Natarajan Ganesan, PhD MBA

  • Publications
  • Conference presentations
  • Invited talks/persentations
  • News Clippings


  • "Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon."; Natarajan TG,...Ganesan N, (April 2010), Cancer Cell International, Vol. 10:13 [doi:10.1186/1475-2867-10-13]

  • "Bioinformatics and the race for the $1000 genome: How ready are the start ups." Biopreneur. September 2008, Vol 1, No:2, p 5-8. Natarajan Ganesan

  • "Disruption of transforming growth factor-ß signaling through ß-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation"; K Kitisin, N Ganesan,, (2007), Oncogene, adv online publication - June 4th 2007[doi:10.1038/sj.onc.1210513].
  • "Hepatocellular cancer loses TGF-beta progenitor/stem cell niche, and is suppressed by cross talk between TGF-beta and IL-6 signaling pathways", K Kitisn, Y Tang, N Ganesan, (Feb 2007), J Surgical Research, Vol 137, Issue 2, 268-269 [doi:10.1016/j.jss.2006.12.308 ]
  • "N-7-Alkyl-2'-Deoxyguanosine as Surrogate Biomarkers for N-Nitrosamine Exposure in Human Lung", Natarajan Ganesan, Shunji Kato, Elise D. Bowman, Peter G. Shields, Int. J. Can. Prev., (2007), Vol. 2, No. 4, pp. 265-277  
  • Bioinformatics Data Profiling Tools: A Prelude to Metabolic Profiling", Natarajan Ganesan*, Bala Kalayanasundaram, Mahe Velauthapillai; Pac Symp Biocomput. (2007), 12, 127-132
  • "Identification of human liver progenitor cell populations regulated by TGF-beta signaling that develop an altered phenotype in human hepatocellular cancers"; Ganesan N, Kitisin K, (Oct 2006), Hepatology, 44(4): 474A-474A 766 Suppl  1 Oct 2006
  • "Transforming growth factor-beta (TGF-beta) signaling may play a protective role in preventing liver from insulin induced steatosis by regulating insulin driven AKT inactivation of forkhead transcriptional factor proteins", Kitisin K, Ganesan N, J. American College of Surgeons, Volume 203, Issue 3, Supplement 1, September 2006, Pages S10-S11
  • "TGF beta Signaling in Gastrointestinal Stem Cells.", Science's STKE, (Connections Map, as seen September 2005), Krit Kitisin, Tiffany Blake, Yi Tang, Tapas Saha, Nady Golestaneh, Natarajan Ganesan, Lopa Mishra,;CMP_17699   AND 3 Peer reviewed pathway submissions 
  • "TGF-beta signaling is required for ductal progenitor cell differentiation...", Kitisin K, Ganesan N, GASTROENTEROLOGY 130 (4): A539-A539 Suppl. 2, APR 2006, doi:10.1016/j.jss.2005.11.409    
  • "γ-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: Caffeine modulates the outcome of mutagen sensitivity assay"; Thanemozhi G. Natarajan, Natarajan Ganesan et. al., Cancer Epidemiology Biomarkers & Prevention 2006; 15(3). March 2006 
  • "Morphological changes of C.albicans in response to Cisplatin treatment: A fluorescence microscopy study using Ethidium bromide staining ", K. Chandrasekhar, R. Malathi and Natarajan Ganesan*; Ann Clin Microbiol Antimicrob. 2005 Apr 25;4(1):7 (Top 5 downloads May 2005)  
  • "Gold layer based dual crosslinking procedure of glucose oxidase with ferrocene monocarboxylic acid provides a stable biosensor", Natarajan Ganesan*, Anand P. Gadre, Makarand Paranjape, John F. Currie; 2005 Analytical Biochemistry 343(1), 188-191
  • "A web-based interface facilitating sequence to structure analysis of BLAST alignment reports", Natarajan Ganesan Biotechniques - 2005, Vol 39(2), pp 186-188
  • "SEQUEROME: A web based 'Sequence Profiling Tool' for genome and Proteome analysis"; Natarajan Ganesan, Nick Bennett et al., CBHD (online), Chapter 39. 
  • "Micro-System for Electrochemical Detection – Sensing Transdermally using an Array Technology", A.P. Gadre, Y. N. Srivastava, N. Ganesan, J. Holeman, J. F. Currie and M. Paranjape, MicroTAS 2004, 2, 398-400, Sep 2004. [doi: 10.1039/9781847551436]
  • "Polycarboxylates as drug delivery systems for anti-tumor Pt(II) complexes"; Natarajan Ganesan, Malathi Raghunathan & Eggehard Holler; Proc. Am. Assoc. Can. Res., March 2003, Vol. 44
    "Molecular mechanisms of carboplatin:DNA interactions and MCF-7 cell line toxicity studies provides possible new caveats"; Natarajan Ganesan, Malathi Raghunathan & Eggehard Holler; Proc. Am. Assoc. Can. Res, March 2003, Vol. 44.
  • “Enzymatic 14C-postlabeling using N-acetyltransferase as a biomarker tool: Extending the limits of detecting carcinogen-DNA adducts"; Natarajan Ganesan, Radoslav Goldman, Jayanta Kumar Mukhopadhyaya, Peter G. Shields; Proc. Am. Assoc. Can. Res, Vol. 43, March 2002.
    32P-labeling Assay of 7-Alkyl-2'-Deoxyguanosine Adducts In Human Lung Tissues: A Molecular Epidemiological Survey; Natarajan Ganesan, Shunji Kato, Stefano Petruzzelli, Elise D. Bowman, Peter G. Shields; Proc. Am. Assoc. Can. Res, Vol. 42, March 2001.
  • "Increased DNA-binding activity of cis-1,1-cyclobutane dicarboxylato diammine platinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited"; G. Natarajan, R. Malathi & Eggehard Holler, Biochem. Pharmacol. (1999) Nov 15; 58 (10): 1625-9.
  • "Tumor inhibiting and DNA binding properties of a platinum complex coupled to a bioresorbable polymer" G. Natarajan, R.Malathi and Eggehard Holler,(1998) MACROMOLECULES NEW FRONTIERS, Ed. K.S.V.Srinivasan, ISBN 81-7023-760-2 Allied Publishers Ltd., New Delhi, vol. II, p600-602,
  • "Helix-coil transitions in DNA modified by novel Pt (II) complexes: A pH melting study" G. Natarajan, R.Malathi & Eggehard Holler (1998), J. Biomol. Str. Dyn., 15(No:6), 1173-1180
    “Helix-coil transition studies in DNA using pH variation method: Case of a melting paradox as a function of ionic strength" G. Natarajan, R.Malathi & Eggehard Holler (1996), Anal. Biochem., 237, 152-155.[
    doi: 10.1006/abio.1996.0216

