Neuropsychology and Applied Cognitive Neuroscience (NACN) Lab 


Updated on Feb 4, 2009

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Raymond C K Chan, Ph.D. (HK)

Professor of Neuropsychology and Applied Cognitive Neuroscience
Institute of Psychology
Chinese Academy of Sciences
4A Datun Road
Beijing 100101
China
Tel: +86(0)10 64836274
Fax: +86(0)10 64836274
Email: rckchan@psych.ac.cn or rckchan2003@yahoo.com.hk
Webpage in CAS: http://www.psych.ac.cn

Research Interest

  • Study of neuropsychological performance (attention and executive function in particular) and everyday life cognitive errors in normal, sub-clinical and clinical populations (e.g., schizotypal personality, mild cognitive impairment, patients with schizophrenia, head trauma, frontal lobe lesions, and ADHD)
  • Application of social cognitive neuroscience (social psychology, cognitive sciences, neuropsychology) to the development of clinical assessment and intervention for patients with cognitive impairments (e.g., social cognition training in schizophrenia and schizotypy)
  • Developmental psychopathology
  • Measurement issues in clinical practice (e.g., development and validation of ecological valid test of neuropsychological performance, and articulating the laboratory-based test results to everyday life performance)
  • Coping and quality of life of patients with neurological and cognitive disorders

Paradigms

Neuropsychological Assessment

  • Neuropsychological assessment examines how the onset of neurological trauma or the course of psychosis affects neurological processes of the brain and mental, emotional and behavioural states. In effect, it is a mixture of neuroscience, cognitive psychology, and neuropsychology. This methodology can reveal information about the subject's current intellectual functioning, areas of cognitive strength, specific type of cognitive disorder and comparative standing with others of the same age or diagnostic group.
  • Recent emphasis has been paid on the integration of social psychology component into the development of more socially appropriate, ecologically and ethologically valid tests of neuropsychological performance. We are actively validating and developing new assessment tools for use in the context of Chinese clinical settings. 
  • We also adopt animal models to investigate the psychopathological deficits psychiatric diseases.

Neurophysiology and Imaging

  • Event-related Potential (ERP) paradigm is adopted for healthy, sub-clinical and clinical groups. Structural and functional MRI scans and eye-tracking machines are available locally for research purposes.

Molecular Biology and Behavioural Genetics

  • We are particularly interested in finding any optimal endophenotypical markers for Chinese patients with schizophrenia spectrum disorders, autistic spectrum disorders and ADHD

Social Cognition Intervention

  • We adopt this approach in order to study social functioning deficits and its related psychosocial impacts upon patients with schizophrenia spectrum disorders and other psychiatric populations

Peer-reviewed

Editorial board, Clinical Rehabilitation (2000 - 2007; being editorial advisor from 2007 onwards), Neuropsychological Rehabilitation (2004- present), Hong Kong Journal of Psychiatry (2003 – 2005), Advances in Psychological Science (Chinese) (2006 – present)

Ad Hoc reviewer , American Journal of Medical Genetics Part B: Neuropsychiatric Disorders (2006,2007); Archives of Clinical and Neuropsychology (2006,2007); Archives of General Psychiatry (2006); Biological Psychiatry (2006-2008); Brain and Cognition (2004--2006, 2008); Brain Research (2007-2008); Cortex (2006,2007); Disability and Rehabilitation (2001, 2004); European Archives of Psychiatry and Clinical Neurosciences (2008); Journal of the International Neuropsychological Society (2002--2008); Neurocase (2007); Neuropsychologia (2005--2007); Neuropsychology (2005, 2006); Neuropsychology Review (2008); Neuroscience Letters (2006); Schizophrenia Research (2006-2008)

Selected Publications

Chan, R. C. K.*, Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a northern star? Neuroscience and Biobehavioral Reviews,32(5), 957-971

Chan, R. C. K.*, Shum, D., Toulopoulou, T., Chen, E. Y. H. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201-216.

