Luca Cocchi

I'm currently head of the Clinical Brain Networks team at the QIMR Berghofer Medical Research Institute (http://www.qimrberghofer.edu.au/lab/clinical-brain-networks-group/). I'm broadly interested in studying the anatomical structure and functional brain dynamics supporting the optimal integration of information, in health and diseases.

I am pleased to consider applications from prospective PhD students.

Contact:
Dr Luca Cocchi
QIMR Berghofer Medical Research Institute
300 Herston Rd
4006, Brisbane, Queensland, Australia

                *** Currently recruiting for an OCD clinical trial: https://trialfacts.com/help-fight-ocd-by-participating-in-a-research-study/ ***

A) Peer-Reviewed Publications

Electronic versions are provided as a professional courtesy to ensure timely dissemination of academic work for individual, noncommercial purposes. Copyright and all rights therein resides with the respective copyright holders, as stated within each paper. These files may not be reposted without permission.

    2018

Cocchi L., Zalesky, A. In press. Personalized transcranial magnetic stimulation in psychiatry. Biological Psychiatry CNNI.[PDF] 

Lin, H.S.*, Cocchi L.*, Zalesky A., Lv J., Perry A., Isaac Tseng W.Y., Kundu, P., Breakspear M., Gau S.S.G. In press. Brain-behavior patterns define a dimension biotype in medication-naïve adults with attention-deficit hyperactivity disorder. Psychological Medicine. [PDF] * Equal contribution

Cocchi L., Zalesky A., Nott Z., Whybird G., Fitzgerald P.B., Breakspear M. In press. Transcranial magnetic stimulation in obsessive-compulsive disorder: A focus on network mechanisms and state dependence. NeuroImage: Clinical.[PDF]

2017

Cocchi L., Gollo, L.L., Zalesky A., Breakspear M. 2017. Criticality in the brain: A synthesis of neurobiology, models and cognition. Progress in Neurobiology. S0301-0082(16)30163-0.[PDF]

Hearne L.J., Cocchi L., Zalesky A., Mattingley J.B. 2017. Reconfiguration of brain network architectures between resting state and complexity dependent cognitive reasoning. Journal of neuroscience. Aug 30;37(35):8399-8411.[PDF]

Sale M.V., Reid L.B., Cocchi L., Pagnozzi A.M., Rose S.E., Mattingley J.B. 2017. Structural and functional brain changes following four weeks of unimanual motor training: evidence from behaviour, neural stimulation, cortical thickness and functional MRI. Human Brain Mapping. Sep;38(9):4773-4787.[PDF]   

Cocchi L., Yang Z., Zalesky A., Stelzer J., Hearne L., Gollo L.L., Mattingley J.B. 2017. Neural decoding of visual stimuli varies with fluctuations in global network efficiency. Human Brain Mapping. 38(6):3069-3080.[PDF]

Gollo, L.L., Roberts, J., Cocchi L. 2017. Mapping how local perturbations influence systems-level brain dynamics. NeuroImage.2017 Oct 15;160:97-112.[PDF]

    2016

Cocchi L., Sale MV, Gollo L.L., Bell P., Nguyen V., Zalesky A., Breakspear M., Mattingley J.B. 2016. A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields. eLIFE. 15252.001. [PDF]

Hearne L., Mattingley J.B., Cocchi L. 2016. Functional brain networks related to individual differences in human intelligence at rest. Scientific Reports.[PDF]

Klauser P., Baker S., Cropley V.L., Bousman C.A., Fornito A., Cocchi L., Fullerton J.M., Schall U., Henskens F., Michie P.T., Loughland C., Catts S.V., Mowry B.J., Weickert T., Weickert C.S., Carr V., Lenroot R., Pantelis C., Zalesky A. 2016. Axonal disruptions in schizophrenia converge on brain network hubs. Schizophrenia Bulletin. Aug 17. pii: sbw100 [Epub ahead of print].[PDF]

Zalesky A., Fornito A., Cocchi L., Gollo L.L., van den Heuvel M., Breakspear M. 2016. Connectome sensitivity or specificity: which is more important? Neuroimage. Jun 27. pii: S1053-8119(16)30284-1.[PDF]

2015

Sale M.V., Zalesky, A., Mattingley, J.B., Cocchi, L. 2015. Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation. Neuroscience & Biobehavioral Reviews. 57: 187-198.[PDF]   

Zalesky A., Pantelis C., Croppley V., Fornito A., Cocchi L., McAdams H., Clasen L., Greenstein D., Rapaport J.L., Gogtay N. 2015. Delayed development of brain connectivity in children with schizophrenia and their nonpsychotic siblings. JAMA Psychiatry.72(9):900-8.[PDF]

Cocchi L., Sale M., Lord A., Zalesky A., Breakspear M., Mattingley J.B. 2015. Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics. Journal of Neurophysiology. 113: 3375-3385.[PDF]

