_17699   AND 3 Peer reviewed pathway submissions 
  • "TGF-beta signaling is required for ductal progenitor cell differentiation...", Kitisin K, Ganesan N et.al., GASTROENTEROLOGY 130 (4): A539-A539 Suppl. 2, APR 2006, doi:10.1016/j.jss.2005.11.409    
  • "γ-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: Caffeine modulates the outcome of mutagen sensitivity assay"; Thanemozhi G. Natarajan, Natarajan Ganesan et. al., Cancer Epidemiology Biomarkers & Prevention 2006; 15(3). March 2006 
  • "Morphological changes of C.albicans in response to Cisplatin treatment: A fluorescence microscopy study using Ethidium bromide staining ", K. Chandrasekhar, R. Malathi and Natarajan Ganesan*; Ann Clin Microbiol Antimicrob. 2005 Apr 25;4(1):7 (Top 5 downloads May 2005)  
  • "Gold layer based dual crosslinking procedure of glucose oxidase with ferrocene monocarboxylic acid provides a stable biosensor", Natarajan Ganesan*, Anand P. Gadre, Makarand Paranjape, John F. Currie; 2005 Analytical Biochemistry 343(1), 188-191
  • "A web-based interface facilitating sequence to structure analysis of BLAST alignment reports", Natarajan Ganesan et.al. Biotechniques - 2005, Vol 39(2), pp 186-188
  • "SEQUEROME: A web based 'Sequence Profiling Tool' for genome and Proteome analysis"; Natarajan Ganesan, Nick Bennett et al., CBHD (online), Chapter 39. 
  • "Micro-System for Electrochemical Detection – Sensing Transdermally using an Array Technology", A.P. Gadre, Y. N. Srivastava, N. Ganesan, J. Holeman, J. F. Currie and M. Paranjape, MicroTAS 2004, 2, 398-400, Sep 2004. [doi: 10.1039/9781847551436]
  • "Polycarboxylates as drug delivery systems for anti-tumor Pt(II) complexes"; Natarajan Ganesan, Malathi Raghunathan & Eggehard Holler; Proc. Am. Assoc. Can. Res., March 2003, Vol. 44
    "Molecular mechanisms of carboplatin:DNA interactions and MCF-7 cell line toxicity studies provides possible new caveats"; Natarajan Ganesan, Malathi Raghunathan & Eggehard Holler; Proc. Am. Assoc. Can. Res, March 2003, Vol. 44.
  • “Enzymatic 14C-postlabeling using N-acetyltransferase as a biomarker tool: Extending the limits of detecting carcinogen-DNA adducts"; Natarajan Ganesan, Radoslav Goldman, Jayanta Kumar Mukhopadhyaya, Peter G. Shields; Proc. Am. Assoc. Can. Res, Vol. 43, March 2002.
    32P-labeling Assay of 7-Alkyl-2'-Deoxyguanosine Adducts In Human Lung Tissues: A Molecular Epidemiological Survey; Natarajan Ganesan, Shunji Kato, Stefano Petruzzelli, Elise D. Bowman, Peter G. Shields; Proc. Am. Assoc. Can. Res, Vol. 42, March 2001.
  • "Increased DNA-binding activity of cis-1,1-cyclobutane dicarboxylato diammine platinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited"; G. Natarajan, R. Malathi & Eggehard Holler, Biochem. Pharmacol. (1999) Nov 15; 58 (10): 1625-9.
  • "Tumor inhibiting and DNA binding properties of a platinum complex coupled to a bioresorbable polymer" G. Natarajan, R.Malathi and Eggehard Holler,(1998) MACROMOLECULES NEW FRONTIERS, Ed. K.S.V.Srinivasan, ISBN 81-7023-760-2 Allied Publishers Ltd., New Delhi, vol. II, p600-602,
  • "Helix-coil transitions in DNA modified by novel Pt (II) complexes: A pH melting study" G. Natarajan, R.Malathi & Eggehard Holler (1998), J. Biomol. Str. Dyn., 15(No:6), 1173-1180
    “Helix-coil transition studies in DNA using pH variation method: Case of a melting paradox as a function of ionic strength" G. Natarajan, R.Malathi & Eggehard Holler (1996), Anal. Biochem., 237, 152-155.[
    doi: 10.1006/abio.1996.0216