Chan, R. C.K*., Wang, Y., Ma, Z., Hong, X., Yuan, Y., Yu, X., Li, Z., Shum, D., & Gong, Q. (2008). Objective measures of prospective memory do not correlate with subjective complaints in schizophrenia. Schizophrenia Research, 103, 229-239.

Rao, H*., Di, X., Chan, R. C. K.*, Ding, Y., Ye, B., Gao, D. (2008). A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: evidence from functional connectivity analysis. NeuroImage, 41, 1345-1351.

Chan, R. C. K.*, Chen, E. Y. H.  (2007) Neurological abnormalities in Chinese patients with schizpohrenia. Behavioural Neurology, 18(3), 171-181.

 Wang, Y., Chan, R. C. K.*, Hong, X., Ma, Z., Yang, T., Guo, L., Yu, X., Li, Z., Yuan, Y., Gong, Q., & Shum, D. (2008). Prospective memory in schizophrena: Further clarification of nature of impairment. Schizophrenia Research, 105, 114-124.

Yang, B., Chan, R. C. K.*, Jing, J., Li, T., Sham, P., Chen, R. Y. L. (2007) A meta-analysis of association studies between the dopamine transporter gene and attention deficit hyperactivity disorder. American Journal of Medical Genetics Part B Neuropsychiatric Genetics , 144B(4), 541-550.

Chan, R. C. K., Guo, M., Zou, X., Li, D., Hu, Z., & Yang, B. (2006). Multitasking performance of Chinese children with ADHD. Journal of the International Neuropsychological Society, 12, 575-579.

Chan, R. C. K., Rao, H. Y., Chen, E. Y. H., Ye, B. B., & Zhang, C. (2006). The neural basis of motor coordination soft signs: an fMRI study of healthy subjects. Neuroscience Letter, 398, 189-194.

Honer, W. G., Thornton, A. E., Chen, E. Y. H., Chan, R. C. K., Wong, J. O. Y., Bergmann, A., Falkai, P., Pomarol-Clotet, E., Mckenna, P. J., Stip, E., Willaims, R., MacEwan, G. W., Wasan, K., Procyshyn, R. (2006). A randomized controlled trial of antipsychotic polypharmacy: risperidone versus placebo augmentation of clozapine in refractory schizophrenia. New England Journal of Medicine, 354, 474-482.

Chan, R. C. K., Chen, E. Y. H., & Law, C. W. (2006). Specific executive dysfunction in patients with first-episode medication-naïve schizophrenia. Schizophrenia Research, 82(1), 51-64

Chan, R. C. K., Chen, E. Y. H., Cheung, E. F. C., Chen, R. Y. L., & Cheung, H. K. (2006) The components of executive functioning in a cohort of patients with chronic schizophrenia: a multiple single-case study design. Schizophrenia Research, 81(2-3), 173-189

Chan, R. C. K., Chen, R. Y. L., Chen, E.  Y. H., Hui, T. C. K., Cheung, E. F. C., Cheung, H. K., Sham, P., Li, T., & Collier, D. (2005). The differential clinical and neurocognitive profiles of COMTSNPrs165599 in schizophrenia. Journal of the International Neuropsychological Society, 11, 202-204

Chan, R. C. K. (2005) How severe should symptoms be before we say someone is suffering from postconcussion syndrome? An exploratory study with self-reported checklist using Rasch Analysis. Brain Injury, 19(13), 1117-1124

Chan, R. C. K. (2002). Attentional deficits in patients with persisting postconcussive complaints: general deficit or specific component deficits? Journal of Clinical and Experimental Neuropsychology,24(8), 1081-1093

Chan, R. C. K. (2001). Dysexecutive symptoms among the non-clinical sample: a study with the use of the Dysexecutive Questionnaire. British Journal of Psychology, 92(3), 551-565

Chan, R. C. K. (2001). Base-rate of postconcussion symptoms among non-clinical sample and its neuropsychological correlates. Clinical Rehabilitation, 15(3), 266-273

Chan, R. C. K. (2000). Attentional deficits in patients with closed head injuries: a further study to the discriminative validity of the Test of Everyday Attention. Brain Injury, 14(3), 227-236.