Treatment‎ > ‎

Most Potent Substances Against Lyme

Put The Lyme in the Coconut!

J Appl Microbiol. 2015 Oct 12. doi: 10.1111/jam.12970. [Epub ahead of print]

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against 

Borrelia burgdorferi and Borrelia garinii.

Abstract


AIMS: 

Little is known about the effects of phytochemicals against Borrelia sp. 
causing Lyme disease. 
Current therapeutic approach to this disease is limited to antibiotics. 
This study examined the anti-borreliaea efficacy of several plant-derived 
compounds and micronutrients.

METHODS AND RESULTS: 

We tested the efficacy of 15 phytochemicals
and micronutrients against three morphological forms of Borrelia burgdoferi 
and Borrelia garinii: spirochetes, latent rounded forms and biofilm. 
The results showed that the most potent substances against the 
spirochete and rounded forms of Borrelia burgdorferi and
Borrelia garinii were cis-2-decenoic acid, baicalein, monolaurin, and kelp (iodine); 
whereas, only baicalein and monolaurin revealed significant activity against the biofilm. 
Moreover, cis-2-decenoic acid, baicalein, and monolaurin did not cause statistically
significant cytotoxicity to human HepG2 cells up to 125 μg ml-1 , and kelp up to 20 μg ml-1 .

CONCLUSIONS: 

The most effective antimicrobial compounds against all 
morphological forms of the two tested Borrelia sp. were baicalein and 
monolaurin. This might indicate that the presence of fatty acid and 
phenyl groups is important for comprehensive antibacterial activity.

SIGNIFICANCE AND IMPACT OF THE STUDY: 

This study reveals the potential of 
phytochemicals as an important tool in the fight against the species of 
Borrelia causing Lyme disease. This article is protected by copyright. All rights reserved.
Link Here


Additional Info




Additional Monolaurin Info Below

"Research dating back 30 years first identified that the 12 carbon fatty acid2 of monolaurin was highly effective at combating gram positive bacteria and yeasts (like Candida albicans). The Candida killing ability of monolaurin3 has been established. The most research has been done on gram positive bacteria, as the compound can be used to reduce infections on poultry and help clean equipment involved in the production of food. And monolaurin is effective against many viruses. The nutrient has been in widespread use as an immune support dietary supplement for several decades."  Link Here  http://www.wellnessresources.com/health/articles/monolaurin_a_natural_immune_boosting_powerhouse/


###



J Drugs Dermatol. 2007 Oct;6(10):991-8.

Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from skin infections: an in vitro study.

Abstract

OBJECTIVE: 

A cross-sectional laboratory study to determine the in vitro sensitivity and resistance of organisms in culture isolates from skin infections and mechanisms of action of monolaurin, a coconut lauric acid derivative, compared with 6 common antibiotics: penicillin, oxacillin, fusidic acid, mupirocin, erythromycin, and vancomycin.

METHODS: 

Skin culture samples were taken from newborn to 18-year-old pediatric patients with primary and secondarily infected dermatoses. Samples were collected and identified following standard guidelines, then sent to the laboratory for sensitivity testing against the 6 selected antibiotics and monolaurin.

RESULTS: 

Sensitivity rates of Gram-positive Staphylococcus aureus, Streptococcus spp., and coagulase-negative Staphylococcus, Gram-negative E. vulneris, Enterobacter spp., and Enterococcus spp. to 20 mg/ml monolaurin was 100% and of Klebsiella rhinoscleromatis was 92.31%. Escherichia coli had progressively less dense colony growths at increasing monolaurin concentrations, and at 20 mg/ml was less dense than the control. Staphylococcus aureus, coagulase-negative Staphylococcus, and Streptococcus spp. did not exhibit any resistance to monolaurin and had statistically significant (P <.05) differences in resistance rates to these antibiotics.

CONCLUSIONS: 

Monolaurin has statistically significant in vitro broad-spectrum sensitivity against Gram-positive and Gram-negative bacterial isolates from superficial skin infections. Most of the bacteria did not exhibit resistance to it. Monolaurin needs further pharmacokinetic studies to better understand its novel mechanisms of action, toxicity, drug interactions, and proper dosing in order to proceed to in vivo clinical studies.

PMID:
 
17966176
 
[PubMed - indexed for MEDLINE]