Dr. György T. Balogh; Ph. D, Dr. Habil - Curriculum vitae

Associate Professor of Medicinal Chemistry

Address:

· Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics (BME),

H-1111 Budapest, Budafoki út 8, Hungary

· Department of Pharmacodynamics and Biopharmacy, University of Szeged

H-6720 Szeged, Eötvös u. 6, Hungary

Phone: (36-1)-463-2174

E-mail: gytbalogh@mail.bme.hu­; balogh.gyorgy@pharm.u-szeged.hu

Personal

Birth place, date: Budapest, Hungary; 21. 10. 1972.

Nationality: Hungarian

Home address: H-1172 Budapest, Aranykút u. 64, Hungary

Mobile phone: (+36-20)-4805172

Education, titles

2018: Habilitated Doctor, Dr. habil, at the Budapest University of Technology and Economics, Faculty of Chemical Technology and Biotechnology (Hab. thesis: In vitro non-cell-based permeability models in drug discovery)

2009: Master of Business Administration, MBA at the Budapest University of Technology and Economics, Faculty of Economic and Social Sciences (human management, financial and economic specializations)

2003: Ph.D. degree (PhD thesis: Biomimetic models for biological oxidation)

1999: Chemical engineer, M.Sc (Technical University of Budapest, Faculty of Chemical Technology and Biotechnology; Diploma thesis: Chemical and biological models for cytochrome P450 catalyzed metabolic processes)

1999: Bio-engineer, M.Sc (Technical University of Budapest, Faculty of Chemical Technology and Biotechnology; Diploma thesis: Chemical and biological models for cytochrome P450 catalyzed metabolic processes)

Professional experiences

2019-: Associate Professor of Organic and Medicinal Chemistry (BME, Department of Chemical and Environmental Process Engineering): Development of in vitro, tissue specific permeability assay and flow chemistry-based biomimetic catalyst systems for modelling drug metabolism.

2019-: Senior Research Fellow (University of Szeged (SzTE), Faculty of Pharmacy, Inst. of Pharmacodynamics and Biopharmacy): Development of in vitro, tissue specific permeability and physico-chemical characterization of API. Investigation of drug metabolism using different species derived liver microsomes.

2011-2018: Head of Laboratory at Gedeon Richter Plc, R&D Unit, Compound Profiling Laboratory: Development of novel in vitro, tissue specific permeability of lead compounds and in vitro biomimetic models for pharmacokinetic characterization of drug candidates in drug discovery process).

2005-2010: Head of Group at Gedeon Richter Plc, R&D Unit, Discovery Chemistry Research Laboratory: Introduction of comprehensive physico-chemical and analytical characterization of lead compound at early stage of drug discovery).

1999-2005: Research Scientist at Gedeon Richter Plc Pilot Plant II: Discovery of novel therapeutic possibilities of glucosaminoglycans (hyaluronan, chondroitin sulfate, heparan sulfate and it’s metal complexes); Development of MTS and HTS models for in vitro free radicals scavenger capacity.

1995-2000: PreMSc and Predoc Fellowship (Institute for Organic Chemistry, Budapest University of Technology and Economics, supervisor: Prof. Mihály Nógrádi and Prof. György M. Keserű): Total synthesis of macrocyclic bis(bibenzyls); Development of biomimetic (chemical) models for insecticide and human cytochrome P450 and nitric oxide synthase.

Research interests

Medicinal Chemistry: Physico-chemical (pKa, logP/D, aqueous solubility, permeability, chemical stability) characterization of lead compounds, drug candidates and natural products. Investigations of macromolecules – drug-like compounds interactions using spectrophotometric, UV-pH-metric and potentiometric methods (cyclodextrin – and serum albumin – drug systems). Application of in vitro models for drug metabolism (liver microsomal and metalloporphyrin-based biomimetic models and its using in flow chemistry system).

Analytical Chemistry: Purity and integrity characterization of drug-like compounds with wide range polarity and ionization property using versatile LC, LC-MS methods. Characterization of chemical fingerprint and identification of potential antioxidant compounds of plant extracts using LC-MS/(MS) techniques. Application of biomimetic chromatographic methods for investigation of drug – plasma protein binding. Identification of drug metabolism pathway and reactive metabolites using LC-MS/MS(HR-MS) techniques.

Teaching

Lectures

BME (in Hungarian): Optimization parameters of drug-like compounds (lecture) – Pharmacokinetics (lecture) – Lead optimization: From HTS hits to drug candidates (lecture) – Environmental chemistry (lecture)

BME (in English): Environmental chemistry and technology (lecture)

SzTE (in Hungarian and English): Biopharmacy (lecture)


Scientific achievements

4 book chapters (on Physico-chemical characterization of NCE and Physico-chemical and pharmacological properties of hyaluronan and its metal complexes) – 1 textbooks (co-author, in Hungarian: Phytochemistry: plant derived compounds in original drug discovery) – 64 Scientific articles (IF ~180) – all/independent citations ~ 531/709 – h-index (independent): 15 – 1 Patents (International: Zn-hyaluronan in multiple sclerosis therapy)

Awards

Márton Kajtár Award (2015); János Bolyai Research Grant (by Hungarian Academy of Science: 2010-2013); Lajos Kisfaludy Foundation Award (2005)


Selected publications

Book chapters:

1.Balogh, Gy.T. Physicochemical characterization of NCEs in early stage drug discovery

In: Tihanyi, K; Vastag, M (szerk.) Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates, Washington: Bentham Science Publishers Ltd., (2011) 33-51.

