Lim Laboratory

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding of the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

Contents
4. Hyuck Jin Lee, Young Geun Lee, Juhye Kang, Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang,* Sang-Rae Lee,* Mi Hee Lim,* Sang J. Chung* Chem. Sci. 2019, In Press. "Monitoring Metal–Amyloid-β Complexation by a FRET-Based Probe: Design, Detection, and Inhibitor Screening" 
3. Jong-Min Suh, Gunhee Kim, Juhye Kang, Mi Hee Lim* Inorg. Chem. 2019, 58, 8-17. "Strategies Employing Transition Metal Complexes to Modulate Amyloid-β Aggregation" 
2. Misun Lee, Mingeun Kim, Anjong Florence Tikum, Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim,* Jinheung Kim* Dyes Pigm. 2019, 162, 97-103. "A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates” 
1. Sugyeong Hong, You Kyung Go, Jeffrey S. Derrick, Sanghun Han, Jin Kim, Mi Hee Lim,* Sun Hee Kim* Inorg. Chem. 2018, 57, 12665-12670. "Advanced EPR Studies of a Ternary Complex of Copper, Amyloid-β and a Chemical Regulator” 
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Recent News

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March 2019: Congrats, Dr. Hyuck Jin Lee, for becoming as an Assistant Professor of Chemistry Education at Kongju National University. 
February 25, 2019: Welcome, our new graduate students, Mingeun and Juri, in our lab! 
February 2019: Congrats, Jiyeon Han, for the Best Oral Presentation Award from the 2019 KAIST School of Molecular Science BK21 Workshop! 
January 2019: Professor Lim becomes a Member of the Young Korean Academy of Science and Technology (Y-KAST). 
January 2019: Professor Lim becomes a Member of the Editorial Board in the Journal of Biological Inorganic Chemistry (JBIC). 
December 2018: Congrats, Professor Lim, for receiving the 2018 SBIC Early Career Award! (http://sbichem.org/SBIC-Awards.aspx) 
December 2018: Congrats, Hyuck Jin and Juhye, for publishing their work in Chem. Sci.! 
December 2018: Congrats, Misun and Mingeun, for their successful MS defense! 
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