Chromatin resources 

Updated 10/30/08

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Chromatin structure / function: with links to epigenetics protocols includes updated modification maps (Upstate)

Kadonaga - Chromatin structure: Chromatin / Transcription lecture
 Waterborg Chromatin: Key concepts plus info on acetylation
Chromatin Antibodies: Upstate and Abcam 
chromDB: the plant chromatin database videos of chromatin dynamics
 Epigenome: European epigenetics research 


Chromatin Meetings '08

Chromatin Structure & Function - GRC; May 11-16; Italy


Chromatin Meetings '09

Epigenetics & Human disease - Keystone series; Jan 5-10; Breckenridge, CO

Histones, nucleosomes, chromosomes and genomes Abcam meeting; Feb 9-11; Singapore

Chromatin Dynamics & Higher Order Organization - Keystone series; Feb 25-Mar 2; Idaho

Chromatin, Replication & Chromosomal Stability Abcam meeting; Jun 15-16; Copenhagen, Denmark

Chromatin Basics

The Nucleosome Core Particle


From: Richmond lab, Zurich 

The basic repeating unit of chromatin is the nucleosome core particle (NCP): 146bp of DNA wrapped around a core histone octamer of two H2A-H2B dimers and a (H3-H4)2 tetramer (Luger, 2003).


Introducing variation to NCPs

Variation can be introduced by covalently modifying the histones (usually but not exclusively on their protruding N-terminal tails) by a variety of enzymatic activities (including acetylation, methylation, phosphorylation and ubiquitination) (Cosgrove and Wolberger, 2005; Jenuwein and Allis, 2001; Strahl and Allis, 2000). Variant histones can also be deposited at specific sites to replace the major histones assembled during DNA replication (Malik and Henikoff, 2003). Finally, nucleosomes can be remodeled by a superfamily of ATPases (Johnson et al, 2005).


A Histone Code 

(In Progress - 10/24/06)