Online Resume

2016 – 2019     Mastectomy Skin Flap Imaging

noncontact imaging of 3D blood flow distribution in and around mastectomy skin flap right after mastectomy; for prediction of flap necrosis and early intervention (intra-operative measurement in OR).Technique: non-contact diffuse correlation spectroscopy/tomography; diffuse speckle contrast imaging. Instrumentation: CCD, optical lens, galvo-mirror, laser, fiber-optics, etc. My contribution: Engineering: New medical instrument development and validation; Clinical study: Protocol design; Data collection and analysis. Publication: S. Mazdeyasna, C. Huang, M. Zhao, N. B. Agochukwu, A. A. Bahrani, L. Wong, G. Yu, “Noncontact speckle contrast diffuse correlation tomography of blood flow distributions in tissues with arbitrary geometries”, Journal of Biomedical Optics, 23(9), 096005 (2018) link

C. Huang, D. Irwin, M. Zhao, Y. Shang, N. B. Agochukwu, L. Wong, G. Yu, “Noncontact 3-dimensional speckle contrast diffuse correlation tomography of tissue blood flow distribution”, IEEE Transactions on Medical Imaging, 36(10), 2017. link

N. B. Agochukwu*, C. Huang*, M. Zhao, A. Bahrani, L. Wong, G. Yu, “A novel noncontact diffuse correlation spectroscopy for assessing blood flow in mastectomy skin flaps: a prospective study in patients undergoing prosthesis-based reconstruction”, Plastic and Reconstructive Surgery, 140(1), 2017. link

2014 – 2019     Wound Imaging 

noncontact imaging of 3D blood flow distribution in and around wound tissue; for treatment validation and wound healing evaluation.   Technique: non-contact diffuse correlation tomography; diffuse speckle contrast imagingMy contribution: Engineering: Imaging system development and validation; Clinical study: subject recruitment (population: burn, diabetic ulcer, pressure ulcer, peripheral vascular disease); measurement coordination; protocol design; optical imaging data collection and analysis; ultrasound data collection and analysis (for comparison).Publication: 

M. Zhao, S. Mazdeyasna, C. Huang, N. B. Agochukwu, A. Bonaroti, L. Wong, G. Yu, "Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds", 2018 MHSRS Supplement to the Journal of Military Medicine. link 

2015 – 2018     Exercising Muscle Hemodynamics Monitoring

giving vitamin D supplement or placebo to older population, evaluate their muscle metabolisms by noninvasive optical measurements of tissue blood flow and hemodynamics in exercising muscles.  

Technique: near infrared spectroscopy; diffuse correlation spectroscopy. (laser, APD, fiber-optics)

My contribution:

Engineering: flowmetry and oximeter synchronization, adding external trigger (circuits + programming); instrument maintenance

Clinical study: protocol design and refinement;  optical data collection and analysis; MRI/MRS data collection and        analysis (Linux system, C shell script).

Publication:

D. T. Thomas; D. Schnell; M. Redzic; M. Zhao; H. Abraha; D. Jones; H. Brim; G. Yu. "Vitamin D repletion and aerobic training improves local in vivo measures of muscle lipid and oxygen consumption in aged, human subjects". Nutrients, 11(4), 930 (2019). link

B. Henry*, M. Zhao*, Y. Shang, T. Uhl, D. T. Thomas, E. S. Xenos, S. P. Saha, G. Yu, “Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise,” Journal of Biomedical Optics, 20(12), 125006 (2015). *Contributed equally. link

2012 spring: Micromouse Contest, Tianjin

function: Search puzzle and find shortest path from center to corner

My contribution: Schematic capture & PCB layout (whole system on one board, mixed-signal, PCB serves as vehicle chassis, strict space restriction, surface-mount components), PCB soldering (fine pitch SMD), circuit bring-up; hardware maintenance

(My first time integrating whole system on one PCB, with complicated mechanical requirements.)

2011 fall: TJU Robot Contest

function: Avoid obstacles. Deliver a ball to specified location

My contribution: Mechanical design; analog circuits design, debugging and hardware maintenance

(Our team won the 1st prize!)

2011 summer: China 5th MEMS Application Contest 

3D organ: Cubic electronic organ with keys on 4 faces. LED twinkling while playing. Preset music automatically playing when shaking the organ. Check video: Jingle Bells

My contribution: Mechanical design (autoCAD) and assembling; circuits and PCB design (load-bearing PCB serves as organ keyboard, another PCB for minimum mircocontroller system), debugging and hardware maintenance

(Our original design! We won 1st prize in final, ranked top 15 among nation-wide candidates.)

2010 fall: TJU Robot Contest 

function: Start the robot by given acoustic signal; Read bar codes; Keep balance on the seesaw; Look for metals. 

My contribution: Mechanical design; sensor circuits design, debugging and hardware maintenance

(It is my 1st robot. Our team got "Best Technical Prize"!)

SELECTED COURSE PROJECTS

05/2014: Time Coherence using LMS Adaption (MATLAB programming)

05/2013: Muscle Cell Classification using Support Vector Machine (MATLAB programming)

05/2013: Near-infrared Tissue Oximeter

Circuit: Dual wavelengths LED, optical signal detected by OPT101

LabView Programming: Control the time sequecne of the whole system, process and visualize data

I have also been the lab assistant for this course project since year 2014, facilitating students on reading schematic and circuits bring-up.

12/2012: Automatic Recognition of Musical Chords and Key  (MATLAB programming)

05/2011: ECG Detecting & Amplifying Circuit

system composition: pre-amplifier (main IC: AD620, module on handmade PCB), optical isolation (TLP521), low pass filter (4 order Butterworth filter), notch filter (twin-T 2 order notch filter, centered at power-line interference frequency), major amplifier (LM324). Power supply: 220V AC to ± 5V DC, isolated ± 5V DC power supply for preamplifier for safety concern.