Principal Investigator



Li-Jen Su PhD. (蘇立仁)
Assistant Professor
Office: Room. 616, 6F, College of Hakka Studies, NCU.
Lab.: Room. 208H, SyBBi, NCU.
TEL: +886-3-4227151 ext. 36111
FAX: +886-3-4273822

Education
2000-2006          Ph.D., Graduate Institute of Life Sciences, NDMC, Taiwan.
1998-2000           M.S., Graduate Institute of Basic Medical Science, CGU, Taiwan.
1989-1992            B.S., School of Pharmacy, Taipei Medical University, Taiwan.
 
Professional Career 
2013-present       Member, The Society of Chinese Natural Medicine.
2012-present       Director,  Core Facilities for High Throughput Experimental Analysis of SyBBi, NCU, Taiwan.   
2012-present       Member, Taiwan Genomic Medicine and Biomarker Society.
2011-present        Assistant Professor, Institute of Systems Biology and Bioinformatics, NCU, Taiwan.
1998-present       Member,  The Chinese Society of Cell and Molecular Biology.
2010-2011            Postdoctoral Scholar, National Science Council, Taiwan. 
2009-2010            Postdoctoral Fellow, Institute of Systems Biology and Bioinformatics, NCU, Taiwan.
2006-2008           Postdoctoral Fellow, Division of Thoracic Surgery, Department of Surgery, VGHTPE, Taiwan. 
 
Other Career 
2012-present        Director, World Leadership Education Foundation (財團法人世界領袖教育基金會  董事)
2009-present       Consultant, Taiwan Woman and Child Health Promoting Association (社團法人婦幼健康促進協會  專業諮詢委員召集人)
2008-2012            Computation Manager, 3L Parienting and Family Supporting Center
2006-2013            Associate Director, Truth-Virtue-Beauty Chinese Medical Clinic 
1995-1998             Director, I-Sin-Tang Chinese Pharmacy Store 

    Link: http://scholar.google.com/citations?hl=en&user=LaLo_9oAAAAJ



Journal Publications

          
          2013-present

Shiu LY, Lai CH, Yang CH, Tseng AH, Lee HC and Su LJ.
Identification of Genomic Alterations in Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma.
International Journal of  Head and Neck Science  2017; 1 (1): 47-84http://www.sciencedirect.com/science/article/pii/S0898656814003180#


Tseng AH, Yang JC, Chen CH, Chen CH, Hsu SLLee MH, Lee HC* and Su LJ*.
An in vivo Molecular Response Analysis of Colorectal Cancer Treated with  Astragalus membranaceus Extract.
Oncology Reports.  2016; 35 (2): 659-668. http://www.sciencedirect.com/science/article/pii/S0898656814003180#
*These authors contributed equally.


Liu CC, Su LJ, Tsai WY, Sun HL, Lee HC and Wong CS.
Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: association with upregulated expression of the circardian gene NPAS2.
Life Sciences. 2015; 141: 20-24. http://www.sciencedirect.com/science/article/pii/S0898656814003180#

Chen CH, Chang AY, Li SH, Tsai HT, Shiu LY, Su LJ, Wang WL, Chiu TJ, Luo SD, Huang TL and Chien CY.
Suppression of Aurora-A-FLJ10540 Signaling Axis Prohibits the Malignant State of Head and Neck Cancer.
Molecular Cancer. 2015; 14(1): 83. [SCI: 5.397; Rank: 29/203 in ONCOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#

Huang HL, Wu CY, Su LJ, Huang YJ, Charoenkwan P, Chen WL, Lee HC, Chu CCW and Ho SY.
Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival data.
BMC Bioinformatics. 2015; 16: 54 [SCI: 2.672; Rank: 8/52 in MATHEMATICAL & COMPUTATIONAL BIOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#

Chen CH, Hsu CL, Huang SH, Chen SY, Hung YL, Chen HR, Wu YC, Su LJ* and Lee HC*.
Method Designed to Respect Molecular Heterogeneity Can Profoundly Correct Present Data Interpretations for Genome-Wide Expression Analysis.
PLoS ONE. 2015; 10(3): e0121154. [SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES ; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#
*These authors contributed equally.

