Highlight:  Just published in Science Translational Medicine- "Dietary therapy mitigates persistent wake deficits in mild traumatic brain injury".   Abstract.

Research


    Our laboratory studies the neurobiological cascade of events following mild traumatic brain injury (TBI), with the goal of identifying novel pathways for therapeutics.
    We are particularly interested in injury-induced physiological changes using EEG analyses of sleep-wake rhythms. EEG is not only a tool to probe mechanisms of brain injury, but also will be used as a diagnostic and prognostic indicator of injury severity and outcomes.

Ongoing lines of research:

  1. Elucidating the mechanisms of chronic sleep disruption after mild concussion;
  2. Examining the role of social hormones (oxytocin, vasopressin) on mitigating the sequelae of brain injury, using the social prairie vole as a model organism;
  3. Understanding social influences on sleep using model organisms.
Techniques used include fluid percussion injury, chronic in vivo EEG/EMG recording, microdialysis, immunohistochemistry and behavior testing in mice and voles.

Personal Background


    Miranda Lim received a B.A. in Interdisciplinary Studies from University of Southern California in 1998. She obtained a combined M.D./Ph.D. from Emory University School of Medicine in 2006. She completed a residency in Neurology from Barnes-Jewish Hospital/Washington University School of Medicine in 2010. She went on to finish a clinical fellowship in Sleep Medicine in 2011 and a post-doctoral research fellowship from the University of Pennsylvania in 2013. In addition to running a basic research laboratory, she is Board Certified in Neurology and Sleep Medicine and staffs patients in the Portland VA Sleep Center.

Recent Announcements

  • The Lab is about to open! Renovations are underway...
    Posted Jul 16, 2013, 4:36 PM by Miranda Lim
  • Positions available We're looking for enthusiastic, able-bodied scientists to join our lab! Seeking various skill levels, including but not limited to:1. Previous experience in rodent surgery and behavior 2 ...
    Posted Jul 16, 2013, 4:51 PM by Miranda Lim
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