Peer-Reviewed Original Research

1.    Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K. (2019) Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis.  Cell Metabolism 30, 784-799.  PMID: 31474566.  PMCID: PMC7054893.

2.    Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, et al. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell 49, 10-29.  PMID: 30930166.  PMCID: PMC6616346

3.    Hu P, Liu J, Zhao J, Wilkins BJ, Lupino K, Wu H, Pei L (2018). Single-nucleus transcriptomic survey of cell diversity and functional remodeling in the postnatal developing hearts. 
Genes & development 32, 1344-1357. PMID: 30254108. PMCID: PMC6169839
 
4.    Li J, Liu J, Lupino K, Liu X, Zhang L, Pei L (2018) GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6. Molecular and Cellular Biology. PMID: 30104250.
PMCID: PMC6189459.

5.    Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y, Allred AL, McDonald C, Susztak K, Barish GD, Pei L (2018) Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease. Proceedings of National Academy of Sciences 115, E4910-E4919. PMID: 29735694.

6.    Wang T, Liu J, McDonald, C, Lupino K, Zhai X, Wilkins BJ, Hakonarson H, Pei L (2017). GDF15 is a heart-derived hormone that regulates body growth. EMBO Molecular Medicine 9, 1150-1164. PMID: 28572090. PMCID: PMC5538424.

7.    Emmett MJ, Lim H, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won K, Seale P, Gerhart-Hines Z, Lazar MA (2017). Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature 546, 544-548. PMID: 28614293. PMCID: 5826652.

8.    Pei L*, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM* (2015). Dependence of hippocampal function on ERRγ regulated mitochondrial metabolism. Cell Metabolism 21, 628-636 (*co-corresponding author, featured in cover). PMID: 25863252. PMCID: PMC4393848.

9.    Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, Pei L (2015). ERRalpha and ERRgamma are essential coordinators of cardiac metabolism and function. Molecular and Cellular Biology 35, 1281-1298. PMID: 25624346. PMCID: PMC4355525.

10.    Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P (2013). Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization inmice. Journal of Lipid Research 54, 806-815. PMID: 23288947. PMCID: PMC3617954.

11.    Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li H, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM (2011). Thyroid hormone receptor repression is linked to type I pneumocyte associated respiratory distress syndrome. Nature Medicine 17, 1466-1472. PMID: 22001906. PMCID: PMC3210920.

12. Berry R, Harewood L, Pei L, Fisher M, Brownstein D, Ross A, Alaynick WA, Moss J, Hastie ND, Hohenstein P, Davies JA, Evans RM, FitzPatrick DR (2011). Esrrg functions in early branch generation of the ureteric bud and isessential for normal development of the renal papilla. Human Molecular Genetics 20, 917-926. PMID: 21138943. PMCID: PMC3033182

13. Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN (2010). ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Molecular Endocrinology 24, 299-309. PMID: 19965931. PMCID: PMC2817599.

14. Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P (2009). Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes 58, 2788-2796. PMID: 19741162. PMCID: PMC2780886.

15. Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM (2008). SMRT repression of nuclear receptors controls theadipogenic set point and metabolic homeostasis. Proceedings of National Academy of Sciences 105, 20021-20026. PMID: 19066220. PMCID: PMC2598729.

16. Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF (2007). Nur77 coordinatelyregulates expression of genes linked to glucose metabolism in skeletal muscle. Molecular Endocrinology 21, 2152-2163. PMID: 17550977. PMCID: PMC2602962.

17. Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P (2007). The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARgamma Expression. Cell Metabolism 5, 357-370. PMID: 17488638.

18. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P (2006). NR4A orphan nuclear receptors aretranscriptional regulators of hepatic glucose metabolism. Nature Medicine 12, 1048-1055. PMID: 16906154.

19. Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng, G (2006). A rolefor IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. Journal of Experimental Medicine 203, 2589-2602. PMID: 17074929. PMCID: PMC2118146.

20. Baldan A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA (2006). Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arteriosclerosis, Thrombosis, and Vascular Biology 26, 2301-2307. PMID: 16888235.

21. Pei L, Castrillo A, Tontonoz P (2006). Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Molecular Endocrinology 20, 786-794. PMID: 16339277.

22. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P (2005). Induction of NR4A orphan nuclear receptor expressionin macrophages in response to inflammatory stimuli. Journal of Biological Chemistry 280, 29256-29262. PMID: 15964844.

23. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM (2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 120, 261-273. PMID: 15680331.

24. Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'Connell RM, Cheng G, Saez E, Miller JF, Tontonoz P (2004). LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 119, 299-309. PMID: 15479645.

25. Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, and Tontonoz, P. (2004). Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. Journal of Biological Chemistry 279, 9905-9911. PMID: 14699103.

26. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P (2002). Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proceedings of National Academy of Sciences 99, 7604-7609. PMID: 12032330. PMCID: PMC124297.

27. Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P (2001). Autoregulation of the human liver X receptor alpha promoter. Molecular and Cellular Biology 21, 7558-7568. PMID: 11604492. PMCID: PMC99927.

 
Invited Reviews
 
28. Pei L, Wallace DC (2017). Mitochondrial Etiology ofNeuropsychiatric Disorders.  Biological Psychiatry. PMID: 29290371. PMCID: PMC5891364.

29. Pei L, Evans RM (2009). Retrofitting fat metabolism. Cell Metabolism 9, 483-484. PMID: 19490901.

30. Sonoda J, Pei L, Evans RM (2008). Nuclear receptors: Decoding metabolic disease. FEBS Letter 582, 2-9. PMID: 18023286. PMCID: PMC2254310.

31. Pei L, Tontonoz P (2004). Fat's loss is bone's gain. Journal of Clinical Investigation 113, 805-806. PMID: 15067310. PMCID: PMC362126.