Wei TY*, Hsia JY*, Chiu SC*, Su LJ*, Juan CC*, Lee YC*, Chen JM*, Chou HY, Huang JY, Huang HM and Yu CT. 
Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
Cellular Signalling. 2014; 26(12): 2940-2950.  [SCI: 4.471; Rank: 63/185 in CELL BIOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#
*These authors contributed equally.
Cheng TM, Liu YR, Wu MH, Chang CC, Shieh DB,  Su LJ, and Yen Y. 
Carcinoembryonic cell adhesion molecule 6 as a therapeutic target for breast cancer. 
The FASEB Journal. 2014; 28 (1 Supplement): 1048.2 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Chiang KC, Yeh CN, Lin KJ, Su LJ, Yen TC, Pang JHS, Kittaka A, Sun CC, Chen MF,Jan YY, Chen TC, Juang HH and  Yeh TS
Chemopreventive and Chemotherapeutic Effect of Dietary Supplementation of Vitamin D on Cholangiocarcinoma in a Chemical-Induced Animal Model.
Oncotarget. 2014; 5 (11): 3849-61. [SCI: 6.636; Rank: 21/197 in ONCOLOGY; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Chien CY, Tsai HT, Su LJ, Chuang HC, Shiu LY, Huang CC, Fang FM, Yu CC, Su HT, and Chen CH. 
Aurora-A signaling is activated in advanced stage of squamous cell carcinoma of head and neck cancer and requires osteopontin to stimulate invasive behavior. 
Oncotarget. 2014; 5(8): 2243-2262. [SCI: 6.636; Rank: 21/197 in ONCOLOGY; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Hwang CF, Shiu LY, Su LJ, Yin YF, Wang WS, Huang SC, Chiu TJ, Haung CC, Zhen YY, Tsai HT, Fang FM, Huang TL and Chen CH.

Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis.

PLoS ONE. 2013; 8(12): e84218[SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218


Su LJ, Chang CC, Yang CH, Hsieh SJ, Wu YC, Lai JM, Tseng TL, Huang CYF and Hsu SL. 

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro.

PLoS ONE. 2013; 8(1): e53988.  [SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES; Time cited: 0] 


Chen CH, Chuang, HC, Huang CC, Fang FM, Huang HY, Tasi HT, Su LJ, Shiu LY, Leu S, and Chien CY. 

Overexpression of Rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A modulation. 

American Journal of Pathology. 2013; 182(2): 516-528. [SCI: 4.890; Rank: 6/79 in PATHOLOGY; Time cited: 0


 2008-2012


Chiang KC, Yeh CN, Chen SC, Shen SC, Hsu JT, Yeh TS, Pang JHS, Su LJ, Takano M, Kittaka A, Juang HH and Chen TC.

MART-10, a new generation of vitamin D analog, is more potent than 1a,25-dihydroxyvitamin D3 in inhibiting cell proliferation and inducing apoptosis in ER+ MCF-7 breast cancer cells.

Evidence-Based Complementary and Alternative Medicine. 2012; 2012: 310872[SCI: 4.774; Rank: 1/22 in INTEGRATIVE & COMPLEMENTARY MEDICINE; Time cited: 0] 


Kuo YL, Chang PMH, Liu YM, Chen PH, Lee PY, Liu RS, Lai JM, Tien YJ, Wu YC, Su LJ, Kao CY, Chen CH and Huang CYF. 

In silico therapeutic drug screening for reversing the lung adenocarcinoma overexpressed gene signatures. 

Journal of Cancer Science & Therapy. 2012; 1: 101. [SCI: 5.620; Rank: --; Time cited: 0]  doi: 10.4172/scientificreports.101.


Wei TYW*, Juan CC*, Hsia JY*, Su LJ*, Lee YCG*, Chou HY, Chen JMM, Wu YC, Chiu SC, Hsu CP, Liu KL and Yu CTR. 

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

Cancer Science. 2012; 103(9): 1640-50. [SCI: 3.325; Rank: 67/194 in ONCOLOGY; Time cited: 1] 

*These authors contributed equally. 


Chen CH, Shiu LY, Su LJ, Huang CYF, Huang SC, Huang CC, Yin YF, Wang WS, Tsai HT, Fang FM, Chuang WC, Kang HC and Hwang CF.

FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes tonasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway

Journal of Translational Medicine. 2012; 10: 93. [SCI: 3.474; Rank: 31/111 in MEDICINE, RESEARCH & EXPERIMENTAL; Time cited: 0] 


Su LJ, Yang CH, Huang SF, Yuo YL, Hsieh HC, Tseng TL, Chen CH, Hsu SL and Huang CY. 

Evaluation of the Chinese medicinal herb, Graptopetalum paraguayense, as a therapeutic treatment for liver damage in rat models. 

