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Project overview

Project title: Designing new, flexible and low-cost paper-based sensing nanoplatforms through plasmonic calligraphy for multiplexed ultrasensitive detection of cancer biomarkers
Project Code: PN-III-P1-1.1-TE-2016-2095
Contract No.: 82 from 02/05/2018
Budget: ~99.000 EURO
Financing: Romanian National Authority for Scientific Research, UEFISCDI.
Program from PN IIIHuman Resources
Period: May 2018-Avril 2020
Intitution: Centerfor Nanobiophotonics and Laser Microspectroscopy, Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University
Project Leader: CS I Dr Monica Focsan

Project Summary:
The project “Designing new, flexible and low cost paper-based sensing nanoplatforms through plasmonic calligraphy for performing multiplexed ultrasensitive detection of cancer biomarkers” proposes the development of a new and inexpensive dual Localized Surface Plasmon Resonance - Surface Enhanced Raman Scattering (LSPR-SERS) nanosensor with multiplex capability within a miniaturized portable sensing paper-based nanoplatform for the detection of multiple specific targets on the same substrate. Specifically, to perform the selective and multiple biomarker detection using our chip, different active plasmonic lines will be fabricated via a simple plasmonic calligraphy approach using a commercial pen filled with plasmonic gold nanoparticles (i.e gold bipyramids and gold nanorods) as ink. The priority targeted biomarkers chosen to validate our nanosensors are the followings: anti-IgG, Cancer antigen (CA-125) and carcinoembryonic antigen (CEA) biomarkers. This project represents a real challenge with promising results for medical diagnostics, allowing the development of innovative plasmonic multiplex paper–based point-of-care biochip.