Cannabis & Cancer - The Science

THC / Cannabis as cancer cure studies:

Study Indicates THC May Eradicate Brain Tumors

Seth Group: Nontoxic Dose of Delta9-THC Kills Human Brain Tumor Cells

Antineoplastic activity of cannabinoids

Cannabinoids in pancreatic cancer: Correlation with survival and pain

Dr. Robert J. Melamede Ph.D. Chairman of the Biology Department of the University of Colorado: Conducting Scientific research on Cannabinoids

Cannabinoids protect against sunburn and skin cancer because of the CB1 receptors in our skin.

Unlocking a Cure for Cancer – With Pot

THC to cure skin cancer?
Well, not just skin cancer. It has been documented, even videotaped ( that THC from the cannabis plant attacks cancerous and mutated cells while leaving healthy cells unharmed

One fascinating aspect of Dr. Manuel Guzman’s work is that, as the tumors being treated are in brain (nerve) tissue, the neuroprotective properties of THC become extremely important. Whereas most cancer treatments cause damage to surrounding tissue (especially crucial in the brain), THC treatments actually protect adjacent non-cancerous nerve tissue.

Anti-Cancer Properties of THC - Research in Print:
[1] Parolaro and Massi. 2008. Cannabinoids as a potential new drug therapy for the treatment of gliomas. Expert Reviews of Neurotherapeutics 8: 37-49
[2] Guzman et al. 2006. A pilot clinical study of delta-9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British Journal of Cancer.
[3] Galanti et al. 2007. Delta9-Tetrahydrocannabinol inhibits cell cycle progression in human glioblastoma multiforme cells. Acta Oncologica 12: 1-9.
[4] Calatozzolo et al. 2007. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological Sciences 28: 304-310.
[5] Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neurooncology. 2005
[6] Cannabinoids and cancer. Mini-Reviews in Medicinal Chemistry. 2005
[7] The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells. Gut. 2005
[8] Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Research. 2005
[9] Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Journal of Pharmacology And Experimental Therapeutics. 2004
[10] Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Research. 2004
[11] Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro. BMJ Medicine. 2004
[12] Cannabinoids: potential anticancer agents. Nature Reviews Cancer. 2003
[13] Inhibition of tumor angiogenesis by cannabinoids. The FASEB Journal. 2003
[14] Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Journal of Clinical Investigation. 2003
[15] Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nature Medicine. 2000
[16] Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Letters. 1998
[17] The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proceedings of the National Academy of Sciences of the USA. 1998
[18] Toxicology and Carcinogenesis Studies of 1 trans-delta-9-tetrahydrocannabinol in F344N/N Rats and BC63F1 Mice. National Institutes of Health National Toxicology Program, NIH Publication No. 97-3362. 1996.
[19] Antineoplastic activity of cannabinoids. Journal of the National Cancer Institute. 1975

Recent Research on Medical Marijuana

Delta9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria

Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

See also ASA Forum Cannabis and Cancer