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Cannabis & Cancer - The Science

THC / Cannabis as cancer cure studies:

Study Indicates THC May Eradicate Brain Tumors
http://norml.org/index.cfm?Group_ID=4101

Seth Group: Nontoxic Dose of Delta9-THC Kills Human Brain Tumor Cells
http://www.sethgroup.org/featured_experiment.html

Antineoplastic activity of cannabinoids
http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/default.html

Cannabinoids in pancreatic cancer: Correlation with survival and pain
http://www3.interscience.wiley.com/journal/116331134/abstract?CRETRY=1&SRETRY=0

Dr. Robert J. Melamede Ph.D. Chairman of the Biology Department of the University of Colorado: Conducting Scientific research on Cannabinoids
http://www.uccs.edu/~rmelamed/Homepage/endocannabinoids_and_medica.html
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/cancer/

Cannabinoids protect against sunburn and skin cancer because of the CB1 receptors in our skin.
http://www.thc-ministry.net/cannabisinfo.htm

Unlocking a Cure for Cancer – With Pot
http://www.lewrockwell.com/orig5/armentano-p1.html

THC to cure skin cancer?
Well, not just skin cancer. It has been documented, even videotaped (www.sethgroup.org) that THC from the cannabis plant attacks cancerous and mutated cells while leaving healthy cells unharmed
http://www.whfhhc.com/Skin-Cancer/145529.htm

One fascinating aspect of Dr. Manuel Guzman’s work is that, as the tumors being treated are in brain (nerve) tissue, the neuroprotective properties of THC become extremely important. Whereas most cancer treatments cause damage to surrounding tissue (especially crucial in the brain), THC treatments actually protect adjacent non-cancerous nerve tissue.

Anti-Cancer Properties of THC - Research in Print:
[1] Parolaro and Massi. 2008. Cannabinoids as a potential new drug therapy for the treatment of gliomas. Expert Reviews of Neurotherapeutics 8: 37-49
[2] Guzman et al. 2006. A pilot clinical study of delta-9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British Journal of Cancer.
[3] Galanti et al. 2007. Delta9-Tetrahydrocannabinol inhibits cell cycle progression in human glioblastoma multiforme cells. Acta Oncologica 12: 1-9.
[4] Calatozzolo et al. 2007. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological Sciences 28: 304-310.
[5] Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neurooncology. 2005
http://www.ncbi.nlm.nih.gov/pubmed/16078104?dopt=Citation
[6] Cannabinoids and cancer. Mini-Reviews in Medicinal Chemistry. 2005
http://www.ingentaconnect.com/content/ben/mrmc/2005/00000005/00000010/art00006
[7] The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells. Gut. 2005 http://gut.bmj.com/cgi/content/abstract/54/12/1741
[8] Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Research. 2005 http://cancerres.aacrjournals.org/cgi/content/abstract/65/5/1635
[9] Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Journal of Pharmacology And Experimental Therapeutics. 2004
http://jpet.aspetjournals.org/cgi/content/abstract/jpet.103.061002v1
[10] Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Research. 2004 http://cancerres.aacrjournals.org/cgi/content/full/64/16/5617
[11] Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro. BMJ Medicine. 2004
http://www.biomedcentral.com/1741-7015/2/34/abstract
[12] Cannabinoids: potential anticancer agents. Nature Reviews Cancer. 2003
http://americanmarijuana.org/Guzman-Cancer.pdf
[13] Inhibition of tumor angiogenesis by cannabinoids. The FASEB Journal. 2003
http://www.fasebj.org/cgi/content/full/17/3/529
[14] Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Journal of Clinical Investigation. 2003
http://www.jci.org/articles/view/16116/version/1
[15] Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nature Medicine. 2000
http://www.annieappleseedproject.org/anacofcanrat.html
[16] Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Letters. 1998 http://www.febsletters.org/article/PIIS0014579398010850/abstract
[17] The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proceedings of the National Academy of Sciences of the USA. 1998
[18] Toxicology and Carcinogenesis Studies of 1 trans-delta-9-tetrahydrocannabinol in F344N/N Rats and BC63F1 Mice. National Institutes of Health National Toxicology Program, NIH Publication No. 97-3362. 1996.
[19] Antineoplastic activity of cannabinoids. Journal of the National Cancer Institute. 1975 http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/default.html

Recent Research on Medical Marijuana
http://norml.org/index.cfm?Group_ID=7002

Delta9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
http://mcr.aacrjournals.org/cgi/content/abstract/4/8/549

Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
http://www.nature.com/nm/journal/v6/n3/fig_tab/nm0300_313_F1.html


See also ASA Forum Cannabis and Cancer

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