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PGE2 Receptor Subtypes

Work in this part of the lab focuses on experimental research that investigates the contribution of PGE2 receptor subtypes to processes of neurodegeneration. 
Experimental investigations for this part of the lab focus on the role of prostaglandin E2 receptor subtypes (EP) in the brain's immune activation and paracrine damage to neurons.  We have made important discoveries about control of microglial activation by EP2 and protection from neurotoxicity by suppressing EP1 signaling.  Results from these studies have forged collaborations with industry partners to develop selective EP subtype antagonists.  Current work is addressing the signaling mechanims involved in an effort to identify more specific therapeutic targets.