Chromatin resources 


Updated 10/30/08

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LINKS 

Chromatin structure / function: with links to epigenetics protocols
 
histone.com: includes updated modification maps (Upstate)

Kadonaga - Chromatin structure: Chromatin / Transcription lecture
 
 Waterborg Chromatin: Key concepts plus info on acetylation
 
Chromatin Antibodies: Upstate and Abcam 
 
chromDB: the plant chromatin database
 
cellnucleus.com: videos of chromatin dynamics
 
 Epigenome: European epigenetics research 

 

Chromatin Meetings '08

Chromatin Structure & Function - GRC; May 11-16; Italy

 

Chromatin Meetings '09

Epigenetics & Human disease - Keystone series; Jan 5-10; Breckenridge, CO

Histones, nucleosomes, chromosomes and genomes Abcam meeting; Feb 9-11; Singapore

Chromatin Dynamics & Higher Order Organization - Keystone series; Feb 25-Mar 2; Idaho

Chromatin, Replication & Chromosomal Stability Abcam meeting; Jun 15-16; Copenhagen, Denmark



Chromatin Basics


The Nucleosome Core Particle

 

From: Richmond lab, Zurich 

The basic repeating unit of chromatin is the nucleosome core particle (NCP): 146bp of DNA wrapped around a core histone octamer of two H2A-H2B dimers and a (H3-H4)2 tetramer (Luger, 2003).

 

Introducing variation to NCPs

Variation can be introduced by covalently modifying the histones (usually but not exclusively on their protruding N-terminal tails) by a variety of enzymatic activities (including acetylation, methylation, phosphorylation and ubiquitination) (Cosgrove and Wolberger, 2005; Jenuwein and Allis, 2001; Strahl and Allis, 2000). Variant histones can also be deposited at specific sites to replace the major histones assembled during DNA replication (Malik and Henikoff, 2003). Finally, nucleosomes can be remodeled by a superfamily of ATPases (Johnson et al, 2005).

 

A Histone Code 

(In Progress - 10/24/06)