Evidence-Based Complementary and Alternative Medicine. 2012; 2012: 256561. [SCI: 2.175; Rank: 1/22 in INTEGRATIVE & COMPLEMENTARY MEDICINE; Time cited: 0]  doi: 10.1155/2012/256561.


Su LJ*, Wu LC and Tseng ALH. 

Comparison of mRNA Gene Expression Analysis between Quantitative-real time PCR Assay and DNA Microarray Based Assay. 

Adv Biomed Eng. 2011; 3-5: 158-67 [EI; Time cited: 0] (ISSN: 2160-0589, ISSN/ISO: Advances in Biomedical Engineering

*First and corresponding author. 

 

Yu CT, Hsia JY, Hseih YC, Su LJ, Lee TC, Ku CF, Chen KS, Maureen Chen JM, Wade Wei TY, Lee YC, Huang CY, Wu YC, Yang CY and Hsu SL. 

The Novel Protein Suppressed in Lung Cancer Down-Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A. 

Journal of Thoracic Oncology. 2011; 6(6): 988-997.  [SCI: 3.661; Rank: 9/48 in RESPIRATORY SYSTEM; Time cited: 0

 

Hwang CF, Chien CY, Huang SC, Yin YF, Huang CC, Fang FM, Tsai HT, Su LJ, and Chen CH. 

Fibulin-3 is associated with tumor progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity. 

The Journal of Pathology. 2010; 222(4):367-79. [SCI: 6.318;  Rank: 3/78 in PATHOLOGY; Time cited: 7 [PDF]

 
Wu YC*, Su LJ*, Wang HW, Lin CFJ, Hsu WH, Chou, TY, Perng, DW, Wang, LS, and Hsueh CT. 
Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. 
Journal of Thoracic Oncology. 2010; 5(8): 1167-1174. [SCI: 3.661; Rank: 9/48 in RESPIRATORY SYSTEM; Time cited: 4 [PDF]
*These authors contributed equally. 
 
Chen CH, Lai JM, Chou TY, Chen CY, Cheng TS, Su LJ, Whang-Peng J, Chou CK, Wu YC, and Huang CYF. 
VEGF-A upregulates FLJ10540 expression and modulates migration and invasion of lung cancer cells via PI3K/AKT pathway. 
PLoS ONE. 2009; 4(4): e5052. [SCI: 4.092; Rank: 12/84 in BIOLOGY; Time cited: 16]  [PDF]
 
Wong FH*, Huang CYF*, Su LJ*, Wu YC, Lin YS, Hsia JY, Tsai HT, Lee SA, Lin CH, Chen PM, Chen YJ, Liang SC, Lai JM, and Yen CC. 
Microarray profiling delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. 
International Journal of Oncology. 2009; 34(1): 117-28. [SCI: 2.399; Rank: 108/194 in ONCOLOGY; Time cited: 13 [PDF]
*These authors contributed equally. 

2003-2007
 
Su LJ, Chang CW, Lin CJ, Wu YC, Chen CH, Liang SC, Lin CH, Chen KC, Whang-Peng J, and Huang CYF. 
Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme. 
BMC Genomics. 2007; 8: 140. [SCI: 4.073; Rank: 26/157 in  BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 62]  [PDF]
 
Hsu CN, Lai JM, Liu CH, Tseng HH, Lin CY, Lin KT, Yeh HH, Sung TY, Hsu WL, Su LJ, Lee SA, Chen CH, Lee GC, Lee DT, Shiue YL, Yeh CW, Chang CH, Kao CY, and Huang CY. 
Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online). 
BMC Bioinformatics. 2007; 8: 66. [SCI: 2.751; Rank: 6/47 in MATHEMATICAL & COMPUTATIONAL BIOLOGY; Time cited: 19] [PDF]
 
Su LJ, Hsu SL, Yang JS, Tseng HH, Huang SF, and Huang CY. 
Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis. 
Gene Expression. 2006;13(2): 107-32. [SCI: 1.308; Rank: 111/157 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 8] [PDF]
 
Su LJ*, Lin YS*, Yu CT*, Wong FH*, Yeh HH, Chen SL, Wu JC, Lin WJ, Shiue YL, Liu HS, Hsu SL, Lai JM, and Huang CY. 
Gene expression profiles of the aurora family kinases. 
Gene Expression. 2006; 13(1): 15-26. [SCI: 1.308; Rank: 111/157 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 25] [PDF]
*These authors contributed equally. 
 
Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, and Huang CY. 
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. 
Molecular & Cellular Proteomics. 2004; 3(1): 93-104. [ SCI: 7.398; Rank: 5/72 in BIOCHEMICAL RESEARCH METHODS; Time cited: 23] [PDF]
 
Chao CC, Su LJ, Sun NK, Ju YT, Lih JC, and Lin-Chao S. 
Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. 
Journal of Neuroscience Research. 2003; 74(2): 248-54. [ SCI: 2.738; Rank: 123/243 in  NEUROSCIENCES; Time cited: 12] [PDF]
2011 JCR Science Edition 

Short Communications

Tseng ALH, Chung FH, Lee HC, Wu LC, Chen CH, and Su LJ. 
Microarray analysis and establishment of drug screening platform using 5-fluorouracil resistance HCT116 colon cancer cells
Genomic Medicine, Biomarkers, and Health Sciences. 2012; 4 (1): 21-27 doi:10.1016/j.gmbhs.2012.04.001

 

Conference Presentations 

Oral presentation

2011.07.30
Comparison of mRNA Gene Expression Analysis between Quantitative-real time PCR Assay and DNA Microarray Based Assay. 
(2011 International Conference on Agricultural and Natural Resources Engineering; ANRE 2011)

Posters

2013-present

Chen CH, Su LJ
Aurora-A/FLJ10540/MMP Signaling Suppression Prevents the Malignant State of Head and Neck Cancer.
The Joint Meeting of 4th Congress of ASHNO 39th Annual Meeting of JSHNC. 2015; P131. 
Tseng ALH and Su LJ
BP002,  a Traditional Chinese Medicine, Inhibits Human Colorectal Cancer Cell Growth in Animal Model.
The 12th Annual Meeting of Japanese Society of Medical Oncology (JSMO2014). 2014; P1-11-5.

Cheng TM, Liu YR, Wu MH, Chang CC, Shieh DB,  Su LJ, and Yen Y. 
Carcinoembryonic cell adhesion molecule 6 as a therapeutic target for breast cancer. 
2014 International Clinical Molecular Diagnostics Symposium. Taipei, Taiwan. 2014: P14. 
(This post had been awarded the First Prize of post competition.)

Cheng, TM, Liu YR, Chang CC, Chu HL, Shieh DB, Su LJ, and Yen Y.
Carcinoembryonic cell adhesion molecule (CEACAM) 6 as a therapeutic target for breast cancer. 
Experimental Biology. ASIP. San Diego, USA (ASIP). 2014; 14-2758-EB.
(This abstract has been selected for a special Breast Cancer Poster Discussion Session sponsored by the ASIP Scientific Interest Groups)

Tseng ALH, Lee HC, Chen CH, and Su LJ
Microarray analysis of resistant HCT116 colon cancer cell lines and the effect of traditional Chinese medicine BP002. 
The 28th Joint Annual Conference of Biomedical Sciences. 2013; P626.

Su LJ, Huang SH, Chen SY, Hsu CL, Hung YL, Lee HC and Chen CH. 

WABE, a novel method for identifying differentially expressed genes based on sample-specific errors and z-test provides superior reliability compared to standard methods based on gene-specific errors and t-test.

The 28th Joint Annual Conference of Biomedical Sciences. 2013; P897.


Su LJ, Chang CC, Yang CH, Hsieh SJ, Wu YC, Lai JM, Tseng TL, Lin JJ, Huang CYF and Hsu SL. 

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro.

The 28th Joint Annual Conference of Biomedical Sciences. 2013; P896.


Wu CJ, Su LJ, Tsai HT and Chen CH. 
Fibulin-5 promotes nasopharyngeal carcinoma cell motility via the FLJ10540/AKT pathway and correlates with poor prognosis.
The 21th Symposium on Recent Advances in Cellular and Molecular BiologyCSCMB. 2013; 32.

Tsai HT, Su LJ, Wu CJ and Chen CH. 
Overexpression of Rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A modulation.
The 21th Symposium on Recent Advances in Cellular and Molecular BiologyCSCMB. 2013; 229.

Su LJ, Huang SH, Chen SY, Hsu CL, Hung YL, Lee HC and Chen CH. 
Novel method for identifying differentially expressed genes based on sample-specific errors and z-test provides superior reliability compared to standard methods based on gene-specific errors and t-test.
The 21th Symposium on Recent Advances in Cellular and Molecular BiologyCSCMB. 2013; 267.