Hearne L.*, Cocchi L.*, Zalesky A., Mattingley J.B. 2015. Interactions between default mode and control networks as a function of increasing cognitive reasoning complexity. Human Brain Mapping. 36:2719-2731.[PDF]. *Equal contribution

2014

Cocchi L.*, Harding I.H.*, Lord A., Pantelis C., Yucel M., Zalesky A. 2014. Disruption of Structure-Function Coupling in the Schizophrenia Connectome. NeuroImage: Clinical. 4:779-787.[PDF]. *Equal contribution

Zalesky A., Fornito A., Cocchi L., Gollo L.L., Breakspear, M. 2014. Time-resolved resting-state brain networks. Proc Natl Acad Sci U S A. 111(28):10341-6.[PDF]

Cocchi L., Halford G.S., Zalesky A., Harding I.H., Ramm B., Cutmore T., Shum D., Mattingley J.B. 2014. Complexity in relational processing predicts changes in functional brain network dynamics. Cerebral Cortex. 24(9):2283-96.[PDF] 

2013

Cocchi L., Zalesky A., Fornito A., Mattingley J.B. 2013. Dynamic cooperation and competition between brain systems during cognitive control. Trends in Cognitive Sciences. 17 (10): 483-544.[PDF]

Hong S.B., Zalesky A., Cocchi L., Fornito A, Choi E.J., Kim H.H., Suh J.E., Kim C. D., Kim J. V., Yi S.H. 2013. Decreased Functional Brain Connectivity in Adolescents with Internet Addiction. Plos One. 8(2), e57831.[PDF]

2012

Cocchi L., Bramati I. E., Zalesky A., Furukawa E., Fontenelle L., Moll J., Tripp, G., Mattos P. 2012. Altered functional brain connectivity in a non-clinical sample of young adults with Attention-Deficit/Hyperactivity Disorder. Journal of Neuroscience. 32(49):17753-61. [PDF] 

Fontenelle L.F, Cocchi L., Harrison B.J., Shavitt R.F., Rosário M.C., Ferrão Y.A., De Mathis M.A., Cordioli A.V., Yucel M., Mari J.J., Miguel E.C., Torres A.R. 2012. Towards a post-traumatic subtype of obsessive-compulsive disorder. Journal of Anxiety Disorders. 26 (2): 377–383 [PDF]

Whitford T.J., Wood S.J., Yung A., Cocchi L., Yolken R., Kubicki N., Shenton M., McGorry P., Velakoulis D., Pantelis C., Amminger P. 2012. Herpes simplex infection and brain structure in people at ultra-high risk of schizophrenia. 135 (1-3): 175-180. Schizophrenia Research. [PDF]

Zalesky A., Cocchi L., Fornito A., Murray M.M., Bullmore, E.T. Connectivity differences in brain networks. 2012. NeuroImage. 60 (2):1055-62.[PDF] 

Cocchi L., Zalesky A., Fontenelle L. F., How can connectomics advance our knowledge of psychiatric disorders? 2012. Revista Brasileira de Psiquiatria. 34 (2): 131-134.[PDF]

Bora E., Yücel M., Fornito A., Pantelis C., Harrison B. J., Cocchi L., Pell G., Lubman D. 2012. White matter microstructure in opiate addiction. 2012. Addiction Biology. 17 (1):141-8.[PDF]

Cocchi L., Harrison B. J., Jesus P., Harding H. I., Fornito A., Pantelis C., Yucel M. Functional alterations of brain networks related to cognitive control in Obsessive-Compulsive Disorder. 2012. Human Brain Mapping. 33(5):1089–1106.[PDF]

Fontenelle L. F., Cocchi, L., Harrison B.J., Miguel E., Torres A. The role of stressful and traumatic life events in obsessive-compulsive disorder. 2012. Neuropsychiatry. 1 (1):61-69.[PDF]

2011

Zalesky A., Fornito A., Seal M. L., Cocchi L., Westinc C.L., Bullmore E. T., Egan G.F., Pantelis C. Disrupted Axonal Fiber Connectivity in Schizophrenia. 2011. Biological Psychiatry. 69 (1), 80-89.[PDF]

Bora, E,. Harrison, B.J., Fornito, A., Cocchi, L., Pujol, J., Fontenelle, L., Velakoulis, D., Pantelis C., Yücel M. 2011. White matter microstructure in Obsessive-Compulsive Disorder. Journal of Psychiatry and Neuroscience. 36 (1),42-46.[PDF]

Cocchi L., Toppel U., De Lucia M., Martuzzi R., Wood S.J, Carter O., Murray MM. Working memory improves early stages of independent visual processing. 2011. Neuropsychologia. 49 (1), 92-102.[PDF]

Cocchi L., Zalesky A., Toppel U., De Lucia M., Murray M.M., Carter O. Dynamic Changes in Brain Functional Connectivity during Concurrent Dual-Task Performance. 2011. PloS ONE. 6 (11):e28301.[PDF]

2010

Debbané M., Murray R.,  Damsa C., Cocchi L., Glaser B., Eliez S. Visual processing and social cognition in children and adolescents with autistic traits. 2010. Neuropsychiatrie de l'enfant et de l'adolescent. 58, 463-468.[PDF]

