Our laboratory is within the School of Public Health and Health Sciences, University of Massachusetts, Amherst. We are also a part of several cross-campus programs: Model to Medicine Center, Center for Bioactive Delivery and Molecular and Cellular Biology Graduate Program at UMass Amherst. The laboratory holds a close relationship with the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
Diet and lifestyle are modifiable factors which play a critical role in public health. Our laboratory investigates how those factors and their metabolically-related gene variants interact to mediate the development of chronic diseases. For a long period, our research has been focusing on 1) nutritional epigenetics and 2) obesity-driven inflammation in the regulation of Wnt pathway and the prevention of cancer. We utilize cell culture, animal models and human biospecimens, biochemical and molecular techniques, as well as nutritional informatics and functional genomic approaches to understand the etiology of human chronic diseases. The ultimate goal of my laboratory is to integrate our biological findings with dietary and lifestyle strategies to diminish the burden of chronic diseases in our society.