2008-2012

Su LJ, Yu CTR, Chen CH, Chou TY, Wu CW and Wu YC. 
Gene expression integration to delineate the molecular basis of clinical diagnosis markers in non-small-cell lung cancer by systems biology approach. 
2012 International Symposium on Clinical and Translational Cancer Research (2012年國際癌症轉譯暨臨床醫學學術研討會). 2012; 15.

Tseng ALH, Chung FH, Lee HC, Wu LC, Chen CH, and Su LJ
Microarray processing workflow and establishment of drug screening platform using HCT116 colon cancer cell line. 
101年台灣基因醫學暨生物標記學會年會暨基因標記暨轉譯醫學應用研討會2012; P06.

Chen CH, Wu CJ, Tsai HT and Su LJ. 
FLJ10540 and Osteopontin Synergistically Contributes to the Proliferation, Migration and Invasion in Nasopharyngeal Cancer Cell Lines via CD44 Pathway. 
The 27th Joint Annual Conference of Biomedical Sciences. 2012; A51.

Chen CH, Wu CJ, Tsai HT and Su LJ
Modulated FLJ10540 by Osteopontin Is Associated with Tumor Progression in Nasopharyngeal Carcinomas and Contributes to Osteopontin-elicited Proliferation, Migration and Invasion in Nasopharyngeal Cell Lines via CD44 Pathway. 
The 20th Symposium on Recent Advances in Cellular and Molecular Biology, CSCMB. 2012; --.

Tsai HT, Chen CH,  Chien CY and Su LJ. Overexpression of Rap-1 is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion. 
The 20th Symposium on Recent Advances in Cellular and Molecular Biology, CSCMB. 2012; --.

Chen CH, Su LJ and Wu CJ. 
Modulated aberrant expression of FLJ10540 by chemokine ligand 2 (CCL2) is associated with poor prognosis in oral cavity squamous cell carcinoma. 
Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS). 2011; --.

Chen CH, Su LJ, Tsai HT, and Chien CY. 
TSG101 downregulates FLJ10540 and modulates migration and invasion of OCSCC via AKT pathway. 
The 2011 Annual Meeting and International Conference of Taiwan Head and Neck Society. 2011;--.
 
Wu LC, Wu YC, Huang CYF, Tsou TS, Chen GC and Su LJ
Redefinition of Affymetrix probe setd for gene expression measurements. 
The Seventh Cross-Strait Workshop on Biology Inspired Theoretical Science (BITS 7). 2010; A3. 
 
Hsu SL, Huang CYF, Yang JC, Huang SF and Su LJ
Liver injury therapeutic evaluation of GP in rat model. 
The Seventh Cross-Strait Workshop on Biology Inspired Theoretical Science (BITS 7). 2010; A4.
 
Wu YC, Chen CH, Su LJ, Whang-Peng J, and Huang CYF. 
Integrated microarray datasets reveal the VEGF-A/FLJ10540/PI3K/AKT pathway in lung adenocarcinoma. 
AACR Meeting Abstracts. 2009; 3923.
 
Wu YC, Chen CH, Lai MJ, Chou TY, Su LJ, Whang-Peng J, Chou CK, and Huang CYF. 
VEGF-A upregulates FLJ10540 expression and modulates migration and invasion of lung cancer cells via PI3K/AKT pathway. 
AACR Meeting Abstracts. 2008; LB-61.

2003-2007
 
Wu YC, Chen CH, Huang CYF, Su LJ, and Whang-Peng J. 
Identification of Therapeutic Targets for Lung Adenocarcinoma by Functional Genomics. 
AACR Meeting Abstracts. 2007; LB-52.
 
Wu YC, Chen CH, Huang CYF, Su LJ, and Whang-Peng J. 
Identification of Therapeutic Targets for Lung Adenocarcinoma by Functional Genomics. 
Asia-Pacific Journal of Clinical Oncology. 2006; 2( s1): A32. 
 
Su LJ, Hsu SL, Yang JS, Huang SF, Tsou AP, Tseng HH, and Huang CYF.
Global gene expression profiling of dimethylnitrosamine induced liver fibrosis in rat model, from pathological and biochemical data to microarray analysis.
AACR Meeting Abstracts. 2005; 4.


