Publications


Many papers (and supplementary info if available) downloadable as PDF files

* Equal Contribution     (Lab members)

2010.

26.   Bandyopadhyay S, Mehta M, Kuo D, Sung M-K, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guenole A, van Atikum H, Shokat KM, Kolodner RD, Huh W-K, Aebersold R, Keogh M-C**, Krogan NJ** & Ideker T

**

 (2010) Rewiring of genetic networks in response to DNA damage. Science 330:1385-9 <PDF> <SOM> <Accompanying Perspectives article>  
** Corresponding authors

25.   Mehta M, Braberg H, Wang S, Lozsa A, Shales M, Solache A, Krogan NJ Keogh M-C (2010) Individual lysine acetylations on the N-terminus of S.cerevisiae H2A.Z are highly but not differentially regulated. J Biol Chem  285:39855-65 <PDF>

24.   Mehta M*, Kim H-S* Keogh M-C (2010) Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant? J Biol 9:3 (Review) <PDF>

2009.

23.    Kim H-S*, Vanoosthuyse V*Fillingham J, Roguev A, Watt S, Kislinger T, Treyer A, Carpenter LR, Bennett CS, Emili A, Greenblatt JF, Hardwick KG, Krogan NJ, Bähler JKeogh M-C (2009) An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Nat Struct Mol Biol 16:1286-93. <PDF> <Supplementary>

22.    Fiedler D, Braberg H*Mehta M*, Chechik G*, Cagney G*Mukherjee PSilva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FCP, Weissman JS, Keogh M-C, Koller D, Shokat KM & Krogan NJ. (2009) Functional organisation of the S.cerevisiae phosphorylation network. Cell  136:952-63. <PDF>

21.    Ahn SH, Keogh M-C & Buratowski S.  (2009) Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II. EMBO J  28:205-12. <PDF>

2008.

20.    Fillingham JF, Recht J, Silva AC, Suter B, Emili A, Stagljar I, Krogan NJ, Allis CD, Keogh M-C & Greenblatt JF.  Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol 28: 4342-53. <PDF>

2006.

19.    Fillingham J, Keogh M-C & Krogan NJ (2006) gammaH2AX and its role in DNA double-strand break repair. Biochem Cell Biol  84:559-68. <PDF>

18.    Keogh M-C, Mennella TA, Sawa C, Berthelet S, Krogan NJ, Wolek A, Podolny V, Carpenter LR, Greenblatt JF, Baetz K  & Buratowski S (2006) The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev 20:660-5. <PDF> <Supplement>

17.    Keogh M-C*, Kim J-A*, Downey M*, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF & Krogan NJ (2006) A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439:497-501 (2005 doi:10.1038/nature04384)<PDF> <Supplementary> <Nature N&V> <Cell Molecular Biology Select>

2005.

16.    Chowdhury D, Keogh M-C, Ishii H, Peterson CL, Buratowski S & Lieberman J (2005) gammaH2AX dephosporylation by Protein Phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 20:801-9. <PDF> <Supplementary> <Nature N&V> <Cell Molecular Biology Select>

15.    Keogh M-C, Kurdistani S, Morris SA, Ahn SH, Podolny V, Collins SR, Shuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S & Krogan NJ (2005) Co-transcriptional Set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell  123:593-605.<PDF> <Supplementary> <Cell MiniReview> <Harvard Focus>

14.    Starita LM*, Horwitz AA*, Keogh M-C, Ishioka C, Parvin JD & Chiba N (2005) BRCA1 / BARD1 ubiquitinate phosphorylated RNA Polymerase II. J Biol Chem  280:24498-505. <PDF>

2004.

13.    Krogan NJ*, Lam MHY*, Fillingham J*, Keogh M-C*, Gebbia M, Li J, Datta N, Wu X, Cagney G, Buratowski S, Emili A & Greenblatt JF (2004) Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell  16:1027-34. <PDF>

12.    Krogan NJ*, Baetz K*, Keogh M-C*, Datta N, Sawa C, Kwok TCY, Thompson NJ, Davey MG, Pootoolal J, Hughes TR, Emili A, Buratowski S, Hieter P & Greenblatt JF (2004) Regulation of chromosome stability by the Histone H2A variant Htz1, the Swr1 chromatin remodeling complex and the Histone AcetylTransferase NuA4. Proc Natl Acad Sci USA 101:15313-8. <PDF>

11.    Keogh M-C & Buratowski S (2004) Using chromatin immunoprecipitation to map co-transcriptional mRNA processing in Saccharomyces cerevisiae. Methods Mol Biol  257:1-16.

2003.

10.    Krogan NJ*, Keogh M-C*, Datta N, Sawa C, Ryan OW, Ding H, Haw RA, Pootoolal J, Tong A, Canadien V, Richards DP, Wu X, Emili A, Hughes TR, Buratowski S & Greenblatt JF (2003) A Snf2-family ATPase complex required for recruitment of the Histone H2A variant Htz1. Mol Cell  12:1565-76. <PDF> <Science Perspectives> <Cell Minireview>

9.    Keogh M-C, Podolny V & Buratowski S (2003) Bur1 kinase is required for efficient transcription elongation by RNA Polymerase II. Mol Cell Biol  23:7005-18. <PDF>

2002.

8.    Takagi T, Cho E-J, Janoo RTK, Podolny V, Takase Y, Keogh M-C, Woo S-A, Fresno-Cohen LD, Hoffman CS & Buratowski S (2002) Divergent subunit interactions among fungal mRNA 5'-capping machineries. Euk Cell 3:448-57. <PDF>

7.    Keogh M-C, Cho E-J, Podolny V & Buratowski S (2002) Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Mol Cell Biol  22:1288-97. <PDF>

</= 2000.

6.    Rodriguez CR, Cho E-J, Keogh M-C, Moore CL, Greenleaf AL & Buratowski S (2000) Kin28, the TFIIH-associated CTD kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. Mol Cell Biol  20:104-12. <PDF>

5.    Keogh M-C & Chen D (1999) Efficient liposome-mediated gene transfer to rabbit carotid arteries in vivo. In Methods in Molecular Medicine - Vascular Disease: Molecular Biology and Gene Therapy Protocols. Humana Press. Ed. AH Baker. 

4.    Schmitt JF*, Keogh M-C*, Chen D, Taylor T, Weston K, Lupu F, Kakkar VV & Lemoine NR (1999) Tissue-selective dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation. Gene Therapy  6:1184-91. <PDF>

3.    Keogh M-C, Chen D, Schmitt JF, Dennehy U, Kakkar VV & Lemoine NR (1999) Design of a muscle-cell specific expression vector utilizing human vascular smooth muscle alpha-actin regulatory elements. Gene Therapy  6:616-28. <PDF>

2.    Keogh M-C*, Chen D*, Shaper N, Lupu F, Schmitt JF, Kakkar VV & Lemoine NR (1997) High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex. Gene Therapy  4:162-71. <PDF>

1.    Keogh M-C, Elliot J, Norton T & Lake RA (1997) A function for CD2 on murine B cells? Immunol Cell Biol  75:333-9. 

Journals 

(2008 Impact Factor)

Cell (31.3)

BCB (2.5)

EMBO J (8.3)

Euk Cell (3.8)

Genes Dev (13.6)

Genetics (4.0)

JBC (5.5)

Mol Cell (12.9)

Mol Cell Biol (5.9)

Mol Biol Cell (5.6)

Nature (31.4)

NSMB (11)

PLOS Biol (12.7)

PLOS Genet (8.9)

PNAS (9.4)

Science (28.1)