Conference poster/abstract presentations (including oral)

  • "Race influences access to liver transplantation and mortality on waiting list"; Omar Khokhar, Natarajan Ganesan, Lynt Johnson and Kirti Shetty, Oral Session- Clinical-, AASLD topic forum on Liver transplantation, Digestive Diseases Week 2006, LA California
  • "TGF-beta signaling is required for ductal progenitor cell diffrentiation....", Krit Kitisin, Natarajan Ganesan, Yi Tang, T-1674, Digestive Diseases Week 2006, LA   
    "Molecular and structural aspects of ELF and other TGF-beta pathway components: Role in HCC and Cholangiocarcinoma", Ganesan N., Kitisin K., Tang Y., Katuri V, Jogunoori W., Mishra B., Shetty K., Mishra L., Johnson L., AACR special conference on TGF-ß in Cancer and other diseases, Feb 2006
  • "TGF-β Signaling Pathway Inactivation and Cell Cycle Deregulation in Human Hepatocellular Cancer Cell Lines and elf+/- Tissues", K. Kitisin, N. Ganesan., E. Volpe, S. S. Kim, W. Jogunoori, Y. Tang, V. Katuri, K. Shetty, B. Mishra, L. Mishra, L. Johnson, Annual Academic Surgical Congress, San Diego, Feb 2006
  • "The Influence of Race on Access to Liver Transplantation and Waiting-List Mortality"; Khokhar O, Ganesan N, Mishra LM, Johnson LB, Shetty K., AASLD Liver meeting 2005.   
  • "Fabrication of a Multi Polymeric Bio-Integerable Transdermal Sampling Deivce", A.P. Gadre, Y.N. Srivastava, N. Ganesan, M. Paranjape and J.F.Currie, MEMS in Homeland Security, Defense and Aerospace applications, Spring 2004
  • "Molecular epidemiology of Breast Cancer: Development and validation of acetylation methods for carcinogen adduct detection", Peter G. Shields, K. Turteltaub,  Goldman R., and Natarajan Ganesan, ‘Era of Hope’ DOD breast cancer research meeting, Sep 25th-28th 2002.
  • "Is Carboplatin activated before reaching its target sequences? ", G. Natarajan, R. Malathi & Eggehard Holler, 11th conversation in Biomolecular Structure and Dynamics;, June 1998.
    "Selective uptake of white adipose tissue fatty acids during negative energy balance: a novel mathematical approach", Natarajan Ganesan,  XVI International Congress of Biochemistry and Molecular Biology (New Delhi, Sept 19-22, 1994).

Invited Talks/presentation

  • "Bioelectrochemical approaches to ELISA development methodology", Inst. of Basic Medical Sciences, Univ. of Madras, Taramani 600113, 13th Sep 2004
  • “Potential application of transdermal biochips for remote sensing by voltammetric techniques” Minisymposium on Biophysics, December 15 2003, Georgetown University, Washington DC - 20057
  • "Biophysical Methods in Structural Biology: Cancer Therapy to Biomakers and Biosensors",  Colloquium at the Computer Science Dept., 26 Sept 2003, 261A Reiss Science Bldg, Georgetown Univ., Washington DC - 20057 
  • "Cross-linking Platinum(II) compounds as tool in RNA folding studies", Dept. of Chemistry & Biochemistry, Univ. of Maryland - Baltimore Campus, 25th Nov 2001, Baltimore MD - 21250
    "Molecular aspects DNA binding anti-cancer platinum (II) complexes", Lombardi Cancer Center, 25th Jan 2000, Washington DC - 20007

News Clippings