Presentations


2016.10.17
In vitro analysis of molecular mechanisms underlying effects of Chinese medicine BP011w to inhibit migration of lung adenocarcinoma. (慈濟醫院台北分院 中醫部)

2015.05.14
The high throughput platform applications in lung and colorectal cancer studies. (三軍總醫院 病理部)
2012.06.07
Microarray application in Chinese medicine development. (Department of Medical Informatics, Tzu Chi University; 慈濟大學 醫學資訊學系)

2010.01.21
Microarray application in Chinese medicine development and disease-related marker prediction. (Shanghai Institute of Applied Physics, Chinese Academy of Sciences; 中国科学院 上海应用物理研究所 )
 
2010.01.19
Microarray application in Chinese medicine development and disease-related marker prediction. (Institute of Systems Biology, Shanghai University; 上海大学 系统生物技术研究所)
 
2008.08
教育部顧問室"生物及醫學科技人才培育先導型計畫"-生技中草製藥之暑期課程 中草藥之生物資訊學 (台北醫學大學 生藥研究所)。
 
2008.08
97尖端生物-中草藥對基因表現活性之篩檢-中草藥之基因表現分析試驗 (台北醫學大學 生藥研究所)。
 
2007.09
教育部顧問室"生物及醫學科技人才培育先導型計畫"-生技中草製藥之暑期課程 中草藥之生物資訊學 (台北醫學大學 生藥研究所)。
 
2007.08
96尖端生物-中草藥對基因表現活性之篩檢-中草藥之基因表現分析試驗 (台北醫學大學 生藥研究所)。
 
2006.7.16
Application of microarray in basic research and medical practice. (台灣神經腫瘤學學會)。
 
2005.08-2005.12
通識學科教學-近代生物醫學相關發展 (萬能科技大學 環境工程學系)。
  

Patents

陳志浩 (Chih-Hao Chen)、李弘謙 (H.C. Lee)、蘇立仁 (Li-Jen Su)
"實施於計算機的差異表現基因辨認方法以及此方法之電腦可讀取記錄媒體" (Computer-implemented method for identifying deferentially expressed genes and computer readable storage medium for storing the method)。
台灣發明第 I 472944 號專利權, 2015.02.11, (2015/02-2032/12)。

https://sites.google.com/site/mdxtlab/princirpal-investigator/%E6%8E%83%E6%8F%8F.jpg?attredirects=0


謝惠珠 (Hui-Chu Hsieh)、曾錙翎 (Tzu-Ling Tseng)、蘇立仁 (Li-Jen Su)、黃奇英 (Chi-Ying Huang)、徐士蘭 (Shih-Lan Hsu) 
“肝纖維化及/或肝硬化之生物標誌及其檢驗方法” (Biomarkers for liver fibrotic injury) 。
美國發明第7,972,785 號專利權, 2011.07.05, (2011/07-2023/12)。 
新加坡發明第 134283 號專利權, 2009.11.30, (2009/11-2027/01)。
日本發明第 4297942 號專利權, 2009.04.24, (平成21年04月24日), (2009/04-2027/01) 。

      

 

Positions and Honors

104學年度國立中央大學「院教學優良獎」, in 2016.
103學年度國立中央大學「校務服務傑出獎」, in 2015.

103學年度國立中央大學「研究傑出獎」Outstanding research award, National Central University, in 2015.  

The First Prize of post competition for “International Clinical Molecular Diagnostics Symposium, Taipei, Taiwan” in 2014.

A selected abstract for “Special Breast Cancer Poster Discussion Session” Experimental Biology. ASIP. San Diego, USA in 2014.

Award for U. S. Patent (US 7,972,785), ITRI in 2011.

Award for Singapore Patent (P-No. 134283), ITRI in 2010.

Award for Japan Patent (特許第4297942 號), ITRI in 2009.

PhD Student Thesis Award, Graduate Institutes of Life Science, NDMC in 2006.
 
2nd Award, ITRI Biotechnological forum in 2005.
 
Poster Award, 19th Symposium on Biology and Medicine in 2004.
 
Award, Liver Disease Prevention and Treatment Research Foundation in 2003.
 
Poster Award, 6th Symposium on Recent Advances in Cellular and Molecular Biology in 2000.


Manuscripts

Evaluating the effect of Graptopetalum paraguayense, an antifibrotic herb, on dimethylnitrosamine-induced liver fibrosis in rats by differential proteomics. (Submitted)

Expression of Aurora-A promotes cell migration and invasion through increased MMP-2 activity in nasopharyngeal carcinoma cells. (Submitted)

Downregulation of lipocalin 2 (Lcn2) oncogene expression by vitamin D supplementation plays a vital role in preventing cholangiocarcinoma in rats. (Submitted)

Microarray-Generated Prediction Model for Recurrence of Non-small Cell Lung Carcinoma. (Submitted)



Patents under review

Computer-implemented method for identifying deferentially expressed genes and computer readable storage medium for storing the method. (US)