Nadya Markova

Associate Professor, Institute of Microbiology, Bulgarian Academy of Sciences

Academic Degrees      

PhD, Bulgarian Academy of Sciences;
MD, Pleven Medical University, Bulgaria

Departmental Address

Department of Pathogenic Bacteria
Institute of Microbiology, Bulgarian Academy of Sciences
26 G.Bonchev Street, 1113 Sofia, Bulgaria
Phone: +359 2 9793168

Main Fields of Interest

Medical Microbiology and Immunology

Infectious Diseases

Chemo and Immunotherapy

Immunomodulators and Vaccines

Professional Experience and Current Research Interest

1. Bacterial pathogenicity and virulence

2. Bacteria-host interaction, host response mechanisms

3. Bacterial L-forms, mechanisms of formation and persistence

4. Tuberculosis:

mycobacterial pathogenesis
mechanisms of dormancy and persistence
mycobacterial L-forms

5. Mechanisms of action of immunomodulator Lentinan

Interview with Nadya Markova:


Selected Publications:

Markova N.*, Slavchev G., Michailova L . Unique biological properties of Mycobacterium
tuberculosis L-form variants: impact for survival under stress. International Microbiology. 2012, 15:61-68. DOI: 10.2436/20.1501.01.159 ISSN: 1139-6709

Markova N. Cell Wall Deficiency in Mycobacteria: Latency and Persistence.   Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli, edited by Pere-Joan Cardona , InTech, 2012, pp. 193-216, ISBN 978-953-307-946-2.

Markova N.*, Slavchev G, Michailova L . Filterable forms and L-forms of Mycobacterium bovis BCG: impact for live vaccine features. Human Vaccines & Immunotherapeutics. 2012, 8 (6): 759 - 764.

Markova N.*, Slavchev G, Michailova L, Jourdanova M. Survival of Escherichia coli under lethal heat stress by L-form conversion. Int. J. Biol. Sci. 2010; 6:303-315. ISSN 1916-968X (Online)

Markova N.* Hidden face of tuberculosis. Bioscience Hypothesis. 2009, 2 (2):441-442. ISSN: 1756-2392.

Markova N., Michailova L., Jourdanova M., Kussovski V., Valcheva V., Mokrousov I., T Radoucheva T. (2008) Exhibition of persistent and drug-tolerant L-form habit of Mycobacterium tuberculosis. Central European Journal of Biololy 3(4) : 407–416.
Read abstract.

Markova N., Michailova L., Kussovski V., Jourdanova M. (2008) Formation of Persisting Cell Wall Deficient Forms of Mycobacterium bovis BCG during Interaction with Peritoneal Macrophages in Guinea Pigs. Electronic Journal of Biology. Vol.4(1): 1-10.

Markova N., Haydoushka I., Michailova L., Ivanova R., Valcheva V., Jourdanova M., Popova T., Radoucheva T. (2008) Cell wall deficiency and its effect on methicillin heteroresistance in Staphylococcus aureus. International Journal of Antimicrobial Agents. 31: 255-60. Abstract

Valcheva V., Mokrousov I., Narvskaya O., Rastogi N., Markova N. (2008) Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria. Infection Genetic and Evolution 8:657-63.

Valcheva V., Mokrousov I., Narvskaya O., Rastogi N., Markova N. (2008). Utility of New 24-locus VNTR typing for discriminating Mycobacterium tuberculosis clinical isolates in Bulgaria. J. Clin. Microbiol. 46: 3005-11.

Valcheva V., Mokrousov I., Narvskaya O., Rastogi N., Markova N. (2008) Molecular characterization of Mycobacterium tuberculosis isolates from different regions of Bulgaria. J. Clin. Microbiol. 46:1014-8.

Michailova L., Kussovski V., Radoucheva T., Jordanova M., Markova N.(2007) Persistence of Staphylococcus aureus L-form during experimental lung infection in rats. FEMS Microbiol Lett 268:88-97.

Michailova L ., Kussovski, V., Radoucheva, T., Jordanova M., Berger W., Rinder H., Markova N. (2005). Morphological variability and cell wall deficiency in Mycobacterium tuberculosis ‘heteroresistant’ stains. The Int. J. Tuberc.Lung. Dis. 9: 907-914.

Markova N., Michailova L., Kussovski V., Jourdanova M., Radoucheva T. (2005) Intranasal application of lentinan enhances bactericidal activity of rat alveolar macrophages against Mycobacterium tuberculosis. Pharmazie. 60 :42-8

Drandarska I., Kussovski V., Nikolaeva S., Markova N. (2005) Combined immunomodulating effects of BCG and Lentinan after intranasal application in guinea pigs. Int Immunopharmacol. 5:795-803.

Markova, N., V.Kussovski, I.Drandarska, S.Nikolaeva, T.Radoucheva, N.Georgieva (2003) Protective activity of Lentinan in experimental tuberculosis. Int. Immunopharmacology, 3: 1557-1562.

Markova, N., V.Kussovski, T.Radoucheva, K.Dilova, N.Georgieva. (2002) Effects of intraperitoneal and intranasal application of Lentinan on cellular response in rats. Int. Immunopharmacology, 2:1641-1645.

Markova N. (2001) Drug resistant tuberculosis. (Review) Infectology 38 :35-36.

Michailova, L, N.Markova, T Radoucheva, S.Stoitsova, V.Kussovski, M.Jordanova. (2000)
Atypical behaviour and survival of Steptococcus pyogenes L-forms during intraperitoneal infection in rats. FEMS Immunology and Medical Microbiology 28 :55-65.

Michailova, L., S. Stoitsova, N.Markova, T. Radoucheva, V.Kussovski, M. Jordanova, I.Dimova. (2000) Interaction of alveolar macrophages with Staphylococcus aureus and induction of microbial L-forms during infection in rats. Int. J. Med. Microbiol. 290:259-267.

Markova N., T. Radoucheva V. Kussovski, K. Dilova, I.Paskaleva, K.Veleva.(1999) Persistence and in vivo effects of Y.enterocolitica 0:3 endotoxin in rats. FEMS Immunology and Medical Microbiology 24:395-403.

Markova N., L. Mihailova L, A. Vesselinova , V. Kussovski , T. Radoucheva , S. Nikolova , I. Paskaleva . (1997) Cell wall deficient forms (L-forms) of Listeria monocytogenes in experimentally infected rats. Zbl.Bakt. 286: 46-55.

Mihailova,L. N. Markova, T.Radoucheva, D. Veljanov, S.Radoevska.(1993) Cell interaction of Listeria monocytogenes L-forms and peritoneal exudative cells in rats. Can. J. Microbiol. 39: 1014-1021.