Conference poster/abstract presentations (including oral)

  • "Race influences access to liver transplantation and mortality on waiting list"; Omar Khokhar, Natarajan Ganesan, Lynt Johnson and Kirti Shetty, Oral Session- Clinical-, AASLD topic forum on Liver transplantation, Digestive Diseases Week 2006, LA California
  • "TGF-beta signaling is required for ductal progenitor cell diffrentiation....", Krit Kitisin, Natarajan Ganesan, Yi Tang et.al., T-1674, Digestive Diseases Week 2006, LA   
    "Molecular and structural aspects of ELF and other TGF-beta pathway components: Role in HCC and Cholangiocarcinoma", Ganesan N., Kitisin K., Tang Y., Katuri V, Jogunoori W., Mishra B., Shetty K., Mishra L., Johnson L., AACR special conference on TGF-ß in Cancer and other diseases, Feb 2006
  • "TGF-β Signaling Pathway Inactivation and Cell Cycle Deregulation in Human Hepatocellular Cancer Cell Lines and elf+/- Tissues", K. Kitisin, N. Ganesan., E. Volpe, S. S. Kim, W. Jogunoori, Y. Tang, V. Katuri, K. Shetty, B. Mishra, L. Mishra, L. Johnson, Annual Academic Surgical Congress, San Diego, Feb 2006
  • "The Influence of Race on Access to Liver Transplantation and Waiting-List Mortality"; Khokhar O, Ganesan N, Mishra LM, Johnson LB, Shetty K., AASLD Liver meeting 2005.   
  • "Fabrication of a Multi Polymeric Bio-Integerable Transdermal Sampling Deivce", A.P. Gadre, Y.N. Srivastava, N. Ganesan, M. Paranjape and J.F.Currie, MEMS in Homeland Security, Defense and Aerospace applications, Spring 2004
  • "Molecular epidemiology of Breast Cancer: Development and validation of acetylation methods for carcinogen adduct detection", Peter G. Shields, K. Turteltaub,  Goldman R., and Natarajan Ganesan, ‘Era of Hope’ DOD breast cancer research meeting, Sep 25th-28th 2002.
  • "Is Carboplatin activated before reaching its target sequences? ", G. Natarajan, R. Malathi & Eggehard Holler, 11th conversation in Biomolecular Structure and Dynamics;, June 1998.
    "Selective uptake of white adipose tissue fatty acids during negative energy balance: a novel mathematical approach", Natarajan Ganesan,  XVI International Congress of Biochemistry and Molecular Biology (New Delhi, Sept 19-22, 1994).

Invited Talks/presentation

  • "Bioelectrochemical approaches to ELISA development methodology", Inst. of Basic Medical Sciences, Univ. of Madras, Taramani 600113, 13th Sep 2004
  • “Potential application of transdermal biochips for remote sensing by voltammetric techniques” Minisymposium on Biophysics, December 15 2003, Georgetown University, Washington DC - 20057
  • "Biophysical Methods in Structural Biology: Cancer Therapy to Biomakers and Biosensors",  Colloquium at the Computer Science Dept., 26 Sept 2003, 261A Reiss Science Bldg, Georgetown Univ., Washington DC - 20057 
  • "Cross-linking Platinum(II) compounds as tool in RNA folding studies", Dept. of Chemistry & Biochemistry, Univ. of Maryland - Baltimore Campus, 25th Nov 2001, Baltimore MD - 21250
    "Molecular aspects DNA binding anti-cancer platinum (II) complexes", Lombardi Cancer Center, 25th Jan 2000, Washington DC - 20007

News Clippings