2. Illés, J.; Forrai, E.; Jávor, A.; Balogh, Gy.T.; Székely, Zs.; Furka, B. Chapter 10: Hyaluronan in Inflammation, Granulation and Regeneration: Biological and Farmacological Effects of Zinc Hyaluronan. In: Balázs, E.A.; Hascall, C. (szerk.) Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Vol. I Edgewater (NJ: Matrix Biology Institute, (2005) 803-808.

3. Illés, J.; Burger, K.; Forrai, E.; Balogh, Gy.T.; Székely, Zs. Chapter 1: Structure of Hyaluronan and its Properties in Solution.: Structure and Some Physico-Chemical Properties of Zinc Hyaluronan In: Balazs, EA; Hascall, C (szerk.) Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Vol. I Edgewater (NJ): Matrix Biology Institute, (2005) 21-28.

Guest editor at Drug Discovery Today (2018)

Balogh, Gy.T. Physicochemical characterisation in drug discovery. Drug Discov. Today: Technol. 27, 1-2. (2018)

Selected papers (2012-2019):

1. Dargó, G ; Vincze, A; Müller, J; Kiss, H.J.; Nagy, Z.Zs.; Balogh, Gy.T. Corneal-PAMPA: A novel, non-cell-based assay for prediction of corneal drug permeability. Eur. J. Pharm. Sci. 128, 232-239, (2019)

2. Dargó, G.; Boros, K.; Péter, L.; Malanga, M.; Sohajda, T.; Szente, L.; Balogh, Gy.T. Novel medium-throughput technique for investigating drug-cyclodextrin complexation by pH-metric titration using the partition coefficient method. Int. J. Pharm. 542, 100-107. (2018)

3. Fődi, T.; Ignácz, G.; Decsi, B.; Béni, Z.; Túrós, Gy.I.; Kupai, J.; Balogh-Weiser, D.; Greiner, I.; Huszthy, P.; Balogh, Gy.T. Biomimetic synthesis of drug metabolites in batch and continuous‐flow reactors. Chem. Eur J. 24(37), 9385-9392. (2018)

4. Müller, J.; Martins, A-; Csábi, J.; Fenyvesi, F.; Könczöl, Á.; Hunyadi, A.; Balogh, Gy.T. BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors. Eur. J. Pharm. Sci. 96, 571-577. (2017)

5. Galambos, J.; Bielik, A.; Krasavin, M.; Orgován, Z.; Domány, Gy; Nógrádi, K.; Wágner, G.; Balogh, Gy.T.; Béni, Z.; Kóti, J., Keserű, Gy.M. Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications J. Med. Chem. 60(6) 2470-2484. (2017)

6. Könczöl, Á.; Rendes, K.; Dékány, M.; Müller, J.; Riethmüller, E.; Balogh, Gy.T. Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba. J. Pharm. Biomed. Anal. 131, 167-174. (2016)

7. Németh, T.; Lévai, S.; Fődi, T.; Kupai, J.; Túrós, Gy.; Tóth, T.; Huszthy, P.; Balogh, Gy.T. A Novel Method for the Preparation of a Chiral Stationary Phase Containing an Enantiopure Acridino-18-Crown-6 Ether Selector J. Chrom. Sci. 53, 431-435. (2015)

8. Müller, J.; Esső, K.; Dargó, G.; Könczöl, Á.; Balogh, Gy.T. Tuning the predictive capacity of the PAMPA-BBB model Eur. J. Pharm. Sci. 79, 53-60. (2015)

9. Könczöl, Á.; Engel, R.; Szabó, K.; Hornok, K.; Tóth, S.; Béni, Z.; Prechl, A.; Máthé, I.; Balogh Gy.T. Topical analgesic, anti-inflammatory and antioxidant properties of Oxybaphus nyctagineus: Phytochemical characterization of active fractions J. Ethnopharm. 155(1), 776-784. (2014)

10. Könczöl, Á.; Müller, J.; Földes, E.; Béni, Z.; Végh, K.; Kéry, Á.; Balogh, Gy.T. Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery J. Nat. Prod. 76(4) 655-663. (2013)

11. Könczöl, Á.; Béni, Z.; Meszlényi-Sipos M.; Rill, A.; Háda, V.; Hohmann, J.; Máthé, I.; Szántay, Cs.; Keserű, Gy.M.; Balogh, Gy.T. Antioxidant activity-guided phytochemical investigation of Artemisia gmelinii Webb. ex Stechm.: Isolation and spectroscopic challenges of 3,5-O-dicaffeoyl (epi?) quinic acid and its ethyl ester. J. Pharm. Biomed. Anal. 59, 83-89. (2012)


Official list of publications

https://m2.mtmt.hu/gui2/?type=aut