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Amino Acids


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   Amino acid metabolism

          

Essential Amino Acids     

PriVaTe TIM HALL

Phe, Valine, Threonine, Tryptophan, Isoleucine, Met, His, Arg, Leucine,Lys.

Arg and His are considered semiessential. 

 

Nitric oxide: amino acid precursor

When the dentist works on your teeth, you say, "AAArg! (Arginine)" before he administers Nitric Oxide (NO) to take the pain away.

· Other players necessary for NO synthesis: NO synthase, Ca++, NADPH.

 

Catabolism steps of branched chain amino acids

"Truck hit the Ox to Death":

Transamination

Oxidative decarboxylation

Dehydrogenation

 

 Branched-chain amino acids utilised by skeletal muscles in Fasting state

"Muscles VIL (will)fast":

Valine

Isoleucine

Leucine

 

Niacin deficiency: signs and symptoms

The famous 4 D's:

Diarrhoea ,Dermatitis, Dementia, Death (only when left untreated)

 

Creatine phosphate: amino acid precursors

"Creativ(n)e Porn MAGazine ":   Methionine ,Arginine ,Glycine

 Creatine phosphate (CP) serves as a an immediate store of energy in muscle .

(CP----creatine kinase---->Creatine+ATP )

Also,CP may be converted to  creatinine ,spontaneously(without help from any enzyme) which is excreted in the urine .

(CP----non enzymatic---->creatinine+Pi+H2O.)

(It's clinically useful because normally the urinary excretion of creatinine is constant, unless the muscle mass is injured.An elevated  urinary creatinine is taken as an indicator of  muscular dystrophies .)

 

AcetylCoA and acetacetylCoA: amino acids forming them

"A Lighter Lease" (A LyTr LeIs):

A=AcetylCoA or Acetoacetyl CoA

Ly=Lysine

Tr=Tryptophan

Le=Leucine 

Is=soleucine

          

Phenylketonuria: which enzyme is deficient

PHenylketonuria is caused by a deficiency of:  Phenylalanine Hydroxylase

 

 

 

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