Project title: Designing new, flexible and low-cost
paper-based sensing nanoplatforms through plasmonic calligraphy for
multiplexed ultrasensitive detection of cancer biomarkers Project Code: PN-III-P1-1.1-TE-2016-2095 Contract No.: 82 from
02/05/2018 Budget: ~99.000 EURO Financing: Romanian National Authority for Scientific
Research, UEFISCDI. Program from PN III: Human Resources Period: May 2018-Avril 2020 Intitution: Center
for Nanobiophotonics and Laser Microspectroscopy, Interdisciplinary
Research Institute in Bio-Nano-Sciences, Babes-Bolyai
University Project Leader: CS I Dr Monica
Focsan
Project Summary: The
project “Designing new, flexible and low cost paper-based sensing nanoplatforms
through plasmonic calligraphy for performing multiplexed ultrasensitive
detection of cancer biomarkers” proposes the development of a new and
inexpensive dual Localized Surface Plasmon Resonance - Surface Enhanced Raman
Scattering (LSPR-SERS) nanosensor with multiplex capability within a
miniaturized portable sensing paper-based nanoplatform for the detection of
multiple specific targets on the same substrate. Specifically, to perform the
selective and multiple biomarker detection using our chip, different active
plasmonic lines will be fabricated via a simple plasmonic calligraphy approach
using a commercial pen filled with plasmonic gold nanoparticles (i.e gold
bipyramids and gold nanorods) as ink. The priority targeted biomarkers chosen
to validate our nanosensors are the followings: anti-IgG, Cancer antigen
(CA-125) and carcinoembryonic antigen (CEA) biomarkers. This project represents
a real challenge with promising results for medical diagnostics, allowing the
development of innovative plasmonic multiplex paper–based point-of-care biochip.
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