De-Lucia M., Cocchi L., Martuzzi R., Mueli R., Clarke S., Murray M. Perceptual and semantic contributions to repetition priming of environmental sounds. 2010. Cerebral  Cortex. 20(7), 1676-1684.[PDF]

Zalesky A., Fornito A., Harding I., Cocchi L., Yucel M., Pantelis C., Bullmore E. T. Whole-Brain structural networks: Does the choice of nodes matter? 2010. NeuroImage. 50 (3), 970-983.[PDF]

Wood S., Cocchi L., Proffitt T.M., Jackson G.D., Pantelis C., McGorry P., Berger GE. Neuroprotective effects of Ethyl-Eicosapentaenoic Acid in first episode schizophrenia: a longitudinal T2 relaxometry pilot study. 2010. Psychiatry Research Neuroimaging. 30 (2),180-2.[PDF]

2009

Cocchi L., Debbané M, Vianin P., Bircher R., Roulin S., Conus P., Sarrasin-Bruchez P., Bovet P., Volken H., Wood S.J., Schenk F. 2009. Encoding dysfunctions in dynamic – static paradigm for visuospatial working memory in first episode psychosis patients: A 2 years follow-up study. Early Intervention in Psychiatry. 3 (1), 44-51.[PDF]

Cocchi L., Bosisio F., Berchtold A., Orita A., Debbané M.; Wood J.S. and Schenk F. 2009. Visuospatial encoding deficits in schizophrenia revealed by eye movement analysis during a working memory task. Acta Neuropsychiatrica. 21 (2), 75-83.[PDF]

Cocchi L., Bosisio F., Wood S.J., Berchtold F., Conus P., Orita A., Debanné M., Schenk F., Visuospatial working memory deficits and visual pursuit impairments are not directly related in schizophrenia. 2009. Australian and New Zealand Journal of Psychiatry. 43(8), 766-774.[PDF]

Cocchi L., Walterfang M., Testa R., Seal M., Wood S.J., Suckling J., Takahashi T., Proffitt T.M, Brewer J.W., Adamson C., Soulsby B., Velakoulis D., McGorry P., Pantelis C. Grey and white matter abnormalities are associated with impaired spatial working memory ability in first episode schizophrenia. 2009. Schizophrenia Research. 115 (2-3), 163-172.[PDF]

    2008

Sautter C., Cocchi L., Schenk F. 2008. Dynamic visual information plays a critical role during spatial learning in the Morris water maze but not on solid ground. Behavioural Brain Research. 194 (2), 242-245.[PDF]
    
     2007

Cocchi L., Schenk F., Volken H., Bovet P., Parnas J., Vianin P. 2007. Visuo-spatial processing in a dynamic and a static working memory paradigm in schizophrenia; Psychiatry Research, 152:129-142.[PDF]

Schenk, F. & Cocchi, L. 2007. Biology’s view of mental activity: oversimplification or new prospect? Psychiatrie Neurosciences et Sciences Humaines, 5(Supp 1).[PDF]

B) Books

Preissmann D., Cocchi L., Cabungcal J., and Schenk F. 2008. Animal models of schizophrenia: in search of a common key neurological syndrome in rats and humans. In: Endophenotypes of psychiatric and neurodegenerative disorders in animal models. G.S. Pandalai (Eds). Kerala, India: Research Signpost.

C) Algorithms
: Network-Based Statistic (NBS)

http://www.nitrc.org/projects/nbs

Matlab toolbox for testing hypotheses about the human connectome. NBS has been widely used to identify connections and networks comprising the connectome that are associated with an experimental effect or a between-group difference. User provides a series of connectivity matrices from different cohorts, or from the same subject during different experimental conditions. Connectivity matrices are inferred from neuroimaging data using other packages that, for example, count the number of tractography streamlines that interconnect each pair of regions (diffusion-MRI), or measure the extent of inter-regional correlation in BOLD response (fMRI). User specifies hypothesis to be tested at every connection with the general linear model. Features include: graphical user interface; NBSview, a basic network viewer modeled on SPMresults; exchange blocks for repeated measures; options to measure network size with intensity or extent; false discovery rate (FDR) option. Developed by Zalesky et al.

D) Support for research
01/2018 - 12/2021. NHMRC project grant.(CIA).
01/2018 - 12/2020. NHMRC project grant.(CIC).
01/2018 - 12/2020. ARC: DP180101641.(PI)
12/2017.  UQ Major Equipment and Infrastructure (MEI) and 2017 NHMRC Equipment Grant (CIB)
02/2016 - 02/2019 NHMRC project grant (CIA)
12/2012 - 12/2013 UQ Early Career Grant Scheme
02/2010 – 02/2011 Swiss Foundation for Grants in Biology and Medicine: Advanced researcher
02/2009 – 02/2010 Swiss National Science Foundation; young scientist award
02/2008 – 02/2009 Swiss National Science Foundation; young scientist award
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